Plasma kinetics of vitamin A in humans after a single oral dose of [8,9,19-13C]retinyl palmitate

Journal of Lipid Research

Volumn 37, Issue 9, 1996, Pages 1875-1885

  Reinersdorff, D V ^a   Bush, E ^b   Liberato, D J ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

mass spectrometric method; retinol; retinyl esters; stable isotopes; vitamin A metabolism

Indexed keywords

CARBON 13; ISOTRETINOIN; RETINOIC ACID; RETINOL; RETINOL BINDING PROTEIN; RETINOL ESTER; RETINOL OLEATE; RETINOL PALMITATE; RETINOL STEARATE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; CARBON ISOTOPES; ESTERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; TIME FACTORS; VITAMIN A;

EID: 0029837377     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Sporn, M. B., A. B. Roberts, and D. S. Goodman, editors. 1994. The Retinoids. Raven Press, New York. 211-228, 351-544.
2. Olson, J. A. 1994. Vitamin A, retinoids, and carotenoids. In Modern Nutrition in Health and Disease. Vol. 1. 8th edition. M. E. Shils, J. A. Olson, and M. Shike, editors. Lea & Febiger, Philadelphia. 287-307.
3. Blomhoff, R., M. H. Green, J. B. Green, T. Berg, and K. R. Norum. 1991. Vitamin A metabolism: new perspectives on absorption, transport, and storage. Physiol. Rev. 71: 951-990.
4. Mangelsdorf, D. J. 1994. Vitamin A receptors. Nutr. Rev. 52: S32-S44.
5. De Luca, L. M. 1991. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J. 5: 2924-2933.
6. Ong, D. E. 1994. Cellular transport and metabolism of vitamin A: roles of the cellular retinoid-binding proteins. Nutr. Rev. 52: S24-S31.
7. Napoli, J. L. 1993. Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis. J. Nutr. 123: 362-366.
8. Green, M. H., and J. B. Green. 1994. Dynamics and control of plasma retinol. In Vitamin A in Health and Disease. R. Blomhoff, editor. Marcel Dekker, Inc. New York, NY. 119-133.
9. Green, M. H., L. Uhl, and J. B. Green. 1985. A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores. J. Lipid Res. 26: 806-818.
10. Green, M. H., J. B. Green, and K. C. Lewis. 1987. Variation in retinol utilization rate with vitamin A status in the rat. J. Nutr. 117: 694-703.
11. Green, M. H., and J. B. Green. 1987. Multicompartmental analysis of whole body retinol dynamics in vitamin A-sufficient rats. Fed. Proc. 46: 1011 (Abstract).
12. Green, M. H., J. B. Green, T. Berg, K. R. Norum, and R. Blomhoff. 1988. Changes in hepatic parenchymal and nonparenchymal cell vitamin A content during vitamin A depletion in the rat. J. Nutr. 118: 1331-1335.
13. Lewis, K. C., M. H. Green, J. B. Green, and L. A. Zech. 1990. Retinol metabolism in rats with low vitamin A status: a compartmental model. J. Lipid Res. 31: 1535-1548.
14. Green, M. H., J. B. Green, T. Berg, K. R. Norum, and R. Blomhoff. 1993. Vitamin A metabolism in rat liver: a kinetic model. Am. J. Physiol. 264: G509-G521.
15. 8 metabolism in humans utilizing tandem mass spectrometry and high-performance liquid chromatography. Anal. Chem. 66: 4177-4185.
16. 4 to retinol isolated from human plasma. Anal. Chem. 65: 2024-2028.
17. Sauberlich, H. E., R. E. Hodges, D. L. Wallace, H. Kolder, J. E. Canham, J. Hood, N. Raica Jr., and L. K. Lowry. 1974. Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam. Horm. 32: 251-275.
18. Furr, H. C., O. Amédée-Manesme, A. J. Clifford, H. R. Bergen 3rd, A. D. Jones, D. P. Anderson, and J. A. Olson. 1989. Vitamin A concentrations in liver determined by isotope dilution assay with tetradeuterated vitamin A and by biopsy in generally healthy adult humans. Am. J. Clin. Nutr. 49: 713-716.
19. Green, M. H., and J. B. Green. 1990. The application of compartmental analysis to research in nutrition. Annu. Rev. Nutr. 10: 41-61.
20. 14C-labeled vitamin A alcohol and β-carotene in the rat. J. Biol. Chem. 240: 2839-2844.
21. Furr, H. C., A. B. Barua, and J. A. Olson. 1994. Analytical methods. In The Retinoids: Biology, Chemistry, and Medicine. Second edition. M. B. Sporn, A. B. Roberts, and D. S. Goodman, editors. Raven Press, New York, NY. 182-210.
22. Furr, H. C., D. A. Cooper, and J. A. Olson. 1986. Separation of retinyl esters by non-aqueous reversed-phase high-performance liquid chromatography. J. Chromatogr. 378: 45-53.
23. Furr, H. C., A. J. Clifford, and A. D. Jones. 1992. Analysis of apocarotenoids and retinoids by capillary gas chromatography-mass spectrometry. Methods Enzymol. 213: 281-290.
24. Cullum, M. E., M. H. Zile, and S. W. Veysey. 1984. Analysis of retinol and dideuterated retinol in rat plasma by gas chromatography combined mass spectrometry. Int. J. Nutr. Res. 54: 11-16.
25. Kisner, H. J., and C. W. Brown. 1983. Multiple analytical frequencies and standards for the least-squares spectrometric analysis of serum lipids. Anal Chem. 55: 1703-1707.
26. Cobelli, C., G. Tofflolo, D. M. Bier, and R. Nosadini. 1987. Models to interpret kinetic data in stable isotope tracer studies. Endocrinol. Metab. 16: E551-E564.
27. Rowland, M., and T. N. Tozer. 1989. Clinical Pharmacokinetics. Concepts and Applications. Lea & Febiger, Malvern, PA. 459, 35.
28. Eckhoff, C., M. D. Collins, and H. Nau. 1991. Human plasma all-trans-, 13-cis- and 13-cis-4-oxoretinoic acid profiles during subchronic vitamin A supplementation: comparison to retinol and retinyl ester plasma levels. J. Nutr. 121: 1016-1025.
29. Garry, P. J., W. C. Hunt, J. L. Bandrofchak, D. Vanderjagt, and J. S. Goodwin. 1987. Vitamin A and plasma retinol levels in healthy elderly men and women. Am. J. Clin. Nutr. 46: 989-994.
30. Smith, F. R., and D. S. Goodman. 1976. Vitamin A transport in human vitamin A toxicity. N. Engl. J. Med. 294: 805-808.
31. Berr, F. 1992. Characterization of chylomicron remnant clearance by retinyl palmitate label in normal humans. J. Lipid Res. 33: 915-930.
32. Berr, F., and F. Kern, Jr. 1984. Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects. J. Lipid Res. 25: 805-812.
33. Blomhoff, R., and K. Wake. 1991. Perisinoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5: 271-277.
34. Rietz, P., O. Wiss, and F. Weber. 1974. Metabolism of vitamin A and the determination of vitamin A status. Vitam. Horm. 32: 237-249.
35. Blomhoff, R., M. H. Green, and K. R. Norum. 1992. Vitamin A: physiological and biochemical processing. Annu. Rev. Nutr. 12: 37-57.
36. Goodman, D. S., R. Blomstrand, B. Werner, H. S. Huang, and T. Shiratori. 1966. The intestinal absorption and metabolism of vitamin A and beta-carotene in man. J. Clin. Invest. 45: 1615-1623.