Poor adherence to anti-inflammatory medication in asthma: Reasons, challenges, and strategies for improved disease management

Disease Management and Health Outcomes

Volumn 14, Issue 4, 2006, Pages 223-233

  Elliott, Rachel A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CROMOGLYCATE DISODIUM; LEUKOTRIENE RECEPTOR STIMULATING AGENT; THEOPHYLLINE;

ASTHMA; DEPRESSION; DRUG COST; ETHNOLOGY; EVIDENCE BASED PRACTICE; HUMAN; PATIENT AUTONOMY; PATIENT COMPLIANCE; PATIENT EDUCATION; PRESCRIPTION; REVIEW; SELF MEDICATION; SOCIAL SUPPORT; SOCIOECONOMICS; UNSPECIFIED SIDE EFFECT;

EID: 33748338585     PISSN: 11738790     EISSN: 11738790     Source Type: Journal    
DOI: 10.2165/00115677-200614040-00005     Document Type: Review

References (145)

1. US National Heart, Lung, and Blood Institute. Global initiative for asthma: global strategy for asthma management and prevention. National Institutes of Health publication no. 95-3659. Bethesda (MD): National Institutes of Health, 1995
2. UK Department of Health. Medicines and older people: implementing medicines-related aspects of the national service framework for older people [online]. London: Department of Health, 2001. Available from URL: http:// www.dh.gov.uk/assetRoot/04/06/72/47/04067247.pdf [Accessed 2006 Jul 4]
3. National Asthma Campaign. Out in the open: a true picture of asthma in the UK today. Asthma J 2001; 6 (3 Suppl.): 3-14
4. UK Department of Health. National service framework for older people [online]. London: Department of Health, 2001. Available from URL: http:// www.dh.gov.uk/assetRoot/04/07/12/83/04071283.pdf [Accessed 2006 Jul 4]
5. Weiss KB, Sullivan SD. The health economics of asthma and rhinitis: 1. Assessing the economic impact. J Allergy Clin Immunol 2001; 107: 3-8
6. Mannino DM, Homa DM, Akinbami LJ, et al. Surveillance for asthma: United States, 1980-1999. MMWR Surveill Summ 2002; 51: 1-13
7. American Lung Association Epidemiology and Statistics Unit. Trends in asthma morbidity and mortality [online]. New York: American Lung Association, 2005. Available from URL: http://www.lungusa.org/atf/cf/{7A8D42C2-FCCA-4604- 8ADE-7F5D5E762256}/ASTHMA1.PDF [Accessed 2006 Jul 4]
8. DiMatteo MR. Variations in patients' adherence to medical recommendations: quantitative review of 50 years of research. Med Care 2004; 42: 200-9
9. Cerveri I, Locatelli F, Zoia MC, et al. International variations in asthma treatment compliance. Eur Respir J 1999; 14: 288-94
10. Bender BG, Wamboldt FS, O'Connor SL, et al. Measurement of children's asthma medication adherence by self-report, mother report, canister weight, and Doser CT. Ann Allergy Asthma Immunol 2000; 85: 416-21
11. Bender BG, Milgrom H, Rand C, et al. Psychological factors associated with medication non-adherence in asthmatic children. J Asthma 1998; 35: 347-53
12. Milgrom H, Bender BG, Ackerson LM, et al. Children's compliance with inhaled asthma medications. J Allergy Clin Immunol 1995; 95: 217
13. Gibson NA, Ferguson AE, Aitchison TC, et al. Compliance with inhaled asthma medication in preschool children. Thorax 1995; 50: 1274-9
14. McQuaid EL, Kopel SJ, Klein RB, et al. Medication adherence in pediatric asthma: reasoning, responsibility, and behavior. J Pediatr Psychol 2003; 28: 323-33
15. Bauman LJ, Wright E, Leickly FE, et al. Relationship of adherence to pediatric asthma morbidity among inner-city children. Pediatrics 2002; 110: e6
16. Dartnell JGA, Anderson RP, Chohan V, et al. Hospitalisation for adverse events related to drug therapy: incidence, avoidability and costs. Med J Aust 1996; 164: 659-62
17. Psaty BM, Koepsell TD, Wagner EH, et al. The relative risk of incident coronary heart disease associated with recently stopping the use of β-blockers. JAMA 1990; 263 (12): 1653-7
18. Weiden PJ, Olfson M. Cost of relapse in schizophrenia. Schizophr Bull 1995; 21 (3): 419-29
19. Lau DT, Nau DP. Oral antihypoglycaemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabet Care 2004; 27: 2149-53
