Abnormal saccadic distractibility in patients with schizophrenia: A 99mTc-HMPAO SPET study

Psychological Medicine

Volumn 26, Issue 2, 1996, Pages 265-277

  Crawford, T J ^a   Puri, B K ^b   Nijran, K S ^b   Jones, B ^b   Kennard, C ^b   Lewis, S W ^b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; NEUROLEPTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN TOMOGRAPHY; CINGULATE GYRUS; CLINICAL ARTICLE; CORPUS STRIATUM; HUMAN; INSULA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEURORADIOLOGY; PHOTON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; AROUSAL; ATTENTION; BRAIN; BRAIN MAPPING; DOMINANCE, CEREBRAL; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; ORGANOTECHNETIUM COMPOUNDS; OXIMES; PREFRONTAL CORTEX; REFERENCE VALUES; REFLEX; REGIONAL BLOOD FLOW; SACCADES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0029995192     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0033291700034668     Document Type: Article

References (79)

1. Albin, R. L , Young, A B & Penney, J. B. (1989). The functional anatomy of basal ganglia disorders Trends in Neurosciences 12, 366-375.
2. Alexander, G. E., Delong, M R. & Strick, P. L. (1986). Parallel organisation of functionally segregated circuits linking basal ganglia and cortex Annual Review of Neurosciences 9, 357-381
3. Anderson, T. J , Jenkins, I. H., Brooks, D. J , Hawken, M. B , Frackowiak, R. S. J. & Kennard, C (1994). Cortical control of saccades and fixation in man: a positron emission tomographic study. Brain 117, 1073-1084.
4. Andreasen, N C (1984a) Schedule for the Assessment of Negative Symptoms (SANS). University of Iowa: Iowa City.
5. Andreasen, N. C. (1984b) Schedule for the Assessment of Positive Symptoms (SAPS) University of Iowa: Iowa City.
6. Annett, M (1970) Classification of hand preference by association analysis British Journal of Psychology 61, 303-321.
7. Bailey, D L, Jones, T , Friston, K. J, Colebatch, J. G & Frackowiak, R. S. J. (1991). Physical validation of statistical parametric analysis. Journal of Cerebral Blood Flow 11, S150.
8. Bronstein, A. M. & Kennard, C. (1985). Predictive ocular motor control in Parkinson's disease. Brain 108, 925-940.
9. Bruce, C. J. & Goldberg, M. E. (1985). Primate frontal eye fields. I. Single neurones discharging before saccades. Journal of Neurophysiology 53, 603-635
10. Bruce, C. J., Goldberg, M. E., Bushnell, M. C. & Stanton, G. B. (1985). Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. Journal of Neurophysiology 54, 714-734
11. Carpenter, R. H. S. (1988). Movement of the Eyes Pion: London
12. Chollet, F , Dipiero, V., Wise, R. J. S., Brooks, D. J., Dolan R. J. & Frackowiak, R. S. J. (1991). The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Annals of Neurology 29, 63-71.
13. Clementz, B. A. & Sweeney, J. A. (1990). Is eye movement dysfunction a biological marker for schizophrenia? A methodological review. Psychological Bulletin 108, 77-92.
14. Cohen, R. M., Semple, W. E., Gross, M., Nordahl, T. E., De Lisi, L. E., Holcomb, H. H., King, A. C., Morihisa, J. M. & Pickar, D. (1987) Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences 20, 2031-2039
15. Cohen, R. M., Semple, W. E., Gross M. & Nordahl, T. E. (1988). From syndrome to illness, delineating the pathology of schizophrenia with PET. Schizophrenia Bulletin 14, 169-176
16. Colebatch, J. G , Deiber, M. P. Passingham, R. E., Friston, K. J. & Frackowiak, R. S. J. (1991). Regional cerebral blood flow during voluntary arm and hand movements in human subjects. Journal of Neurophysiology 65, 1392-1401.
17. Crawford, T J., Henderson, L. & Kennard, C. (1989a). Abnormalities of nonvisually-guided eye movements in Parkinson's disease. Brain 112, 1573-1586
18. Crawford, T. J., Goodrich, S., Henderson, L. & Kennard, C. (1989b). Predictive responses in Parkinson's disease: manual keypresses and saccadic eye movements to regular stimulus events. Journal of Neurology, Neurosurgery and Psychiatry 52, 1033-1042.
19. Crawford, T. J., Haegar, B., Kennard, C., Reveley, M. A. & Henderson, L. (1995a). Saccadic abnormalities in psychotic patients. I. Neuroleptic-free psychotic patients Psychological Medicine 25, 461-471.
20. Crawford, T J., Haegar, B., Kennard, C., Reveley, M. A. & Henderson, L (1995b). Saccadic abnormalities in psychotic patients. II The role of neuroleptic treatment. Psychological Medicine 25, 473-483.
21. Degos, J. D., Fonseca, N. da, Gray, F. & Cesaro, P. (1993). Severe frontal syndrome associated with infarcts of the left anterior cingulate gyrus and the head of the right caudate nucleus. A clinico-pathological case Brain 116, 1541-1548.
22. Deiber, M. P , Passingham, R. E., Colebatch, J. G., Fristen, K. J., Nixon, P. D. & Frackowiak R S. J. (1991). Cortical areas and the selection of movement: a study with positron emission tomography. Experimental Brain Research 84, 393-402.
23. Diefendorf, A. R. & Dodge, R (1908). An experimental study of the ocular reactions of the insane from photographic records. Brain 31, 451-489.
