Hypoglycemia associated autonomic failure

Clinical Autonomic Research

Volumn 12, Issue 5, 2002, Pages 358-365

  Diedrich, Laura ^a   Sandoval, Darleen ^a   Davis, Stephen N ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Counterregulation; Diabetes; Words hypoglycemia

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; DEOXYGLUCOSE; GLUCAGON; GLUCOCORTICOID; GROWTH HORMONE; HYDROCORTISONE; INSULIN; NORADRENALIN; PANCREAS POLYPEPTIDE;

ADDISON DISEASE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NEUROPATHY; BLOOD GLUCOSE MONITORING; DIABETES MELLITUS; DISEASE DURATION; EXERCISE; GLUCOSE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN METABOLISM; METABOLISM; MORTALITY; NERVE CONDUCTION; NEUROENDOCRINOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FUNCTION; REVIEW; RISK FACTOR; SEX DIFFERENCE; SYMPATHETIC NERVE; SYMPTOMATOLOGY; BLOOD; DIABETIC ANGIOPATHY; SEXUAL DEVELOPMENT;

AUTONOMIC NERVOUS SYSTEM DISEASES; DIABETES MELLITUS; DIABETIC ANGIOPATHIES; EXERCISE; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; SEX CHARACTERISTICS;

EID: 0036459943     PISSN: 09599851     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10286-002-0035-9     Document Type: Review

References (61)