20. Balkrishnan R, Rajagopalan R, Camacho FT, et al. Predictors of medication adherence and associated health care costs in an older population with type diabetes mellitus: a longitudinal cohort study. Clin Ther 2003; 25 (11): 2958-71
21. Howard RL, Avery AJ, Howard PD, et al. Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study. Qual Saf Health Care 2003; 12: 280-5
22. Lewis A. Noncompliance: a $100 billion problem. Remington Report 1997; 5: 14-5
23. Zuger A. The 'other' drug problem: forgetting to take them. New York Times 1998 Jun 2
24. Coambs RB, Jarry JL, Jensen P, et al. Prescription non-compliance and inappropriate prescribing in Canada: causes, consequences and costs. Toronto (ON): Health Promotion Research, 1998
25. Greaves CJ, Hyland ME, Halpin DMG, et al. Patterns of corticosteroid medication use: non-adherence can be effective in milder asthma. Prim Care Respir J 2005; 14: 99-105
26. Cochrane MG, Bala MV, Downs KE, et al. Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique. Chest 2000; 117: 542-50
27. Braunstein GL, Trinquet G, Harper GE. Compliance with nedocromil sodium and nedocromil sodium/salbutamol combination. Eur Respir J 1996; 9: 893-8
28. Blais L, Suissa S, Boivin JF, et al. First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma. Thorax 1998; 53: 1025-9
29. Suissa S, Ernst P, Benayoun S, et al. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 2000; 343: 332-6
30. Williams LK, Pladevall M, Xi H, et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol 2004; 114: 1288-93
31. Milgrom H, Bender BG, Ackerson LM, et al. Noncompliance and treatment failure in children with asthma. J Allergy Clin Immunol 1996; 98: 1051-7
32. Birkhead G, Attaway NJ, Strunk RC, et al. Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications. J Allergy Clin Immunol 1989; 84: 484-91
33. Task Force on Medicines Partnership and the National Collaborative Medicines Management Services Programme. Room for review: a guide to medication review. The agenda for patients, practitioners and managers [online]. London, Medicines Partnership, 2002. Available from URL: http://www.medicines- partnership.org/medication-review/room-for-review [Accessed 2006 Jul 4]
34. Horne R, Weinman J. Patients' beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res 1999; 47 (6): 555-67
35. Horne R. Treatment perceptions and self regulation. In: Cameron D, Leventhal H, editors. The self-regulation of health and illness behaviour. London: Routledge, 2003: 138-53
36. Donovan J, Blake DR. Patient non-compliance: deviance or reasoned decision-making. Soc Sci Med 1992; 34: 507-13
37. Myers LB, Midence K. Methodological and conceptual issues in adherence. In: Myers LB, Midence K, editors. Adherence to treatment in medical conditions. Amsterdam: Harwood Academic Publishers, 1998: 1-25
38. Choo PW, Rand CS, Inui TS, et al. Validation of patient reports, automated pharmacy records, and pill counts with electonic monitoring of adherence to antihypertensive therapy. Med Care 1999; 37: 846-57
39. World Health Organization. Adherence to long-term therapies: evidence for action [online]. Geneva: World Health Organization, 2003. Available from URL: http://www.who.int/chronic_conditions/en/adherence_report.pdf [Accessed 2006 Jul 4]
40. Bender BG. Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires. Immunol Allergy Clin North Am 2005; 25: 107-30
41. Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates and health outcomes of medication adherence among seniors. Ann Pharmacother 2004; 38: 303-12
42. Kazis LE, Friedman RH. Improving medication compliance in the elderly. J Am Geriatr Soc 1988; 36: 1161-2
43. Diggory P, Fernandez C, Humphrey A, et al. Comparison of elderly people's technique in using two dry powder inhalers to deliver zanamivir: randomised controlled trial. BMJ 2001; 322: 1-4
44. Elizabeth JE. Problems elderly patients have using metered dose inhalers. Geriatr Med 1988; 19: 11-2
