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Volumn 24, Issue 3, 2006, Pages 115-121

Hypoglycemia in type 1 and type 2 diabetes: Physiology, pathophysiology, and management

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CARBOHYDRATE; GLUCOSE; INSULIN; MEGLITINIDE;

EID: 33748366186     PISSN: 08918929     EISSN: 08918929     Source Type: Journal    
DOI: 10.2337/diaclin.24.3.115     Document Type: Review
Times cited : (123)

References (48)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long term complication in insulin-dependent diabetes mellitus
    • The DCCT Research Group: The effect of intensive treatment of diabetes on the development and progression of long term complication in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes
    • The U.K. Prospective Diabetes Study Group: Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes. Lancet 352:837-853, 1998
    • (1998) Lancet , vol.352 , pp. 837-853
  • 3
    • 0034968632 scopus 로고    scopus 로고
    • Hypoglycemia risk reduction in type 1 diabetes
    • Cryer PE: Hypoglycemia risk reduction in type 1 diabetes. Exp Clin Endocrinol Diabetes 109:S412-S423, 2001
    • (2001) Exp Clin Endocrinol Diabetes , vol.109
    • Cryer, P.E.1
  • 4
    • 2442710176 scopus 로고    scopus 로고
    • Current concepts: Diverse causes of hypoglycemia-associated autonomic failure in diabetes
    • Cryer PE: Current concepts: Diverse causes of hypoglycemia-associated autonomic failure in diabetes. N Engl J Med 350:2272-2279, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2272-2279
    • Cryer, P.E.1
  • 8
    • 33644817974 scopus 로고    scopus 로고
    • Hypoglycemia in type 2 diabetes
    • Zammitt NN, Frier BM: Hypoglycemia in type 2 diabetes. Diabetes Care 28:2948-2961, 2005
    • (2005) Diabetes Care , vol.28 , pp. 2948-2961
    • Zammitt, N.N.1    Frier, B.M.2
  • 9
    • 0034797567 scopus 로고    scopus 로고
    • Symptoms of hypoglycemia in people with diabetes
    • McAuley V, Deary IJ, Freier BM: Symptoms of hypoglycemia in people with diabetes. Diabet Med 18:690-705, 2001
    • (2001) Diabet Med , vol.18 , pp. 690-705
    • McAuley, V.1    Deary, I.J.2    Freier, B.M.3
  • 10
    • 0024269080 scopus 로고
    • Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release
    • Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907, 1988
    • (1988) Diabetes , vol.37 , pp. 901-907
    • Amiel, S.A.1    Sherwin, R.S.2    Simonson, D.C.3    Tamborlane, W.V.4
  • 11
    • 0031006603 scopus 로고    scopus 로고
    • Hypoglycemia in the Diabetes Control and Complications Trial
    • The DCCT Research Group: Hypoglycemia in the Diabetes Control and Complications Trial. Diabetes 46:271-286, 1997
    • (1997) Diabetes , vol.46 , pp. 271-286
  • 12
    • 0027399450 scopus 로고
    • Frequency and symptoms of hypoglycaemia experienced by patients with type 2 diabetes treated with insulin
    • Hepburn DA, MacLeod KM, Pell AC, Scougal IJ, Frier BM: Frequency and symptoms of hypoglycaemia experienced by patients with type 2 diabetes treated with insulin. Diabet Med 10:231-237, 1993
    • (1993) Diabet Med , vol.10 , pp. 231-237
    • Hepburn, D.A.1    MacLeod, K.M.2    Pell, A.C.3    Scougal, I.J.4    Frier, B.M.5
  • 16
    • 0023941280 scopus 로고
    • Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics
    • Boyle PJ, Schwartz NS, Shah SD, Clutter WE, Cryer PE: Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. N Engl J Med 318:1487-1492, 1988
