Serum free light chain specificity and sensitivity: A reality check

Clinical Chemistry

Volumn 52, Issue 9, 2006, Pages 1638-1639

  Katzmann, Jerry A ^a  

^a Mayo Clinic College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

B LYMPHOCYTE; CAPILLARY ELECTROPHORESIS; CLINICAL CHEMISTRY; CLINICAL LABORATORY; DIAGNOSTIC ACCURACY; EDITORIAL; HUMAN; IMMUNOASSAY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PLASMA CELL; REFERENCE VALUE; SERUM; URINALYSIS;

BENCE JONES PROTEIN; BLOOD PROTEIN ELECTROPHORESIS; HUMANS; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; PARAPROTEINEMIAS; SENSITIVITY AND SPECIFICITY; SERUM;

EID: 33748334356     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.072041     Document Type: Editorial

References (10)

1. Bradwell AR, Carr-Smith HD, Mead GP, Tang LX, Showell PJ, Drayson MT et al. Highly sensitive automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-80.
2. Katzmann JA, Clark RJ, Abraham RS, Bryant S, Lymp JF, Bradwell AR et al. Serum reference intervals and diagnostic ranges for free κ and free λimmunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002;48:1437-44.
3. Lachmann HJ, Gallimore R, Gillmore JD, Carr-Smith HD, Bradwell AR, Pepys MB et al. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol 2003;122:78-84.
4. Abraham RS, Katzmann JA, Clark RC, Bradwell AR, KyIe RA, Gertz MA. Quantitative analysis of serum free light chains. A new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol 2003;119:274-8.
5. Drayson MT, Tang LX, Drew R, Mead GP, Carr-Smith HD, Bradwell AR. Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood 2001;97:2900-2.
6. Katzmann JA, Abraham RS, Dispenzieri A, Lust JA, Kyle RA. Diagnostic performance of quantitative serum free light chain assays in clinical practice. Clin Chem 2005;51:878-81.
7. Bradwell AR. Serum free light chain measurements move to center stage. Clin Chem 2005;51:805-7.
8. Kyle RA. The International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57.
9. Hill PG, Forsyth JM, Rai B, Mayne S. Serum free light chains: an alternative test to urine Bence Jones proteins when screening for monoclonal gammopathies. Clin Chem 2006;52:1743-8.
10. Bakshi NA, Gulbranson R, Garstka D, Bradwell AR, Keren DF. Serum free light chain (FLC) measurement can aid capillary zone electrophoresis in detecting subtle FLC-producing M-proteins. Am J Clin Pathol 2005;124:214-8.