45. Armitage JM, Williams SJ. Inhaler technique in the elderly. Age Ageing 1988; 17: 275-8
46. Buston KM, Wood SF. Non-compliance amongst adolescents with asthma: listening to what they tell us about self-management. Fam Pract 2000; 17: 134-8
47. Apter AJ, Reisine ST, Affleck G, et al. Adherence with twice-daily dosing of inhaled steroids. Am J Respir Crit Care Med 1998; 157: 1810-7
48. Apter AJ, Boston RC, George M, et al. Modifiable barriers to adherence in inhaled steroids among adults with asthma: it's not just black and white. J Allergy Clin Immunol 2003; 111: 1219-26
49. Schillinger D, Piette JD, Grumbach J, et al. Closing the loop: physician communication with diabetic patients who have low health literacy. Arch Intern Med 2003; 163: 83-90
50. Donnelly JE, Donnelly WJ, Thong YH. Inadequate parental understanding of asthma medications. Ann Allergy 1989; 62: 337-41
51. Meyer IH, Sternfels P, Fagan JK, et al. Characteristics and correlates of asthma knowledge among emergency department users in Harlem. J Asthma 2001; 38: 531-8
52. Gilthorpe MS, Lay-Yee R, Wilson C, et al. Variations in hospitalization rates for asthma among Black and minority ethnic communities. Respir Med 1998; 92: 642-8
53. Halm EA, Wisnivesky JP, Leventhal H. Quality and access to care among a cohort of inner-city adults with asthma. Chest 2005; 128: 1943-50
54. Moudgil H, Honeybourne D. Differences in asthma management between White European and Indian subcontinent ethnic groups living in socioeconomically deprived areas in the Birmingham (UK) conurbation. Thorax 1998; 53: 490-4
55. Griffiths C, Kaur G, Gantley M, et al. Influences on hospital admission for asthma in south Asian and White adults: qualitative interview study. BMJ 2001; 323: 1-8
56. DiMatteo MR. Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol 2004; (2): 207-18
57. Meng A, McConnell S. Decision-making in children with asthma and their parents. J Am Acad Nurs Pract 2002; 14: 363-71
58. Chan P, DeBrune J. Parental concern towards the use of inhaled therapy in children with chronic asthma. Pediatr Int 2000; 42: 547-51
59. Farber HJ, Capra AM, Finkelstein JA, et al. Misunderstanding of asthma controller medications: association with nonadherence. J Asthma 2003; 40: 17-25
60. Irvine L, Crombie IK, Alder EM, et al. What predicts poor collection of medication among children with asthma? A case-control study. Eur Respir J 2002; 20: 1464-9
61. Fiese BH, Wamboldt FS, Anbar RD. Family asthma management routines: connections to medical adherence and quality of life. J Pediatr 2004; 146: 171-6
62. Penza-Clyve SM, Mansell C, McQuaid EL. Why don't children take their asthma medications? A qualitative analysis of children's perspectives on adherence. J Asthma 2004; 41: 189-97
63. DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 2000; 160 (14): 2101-7
64. Bartlett SJ, Krishnan JA, Riekert KA, et al. Maternal depressive symptoms and adherence to therapy in inner-city children with asthma. Pediatrics 2004; 113: 229-37
65. Strine TW. Risk behaviors and health-related quality of life among adults with asthma: the role of mental health status. Chest 2004; 126: 1849-54
66. Cluley S, Cochrane GM. Psychological disorder in asthma is associated with poor control and poor adherence to inhaled steroids. Respir Med 2001; 95: 37-9
67. Jessop DC, Rutter DR, Sharma D, et al. Emotion and adherence to treatment in people with asthma: an application of the emotional Stroop paradigm. Br J Psychol 2004; 95: 127-47
68. Chambers CV, Markson L, Diamond JJ, et al. Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices. Respir Med 1999; 93: 88-94
69. Rubin BK. Adherence to asthma therapy: the "blocked receptor". Pediatr Pulmonol 2004; 26 Suppl.: 36-7
70. Adams S, Pill R, Jones A. Medication, chronic illness and identity: the perspective of people with asthma. Soc Sci Med 1997; 45: 189-201
71. Pound P, Britten N, Morgan M, et al. Resisting medicines: a synthesis of qualitative studies of medicine taking. Soc Sci Med 2005; 61: 133-55