    • (1988) N Engl J Med , vol.318 , pp. 1487-1492
    • Boyle, P.J.1    Schwartz, N.S.2    Shah, S.D.3    Clutter, W.E.4    Cryer, P.E.5
  • 17
    • 0026035949 scopus 로고
    • Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans
    • Heller SR, Cryer PE: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes 4:223-226, 1991
    • (1991) Diabetes , vol.4 , pp. 223-226
    • Heller, S.R.1    Cryer, P.E.2
  • 18
    • 0035021085 scopus 로고    scopus 로고
    • Effects of morning hypoglycemia on neuroendocrine and metabolic responses to subsequent afternoon hypoglycemia in normal man
    • Davis SN, Tate D: Effects of morning hypoglycemia on neuroendocrine and metabolic responses to subsequent afternoon hypoglycemia in normal man. J Clin Endocrinol Metab 86:2043-2050, 2001
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2043-2050
    • Davis, S.N.1    Tate, D.2
  • 19
    • 0027465021 scopus 로고
    • Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus
    • Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. J Clin Invest 91:819-828, 1993
    • (1993) J Clin Invest , vol.91 , pp. 819-828
    • Dagogo-Jack, S.E.1    Craft, S.2    Cryer, P.E.3
  • 20
    • 0003859998 scopus 로고    scopus 로고
    • Defective glucose counterregulation in type 2 diabetes
    • Segel SA, Paramore DS, Cryer PE: Defective glucose counterregulation in type 2 diabetes (Abstract). Diabetes 49: A131, 2000
    • (2000) Diabetes , vol.49
    • Segel, S.A.1    Paramore, D.S.2    Cryer, P.E.3
  • 21
    • 0034627153 scopus 로고    scopus 로고
    • Hypoglycaemic counterregulation at normal blood glucose concentrations in patients with well controlled type 2 diabetes
    • Spyer G, Hattersley AT, MacDonald IA, Amiel S, MacLeod KM: Hypoglycaemic counterregulation at normal blood glucose concentrations in patients with well controlled type 2 diabetes. Lancet 356:1970-1974, 2000
    • (2000) Lancet , vol.356 , pp. 1970-1974
    • Spyer, G.1    Hattersley, A.T.2    MacDonald, I.A.3    Amiel, S.4    MacLeod, K.M.5
  • 22
    • 0028009378 scopus 로고
    • Altered responses to hypoglycemia of healthy elderly people
    • Meneilly GS, Cheung E, Tuokko H: Altered responses to hypoglycemia of healthy elderly people. Diabetes 43:403-410, 1994
    • (1994) Diabetes , vol.43 , pp. 403-410
    • Meneilly, G.S.1    Cheung, E.2    Tuokko, H.3
  • 23
    • 0031969717 scopus 로고    scopus 로고
    • Perceived symptoms of hypoglycaemia in elderly type 2 diabetic patients treated with insulin
    • Jaap AJ, Jones GC, McCrimmon RJ, Deary IJ, Frier BM: Perceived symptoms of hypoglycaemia in elderly type 2 diabetic patients treated with insulin. Diabet Med 15:398-401, 1998
    • (1998) Diabet Med , vol.15 , pp. 398-401
    • Jaap, A.J.1    Jones, G.C.2    McCrimmon, R.J.3    Deary, I.J.4    Frier, B.M.5
  • 24
    • 0030852089 scopus 로고    scopus 로고
    • Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas
    • Shorr RI, Ray WA, Daugherty JR, Griffin MR: Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Arch Intern Med 157:1681-1686, 1997
    • (1997) Arch Intern Med , vol.157 , pp. 1681-1686
    • Shorr, R.I.1    Ray, W.A.2    Daugherty, J.R.3    Griffin, M.R.4
  • 25
    • 0031024007 scopus 로고    scopus 로고
    • Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men
    • Matyka K, Evans M, Lomas J, Cranston I, MacDonald I, Amiel SA: Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men. Diabetes Care 20:135-141, 1997