1. UK Prospective Study Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352(9131):837-853
2. The Diabetes Control and Complications Trial Research Group (1997) Hypoglycaemia in the diabetes control and complication trial. Diabetes 46:271-286
3. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabtetes mellitus. N Engl J Med 329:977-986
4. Frizzell RT, Hendrick GK, Biggers DW, et al. (1988) Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes 37:749-759
5. DeFeo P, Perriello G, Torlone E, Ven-tura M, Santeusanio F (1989) Demonstration of a role for growth hormone in glucose counterregulation. Am J Physiol 256:E835-E843
6. DeFeo P, Perriello G, Torlone E, et al. (1989) Contribution of cortisol to glucose counterregulation in humans. Am J Physiol 257:E35-E42
7. Rizza RA, Cryer PE, Haymond MW, Gerich JE (1980) Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest 65:682-689
8. Hoffman RP, Sinkey CA, Anderson EA (1994) Hypoglycemia increases muscle sympathetic nerve activity in IDDM and control subjects. Diabetes Care 17:673-680
9. Gerich JE, Langlois M, Noacco C, Karam J, Forsham PH (1973) Lack of a glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha-cell defect. Science 182:171-173
10. Boyle P, Kempers S, O'Connor A, Nagy R (1995) Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N Engl J Med 333:1720-1731
11. Boyle PJ, Schwartz NS, Shah SD, Clutter WE, Cryer PE (1988) Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in non-diabetics. N Engl J Med 318:1487-1492
12. Cryer PE (1992) Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM Diabetes 41:255-260
13. Davis MR, Shamoon H (1991) Deficient counterregulatory hormone responses during hypoglycemia in a patient with insulinoma. J Clin Endocrinol Metab 72:788-792
14. Davis SN, Shavers C, Costa F (2000) Gender-related differences in counter-regulatory responses to antecedent hypoglycemia in normal humans. J Clin Endocrinol Metab 85:2148-2157
15. Davis SN, Shavers C, Mosqueda-Garcia R, Costa F (1997) Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans. Diabetes 46:1328-1335
16. Mitrakou A, Fanelli C, Veneman T, et al. (1993) Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 329:834-839
17. Dagogo-Jack S, Craft S, Cryer PE (1993) Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus. J Clin Invest 91:819-828
18. Cranston I, Lomas J, Maran A, Macdonald I, Amiel SA (1994) Restoration of hypoglycemia awareness in patients with long-duration insulin-dependent diabetes. Lancet 344:283-287
19. Dagogo-Jack S, Rattarasarn C, Cryer PE (1994) Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM Diabetes 43:1426-1434
20. Fanelli C, Epifano L, Rambotti AM, et al. (1993) Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM Diabetes 42:1683-1689
21. Korytkowski MT, Mokan M, Veneman TF, Mitrakou A, Cryer PE, Gerich JE (1998) Reduced beta-adrenergic sensitivity in patients with type 1 diabetes and hypoglycemia unawareness. Diabetes Care 21:1939-1943
22. Fritsche A, Stefan N, Haring H, Gerich J, Stumvoll M (2001) Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 134:729-736
23. Brown MR, Fisher LA (1986) Glucocorticoid suppression of the sympathetic nervous system and adrenal medulla. Life Sci 39:1003-1012
24. Komesaroff PA, Funder JW (1994) Differential glucocorticoid effects on catecholamine responses to stress. Am J Physiol 266:E118-E128
25. Kventansky R, Fukuhara K, Pacak K, Goldstein D, Kopin IJ (1993) Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats. Endocrinology 133:1411-1419
26. Robert-Thomason I, Johnsson JR, Panhall PR, Frewin DB (1991) Differential effect of glucocorticoids on abdominal pain induced by morphine. Pain 46:133-137
27. Picotti GB, Carrulra M, Ravazzani C, Cesura AM, Galva M, DaPrada M (1981) Plasma catecholamines in rats exposed to cold: Effect of ganglionic and adrenoreceptor blockade. Eur J Pharmacol 69:321-329
28. Udelsman R, Goldstein DS, Loriaux DL, Chrousos GP (1987) Catecholamine-glucocorticoid interactions during surgical stress. J Surg Res 43:539-545
29. Tappy L, Randin D, Vollenweider P, et al. (1994) Mechanisms of dexamethasone-induced insulin resistance in healthy humans. J Clin Endocrinol Metab 79:1063-1069
30. Davis SN, Shavers C, Costa F, Mosqueda-Garcia R (1996) Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal man. J Clin Invest 98:680-691
31. Davis SN, Shavers C, Costa F (1997) Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses. J Clin Invest 100:429-438
32. Ping L, Neill AR, Davis SN (2000) Administration of cortisone blunts autonomic nervous system (ANS) responses to subsequent hypoglycemia. Diabetes 49(S1):A66
33. Towler DA, Havlin CE, Craft S, Cryer P (1993) Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 42:1791-1798
34. Fanelli C, Pampanelli S, Epifano L, et al. (1994) Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM Diabetologia 37:1265-1276
35. Mitrakou A, Ryan C, Veneman T, et al. (1991) Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67-E74
36. Schwartz NS, Clutter WE, Shah SD, Cryer PE (1987) Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms. J Clin Invest 79:777-781
37. Cryer PE (1997) Hierarchy of physiological responses to hypoglycemia: Relevance to clinical hypoglycemia in type I (insulin dependent) diabetes mellitus. Horm Metab Res 29:92-96
38. Cryer PE (1999) Symptoms of hypo-glycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinol Metab Clin North Am 28:495-500v-vi
39. Davis MR, Mellman M, Friedman S, Chang CJ, Shamoon H (1994) Recovery of epinephrine response but not hypoglycemic symptom threshold after intensive therapy in Type I diabetes. Am J Med 97:535-542
40. Sacca L, Perez G, Carteni G, Rengo F (1977) Evaluation of the role of the sympathetic nervous system in the glucoregulatory response to insulin-induced hypoglycemia in the rat. Endocrinology 101:1016-1022
41. Davis SN, Shavers C, Costa F (2000) Differential gender responses to hypoglycemia are due to alterations in CNS drive and not glycemic thresholds. Am J Physiol Endocrinol Metab 279:E1054-E1063
42. Cryer PE (1999) Hypoglycemia is the limiting factor in the management of diabetes. Diabetes Metab Res Rev 15:42-46
43. Potter J, Clarke P, Gale EA, Dave SH, Tattersall RB (1982) Insulin-induced hypoglycaemia in an accident and emergency department: The tip of an iceberg? Br Med J (Clin Res Ed) 285:1180-1182
44. Segel SA, Fanelli CG, Dence CS, et al. (2001) Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 50:1911-1917
45. Heller SR, Cryer PE (1991) Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40:223-226
46. Davis MR, Shamoon H (1991) Conterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Metab 73:995-1001
47. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J (1993) Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42:1233-1237
48. Davis SN, Tate D (2001) Effects of morning hypoglycemia on neuroen-docrine and metabolic responses to subsequent afternoon hypoglycemia in normal man. J Clin Endocrinol Metab 86:2043-2050
49. Davis SN, Mann S, Galassetti P, et al. (2000) Effects of differing durations of antecedent hypoglycemia on counter-regulatory responses to subsequent hypoglycemia in normal humans. Diabetes 49:1897-1903
50. Davis SN, Fowler S, Costa F (2000) Hypoglycemic counterregulatory responses differ between men and women with type 1 diabetes. Diabetes 49:65-72
51. Davis SN, Shavers C, Costa F (2000) Gender-related differences in counterregulatory responses to antecedent hypoglycemia in normal humans. J Clin Endocrinol Metab 85:2148-2157
52. Diamond MP, Jones T, Caprio S, et al. (1993) Gender influences conterregulatory hormone responses to hypoglycemia. Metabolism 42:1568-1572
53. Davis SN, Galassetti P, Wasserman DH, Tate D (2000) Effects of antecedent hypoglycemia on subsequent counterregulatory responses to exercise. Diabetes 49:73-81
54. Galassetti P, Tate D, Neill RA, Morris PG, Davis SN (2001) Effect of antecedent hypoglycemia on neuroendocrine responses to subsequent exercise in Type 1 Diabetes. Diabetes 50(Supplement 2):A54
55. Rattarasarn C, Dagogo-Jack S, Zach-wieja J, Cryer PE (1994) Hypoglycemia-induced autonomic failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomic activation. Diabetes 43:809-818
56. Galassetti P, Mann S, Tate D, et al. (2001) Effects of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am J Physiol Endocrinol Metab 280:E908-E917
57. Galassetti P, Mann S, Tate D, Neill RA, Wasserman DH, Davis SN (2001) Effect of morning exercise on counterregulatory responses to subsequent, afternoon exercise. J Appl Physiol 91:91-99
58. Davis SN, Cherrington AD, Goldstein RE, Jacobs J, Price L (1993) Effects of insulin on the counterregulatory response to equivalent hypoglycemia in normal females. Am J Physiol 265:E680-E689
59. Davis SN, Galassetti P, Wasserman DH, Tate D (2000) Effect of gender on neuroendocrine and metabolic counterregulatory responses to exercise in normal man. J Clin Endocrinol Metab 85:224-230
60. Horton TJ, Pagliassotti MJ, Hobbs K, Hill JO (1998) Fuel metabolism in men and women during and after long-duration exercise. J Appl Physiol 85(5):1823-1832
61. Tarnopolsky L, MacDougall S, Atkinson S, Tarnopolski M, Sutton J (1990) Gender differences in substrate for endurance exercise. J Appl Physiol 68:302-308