72. van Es SM, le Coq EM, Brouwer AI, et al. Adherence-related behavior in adolescents with asthma: results from focus group interviews. J Asthma 1998; 35: 637-46
73. Simoni-Wastila L, Ross-Degnan D, Mah C, et al. A retrospective data analysis of the impact of the New York triplicate prescription program on benzodiazepine use in Medicaid patients with chronic psychiatric and neurologic disorders. Clin Ther 2004; 26: 322-36
74. Dowell J, Hudson H. A qualitative study of medicine-taking behaviour in primary care. Fam Pract 1997; 14: 369-75
75. Garg VK, Bidani R, Rich EP, et al. Asthma patients' knowledge, perception, and adherence to the asthma guidelines. J Asthma 2005; 42: 633-8
76. Spector S. Noncompliance with asthma therapy: are there solutions? J Asthma 2000; 37 (5): 381-8
77. Rao VU, Apter AJ. Steroid phobia and adherence: problems, solutions, impact on benefit/risk profile. Immunol Allergy Clin North Am 2005; 25: 581-95
78. Boulet LP. Perception of the role and potential side effects of inhaled corticosteroids among asthmatic patients. Chest 1998; 113: 587-92
79. Riekert KA, Butz AM, Eggleston PA, et al. Caregiver-physician medication concordance and undertreatment of asthma among inner-city children. Pediatrics 2003; 111: E214-20
80. Fish L, Lung CL. Adherence to asthma therapy. Ann Allergy Asthma Immunol 2001; 86 Suppl. 6: 24-30
81. Cochrane GM, Horne R, Chavez P. Compliance in asthma. Respir Med 1999; 93: 763-9
82. Coutts JA, Gibson NA, Paton JY. Measuring compliance with inhaled medication to asthma. Arch Dis Child 1992; 67: 332-6
83. Chung KF, Kennelly C, Summerton L, et al. Compliance with an oral asthma treatment: electronic monitoring of twice-daily dosing with zafirlukast. Allergy Clin Immunol Int 1997; 9 Suppl. 4: 241
84. Edelman JM, Milewski KA, Turpin JA, et al. Effectiveness and safety of montelukast, a leukotriene receptor antagonist, compared to inhaled Cromolyn in moderate asthmatic children ages 6 to 11. J Allergy Clin Immunol 1999; 130: S134
85. Kelloway JS, Wyatt RA, Adlis SA. Comparison of patients' compliance with prescribed oral and inhaled asthma medications. Arch Intern Med 1994; 154: 1349-52
86. Ringdal N, Whitney JG, Summerton L. A comparison of patient preferences for treatment with oral zafirlukast or inhaled beclomethasone. Eur Respir J 1997; 10 Suppl. 25: 437S
87. Weinberg EG, Summerton L, Harris A. Assessment of preference for oral zafirlukast vs inhaled beclomethasone in adolescent asthmatics. Eur Respir J 1998; 12 Suppl. 28: 36S
88. Bukstein DA, Bratton DL, Firriolo KM, et al. Evaluation of parental preference for the treatment of asthmatic children aged 6 to 11 years with oral montelukast or inhaled Cromolyn: a randomised, open-label, crossover study. J Asthma 2003; 40: 475-85
89. Dompeling E, van Grunsven PM, van Schayck CP, et al. Treatment with inhaled steroids in asthma and chronic bronchitis: long term compliance and inhaler technique. Fam Pract 1992; 9: 161-7
90. Celano M, Geller RJ, Philips KM, et al. Treatment adherence among low-income children with asthma. J Pediatr Psychol 1998; 23: 345-9
91. Jones VA, Fernandez C, Diggory P. A randomised prospective comparison of inhaler technique among elderly people using one of: Easi-breathe, turbohaler or metered dose inhaler and Volumatic inhalers for the first time. Age Ageing 1999; 28: 481-4
92. Chaney G, Clements B, Landau L, et al. A new asthma spacer device to improve compliance in children: a pilot study. Respirology 2004; 9: 499-506
93. Chapman KR, Love L, Brubaker H. A comparison of breath-actuated and conventional metered dose inhaler techniques in elderly subjects. Chest 2006; 104: 1332-7
94. Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin Ther 1984; 6: 592-9
95. Chung KF, Naya I. Compliance with an oral asthma medication: a pilot study using an electronic monitoring device. Respir Med 2000; 94: 852-8
96. Carter ER, Ananthakrishnan M. Adherence to montelukast versus inhaled corticosteroids in children with asthma. Pediatr Pulmonol 2003; 36: 301-4