    • (1997) Diabetes Care , vol.20 , pp. 135-141
    • Matyka, K.1    Evans, M.2    Lomas, J.3    Cranston, I.4    MacDonald, I.5    Amiel, S.A.6
  • 27
    • 0027424397 scopus 로고
    • The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus
    • Davis SN, Goldstein RE, Price L, Jacobs J, Cherringon AD: The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 77:1300-1307, 1993
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1300-1307
    • Davis, S.N.1    Goldstein, R.E.2    Price, L.3    Jacobs, J.4    Cherringon, A.D.5
  • 29
    • 0033970583 scopus 로고    scopus 로고
    • Hypoglycemic counterregulatory responses differ between men and women with type 1 diabetes
    • Davis SN, Fowler S, Costa F: Hypoglycemic counterregulatory responses differ between men and women with type 1 diabetes. Diabetes 49:65-72, 2000
    • (2000) Diabetes , vol.49 , pp. 65-72
    • Davis, S.N.1    Fowler, S.2    Costa, F.3
  • 30
  • 31
    • 33644664033 scopus 로고    scopus 로고
    • Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    • Cryer PE: Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54:3592-3598, 2005
    • (2005) Diabetes , vol.54 , pp. 3592-3598
    • Cryer, P.E.1
  • 32
    • 0020674603 scopus 로고
    • Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy
    • White NH, Skor A, Cryer PE, Levandoski L, Dier DM, Santiago JV: Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485-491, 1993
    • (1993) N Engl J Med , vol.308 , pp. 485-491
    • White, N.H.1    Skor, A.2    Cryer, P.E.3    Levandoski, L.4    Dier, D.M.5    Santiago, J.V.6
  • 33
    • 0030837024 scopus 로고    scopus 로고
    • Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans
    • Davis SN, Shavers C, Mosqueda-Garcia R, Costa F: Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans. Diabetes 46:1328-1335, 1997
    • (1997) Diabetes , vol.46 , pp. 1328-1335
    • Davis, S.N.1    Shavers, C.2    Mosqueda-Garcia, R.3    Costa, F.4
  • 34
    • 0031755625 scopus 로고    scopus 로고
    • Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness
    • Korytkowski MT, Mokan M, Veneman TE, Mitrakou A, Cryer PE, Gerich JE: Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness. Diabetes Care 21:1939-1943, 1998
    • (1998) Diabetes Care , vol.21 , pp. 1939-1943
    • Korytkowski, M.T.1    Mokan, M.2    Veneman, T.E.3    Mitrakou, A.4    Cryer, P.E.5    Gerich, J.E.6
  • 35
    • 0035340613 scopus 로고    scopus 로고
    • Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes
    • Fritsche A, Stefan N, Haring H, Gerich J, Stumvoll M: Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 134:729-736, 2001
    • (2001) Ann Intern Med , vol.134 , pp. 729-736
    • Fritsche, A.1    Stefan, N.2    Haring, H.3    Gerich, J.4    Stumvoll, M.5
  • 36
    • 0028237872 scopus 로고
    • Restoration of hypoglycemia awareness in patients with long-duration insulin-dependent diabetes
    • Cranston I, Lomas J, Maran A, Macdonald I, Amiel SA: Restoration of hypoglycemia awareness in patients with long-duration insulin-dependent diabetes. Lancet 344:283-287, 1994
    • (1994) Lancet , vol.344 , pp. 283-287
    • Cranston, I.1    Lomas, J.2    Maran, A.3    Macdonald, I.4    Amiel, S.A.5
  • 38
    • 0028608981 scopus 로고
    • Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM
    • Dagogo-Jack S, Rattarasarn C, Cryer PE: Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 43:1426-1434, 1994
    • (1994) Diabetes , vol.43 , pp. 1426-1434