97. Bateman ED, Aitchison JA, Summerton L, et al. The early onset of action of zafirlukast (Accolate) in patients with asthma. Am J Respir Crit Care Med 1997; 155: A663
98. Darnell JC, Murray MD, Martz BL, et al. Medication use by ambulatory elderly: an in-home survey. J Am Geriatr Soc 1986; 34: 1-4
99. McElnay JC, McCallion CR, al Deagi F, et al. Self-reported medication noncompliance in the elderly. Europ J Clin Pharmacol 1997; 53: 171-8
100. Coons SJ, Sheahan SL, Martin SS, et al. Predictors of medication noncompliance in a sample of older adults. Clin Ther 1994; 16: 110-7
101. Avorn J, Monette J, Lacour A, et al. Persistence of use of lipid-lowering medications: a cross-national study. JAMA 1998; 279: 1458-62
102. Gurwitz JH, Glynn RJ, Monane M, et al. Treatment for glaucoma: adherence by the elderly. American Journal of Public Health 1993; 83: 711-6
103. Monane M, Bohn RL, Gurwitz JH, et al. The effects of initial drug choice and comorbidity on antihypertensive therapy compliance: results from a population-based study in the elderly. Am J Hypertens 1997; 10: 697-704
104. Cox ER, Henderson RR. Prescription use behaviour among Medicare beneficiaries with capped prescription benefits. J Manag Care Pharm 2002; 8: 360-4
105. Fortess EE, Soumerai SB, McLaughlin TJ, et al. Utilization of essential medications by vulnerable older people after a drug benefit cap: importance of mental disorders, chronic pain and practice setting. J Am Geriatr Soc 2001; 49: 793-7
106. Piette JD, Heisler M, Wagner TH. Cost-related medication underuse: do patients with chronic illnesses tell their doctors? Arch Intern Med 2004; 164: 1749-55
107. Schafheutle EI, Hassell K, Noyce PR, et al. Access to medicines: cost as an influence on the views and behaviour of patients. Health Soc Care Community 2002; 10: 187-95
108. Soumerai SB. Unintended outcomes of Medicaid drug cost-containment policies on the chronically mentally ill. J Clin Psychiatry 2003; 64 Suppl. 17: 19-22
109. Stempel DA, Stoloff SW, Rosenzweig JRC, et al. Adherence to asthma controller medication regimens. Respir Med 2005; 99: 1263-7
110. Stoloff SW, Stempel DA, Meyer J, et al. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 2004; 113: 245-51
111. Bosley CM, Parry DT, Cochrane GM. Patient compliance with inhaled medication: does combining beta-agonists with corticosteroids improve compliance? Eur Respir J 1994; 7: 504-9
112. van der Palen J, Klein JJ, Rovers MM. Compliance with inhaled medication and self-treatment guidelines following a self-management programme in adult asthmatics. Eur Respir J 1997; 10: 652-7
113. Soumerai SB, Avorn J, Ross-Degnan D, et al. Payment restrictions for prescription drugs under Medicaid: effects on therapy, cost, and equity. N Engl J Med 1987; 317: 550-6
114. Tamblyn R, Laprise R, Hanley JA, et al. Adverse events associated with prescription drug cost-sharing among poor and elderly persons. JAMA 2001; 285: 421-9
115. Strickland WJ, Hanson CM. Coping with the cost of prescription drugs. J Health Care Poor Underserved 1996; 7: 50-62
116. Phelps L. Unhealthy charges: CAB evidence on the impact of health charges [online]. London: National Association of Citizens Advice Bureaux, 2001. Available from URL: http://www.citizensadvice.org.uk/unhealthy-charges.pdf [Accessed 2006 Jul 4]
117. Schafheutle EI, Hassell K, Seston EM, et al. Non-dispensing of NHS prescriptions in community pharmacies. Int J Pharm Pract 2002; 10: 11-5
118. Asthma UK. New figures for UK asthma [online]. London: Asthma UK, 2004. Available from URL: http://www.asthma.org.uk/news_media/news/ new_figures_for.html [Accessed 2006 Jul 4]
119. Safran DG, Taira DA, Rogers WH, et al. Linking primary care performance to outcomes of care. J Fam Pract 1998; 47: 213-20
120. Adams RJ, Smith BJ, Ruffin RE. Patient preferences for autonomy in decision-making in asthma management. Thorax 2001; 56: 126-32
121. Adams RJ, Smith BJ, Ruffin RE. Factors associated with hospital admissions and repeat emergency department visits for adults with asthma. Thorax 2000; 55: 566-73
122. Coulter A. The autonomous patient: ending paternalism in health care. London: The Nuffield Trust, 2002
123. Medicines Partnership. Medicines Partnership: from compliance to concordance. London: Medicines Partnership, 2002
124. Carter S, Taylor D, Levenson R. A question of choice - compliance in medicine taking [online]. London: Medicines Partnership, 2005. Available from URL: http://www.medicines-partnership.org/research-evidence/major-reviews/a- question-of-choice [Accessed 2006 Jul 4]
125. Goerman DP, Hogan CD, Aroni RA, et al. Barriers to delivering asthma care: a qualitative study of general practitioners. Med J Aust 2005; 183: 457-60
126. Broers S, Smets E, Bindels P, et al. Training general practitioners in behavior change counseling to improve asthma medication adherence. Patient Educ Couns 2005; 58: 279-87
127. Bender BG, Milgrom H, Apter AJ. Adherence intervention research: what have we learned and what do we do next? J Allergy Clin Immunol 2003; 112: 489-94
128. Nichol MB, Venturini F, Sung JCY. A critical evaluation of the methodology of the literature on medication compliance. Ann Pharmacother 1999; 33: 531-40
129. Haynes RB, McKibbon KA, Kanani R. Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications. Lancet 1996; 348: 383-6
130. Bonner S, Zimmerman BJ, Evans D, et al. An individualised intervention to improve asthma management among urban Latino and African-American families. J Asthma 2002; 39: 493-500
131. Elliott RA, Barber N, Horne R. Cost-effectiveness of adherence-enhancing interventions: a quality assessment of the evidence. Ann Pharmacother 2005; 39: 508-15
132. Bolton MB, Tilley BC, Kuder J, et al. The cost and effectiveness of an education program for adults who have asthma. J Gen Intern Med 1991; 6: 401-7
133. Clark NM, Feldman CH, Evans D, et al. The effectiveness of education for family management of asthma in children: a preliminary report. Health Educ Q 1981; 8 (2): 166-74
134. Deter HC. Cost-benefit analysis of psychosomatic therapy in asthma. J Psychosom Res 1986; 30 (2): 173-82
135. Lewis CE, Rachelefsky G, Lewis MA, et al. A randomized trial of ACT (asthma care training) for kids. Pediatrics 1984; 74: 478-86
136. Neri M, Migliori GB, Spanavello A, et al. Economic analysis of two structured treatment and teaching programs on asthma. Allergy 1996; 51: 313-9
137. Sondergaard B, Davidsen F, Kirkeby B, et al. The economics of an intensive education programme for asthmatic patients: a prospective controlled trial. PharmacoEconomics 1992; 1 (3): 207-12
138. Barbanel D, Eldridge S, Griffiths C. Can a self-management programme delivered by a community pharmacist improve asthma control? A randomised trial. Thorax 2003; 58 (10): 851-4
139. Levy ML, Robb M, Allen J, et al. A randomized controlled evaluation of specialist nurse education following accident and emergency department attendance for acute asthma. Respir Med 2000; 94 (9): 900-8
140. Gallefoss FROD, Bakke PS. How does patient education and self-management among asthmatics and patients with chronic obstructive pulmonary disease affect medication? Am J Respir Crit Care Med 1999; 160 (6): 2000-5
141. Devine E. Meta-analysis of the effects of psychoeducational care in adults with asthma. Res Nurs Health 1996; 19: 367-76
142. Put C, van den Bergh O, Lemaigre V, et al. Evaluation of an individualised asthma programme directed at behavioural change. Eur Respir J 2003; 21: 109-15
143. Osman L. How do patients' views about medication affect their self-management in asthma? Patient Educ Couns 1997; 32: S43-9
144. Smith JR, Mildenhall S, Noble MJ, et al. Clinician-assessed poor compliance identifies adults with severe asthma who are at risk of adverse outcomes. J Asthma 2005; 42: 437-45
145. Rand CS. Non-adherence with asthma therapy: more than just forgetting. J Pediatr 2005; 146: 157-9