    • Dagogo-Jack, S.1    Rattarasarn, C.2    Cryer, P.E.3
  • 39
    • 0034851707 scopus 로고    scopus 로고
    • Glucose counterregulation in type 2 diabetes mellitus
    • de Galan BE, Hoekstra JBL: Glucose counterregulation in type 2 diabetes mellitus. Diabet Med 18:519-527, 2001
    • (2001) Diabet Med , vol.18 , pp. 519-527
    • De Galan, B.E.1    Hoekstra, J.B.L.2
  • 40
    • 0036314189 scopus 로고    scopus 로고
    • Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
    • Segel SA, Paramore DS, Cryer PE: Hypoglycemia-associated autonomic failure in advanced type 2 diabetes. Diabetes 51:724-732, 2002
    • (2002) Diabetes , vol.51 , pp. 724-732
    • Segel, S.A.1    Paramore, D.S.2    Cryer, P.E.3
  • 41
    • 0025806276 scopus 로고
    • Epidemiology of severe hypoglycemia in the diabetes control and complication trial
    • The DCCT Research Group: Epidemiology of severe hypoglycemia in the diabetes control and complication trial. Am J Med 90:450-459, 1991
    • (1991) Am J Med , vol.90 , pp. 450-459
  • 42
    • 14644390624 scopus 로고    scopus 로고
    • Hypoglycemia in diabetes: Common, often unrecognized
    • Gabriely I, Shamoon H: Hypoglycemia in diabetes: common, often unrecognized. Cleveland Clin J Med 71:335-342, 2004
    • (2004) Cleveland Clin J Med , vol.71 , pp. 335-342
    • Gabriely, I.1    Shamoon, H.2
  • 43
    • 0009766506 scopus 로고    scopus 로고
    • Negotiating the barrier of hypoglycemia in diabetes
    • Cryer PE, Childs BP: Negotiating the barrier of hypoglycemia in diabetes. Diabetes Spectrum 15:20-27, 2002
    • (2002) Diabetes Spectrum , vol.15 , pp. 20-27
    • Cryer, P.E.1    Childs, B.P.2
  • 44
    • 0032861268 scopus 로고    scopus 로고
    • Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy
    • Heller SR, Amiel SA, Mansell P: Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycemia during intensified insulin therapy. Diabetes Care 22:1607-1611, 1999
    • (1999) Diabetes Care , vol.22 , pp. 1607-1611
    • Heller, S.R.1    Amiel, S.A.2    Mansell, P.3
  • 46
    • 0031794057 scopus 로고    scopus 로고
    • Risk factors of severe hypoglycemia in adult patients with type 1 diabetes - A prospective population based study
    • Muhlhause I, Overmann H, Bender R, Bott U, Berger M: Risk factors of severe hypoglycemia in adult patients with type 1 diabetes - a prospective population based study. Diabetologia 41:1274-1282, 1998
    • (1998) Diabetologia , vol.41 , pp. 1274-1282
    • Muhlhause, I.1    Overmann, H.2    Bender, R.3    Bott, U.4    Berger, M.5
  • 47
    • 0025958256 scopus 로고
    • The dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus: Magnitude, frequency, variability, and dependency on glucose counterregulation and insulin sensitivity
    • Perriello G, DeFeo P, Torlone E, Fanelli C, Santeusanio F, Brunetti P, Bolli GB: The dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus: magnitude, frequency, variability, and dependency on glucose counterregulation and insulin sensitivity. Diabetologia 34:21-28, 1991
    • (1991) Diabetologia , vol.34 , pp. 21-28
    • Perriello, G.1    DeFeo, P.2    Torlone, E.3    Fanelli, C.4    Santeusanio, F.5    Brunetti, P.6    Bolli, G.B.7
  • 48
    • 33748373646 scopus 로고    scopus 로고
    • Treat to target: ABCs for the elderly
    • Wright EE: Treat to target: ABCs for the elderly. DOC News 3:4, 2006
    • (2006) DOC News , vol.3 , pp. 4
    • Wright, E.E.1


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