24. Folstein, M. F., Folstein, S E. & McHugh, P. R. (1975). 'Mini-mental state.' A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189-198.
25. Fox, P T , Fox, J. M., Raichle, M. E. & Burde, R. M. (1985). The role of the cerebral cortex in the generation of voluntary saccades: a positron emission tomographic study. Journal of Neurophysiology 54, 348-369.
26. Friston, K. J., Passingham, R. E , Nutt, J. G., Heather, J. D., Sawle, G V. & Frackowiak, R. S J. (1989). Localisation in PET images: direct fitting of the intercommisural (AC-PC) line. Journal of Cerebral Blood Flow and Metabolism 9, 690-695.
27. Friston, K. J., Frith, C. D., Liddle, P. F., Dolan, R. J., Lammertsma, A. A & Frackowiak, R. S. J. (1990). The relationship between global and local changes in PET scans Journal of Cerebral Blood Flow and Metabolism 10, 458-466.
28. Friston, K. J., Frith, C. D , Liddle, P. F. & Frackowiak, R. S. J. (1991a). Comparing functional (PET) images: the assessment of significant change. Journal of Cerebral Blood Flow and Metabolism 11, 690-699.
29. Friston, K. J., Frith, C. D., Liddle, P. F. & Frackowiak, R. S. J. (1991b). Plastic transformation of PET images. Journal of Computer Assisted Tomography 15, 634-639
30. Frith, C. D., Friston, K , Liddle, P. F. & Frackowiak, R. S. J. (1991). Willed action and the prefrontal cortex in man: a study with PET. Proceedings of the Royal Society London, B 244, 241-246.
31. Fukushima, J., Fukishima, K., Nobuyuki, M. & Yamashita, I. (1990) Further analysis of the control of voluntary saccadic eye movements in schizophrenic patients. Biological Psychiatry 28, 943-958.
32. Funahashi, S., Brace, C. J. & Goldman-Rakic, P. S. (1989). Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. Journal of Neurophysiology 61, 331-349.
33. Funahashi, S., Chafee, M. & Goldman-Rakic, P. S. (1993). Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task Nature 365, 753-756.
34. Gnadt, J. W., Anderson, R. A. & Blatt, G. J. (1986). Spatial memory and planning properties of saccade related activity in the lateral intraparietal area of the macaque. Society of Neuroscience Abstracts 12, 458.
35. Guitton, D., Buchtal, H. A. & Douglas, R. M. (1985). Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal directed saccades. Experimental Brain Research 58, 453-474.
36. Gurevich, B. Kh. (1961). Universal characteristics of fixation eye jerks, change in fixation as a cybernetic model of directed behaviour. Biophysics 6, 419-427.
37. Hallet, P. E. & Adams, B D. (1980). The predictability of saccadic latency in a novel voluntary oculomotor task. Vision Research 20, 329-339.
38. 15O. I Theory and error analysis. Journal of Nuclear Medicine 24, 782-789.
39. Hikosaka, O. & Wurtz, R. H. (1983a). Visual and oculomotor functions of monkey substantia nigra, pars reticulata. I. Relation of visual and auditory responses to saccades. Journal of Neurophysiology 49, 1230-1253.
40. Hikosaka, O & Wurtz, R. H. (1983b). Visual and oculomotor functions of monkey substantia nigra, pars reticulata. IV Relation of substantia nigra to superior colliculus. Journal of Neurophysiology 49, 1285-1301.
41. Hikosaka, O. & Wurtz, R. H. (1985). Modification of saccadic eye movements GABA-related substances I. Effect of muscimol and bicucculine in monkey superior colliculus. Journal of Neurophysiology 53, 266-291.
42. Holzman, P. S., Proctor, L. R., Levy, D. L., Yasillo, N. J., Meltzer, H. Y. & Hurt, S. W (1974). Eye-tracking dysfunctions and schizophrenic patients and their relatives. Archives of General Psychiatry 31, 143-151
43. Jarritt, P. H. & Ell, P. J (1984). Gamma Camera Emission Tomography Quality Control and Clinical Applications Current Medical Literature. London.
44. Jenkins, I H., Passingham, R. E., Frackowiak, R. S. J. & Brooks, D. J (1994). The effect of movement rate on cerebral activation a study with positron emission tomography. Movement Disorders 9, suppl 1, p 486.
45. Kennard, C., Crawford, T. J. & Henderson, L. (1994) A pathophysiological approach to eye movement abnormalities in neurological and psychiatric disease. Journal of Neurology, Neurosurgery and Psychiatry 57, 881-885.
46. Krawieka, M., Goldberg, D. & Vaughan, M. (1977) A standardized psychiatric assessment for rating chronic psychotic patients. Acta Psychiatrica Scandinavica 55, 299-308.
47. Kunzle, H. (1978). An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (area 6 and 9) in Macaca fascicularis. Brain Behaviour Evolution 15, 185-234.
48. Kunzle, H & Akert, K. (1977) Efferent connections of area 8 (frontal eye field) in Macaca fascicularis. A reinvesugation using the autoradiographic technique. Journal of Comparative Neurology 173, 147-164
49. Laplane, D , Degos, J. D., Baulac, M. & Gray, F. (1981). Bilateral infarction of the anterior cingulate gyri and the fornices. Report of a case. Journal of Neurological Sciences 51, 300.
50. Lasker, A. G., Zee, D. S , Hain, T. C., Folstein, S. E & Singer, H. S. (1987). Saccades in Huntington's disease initiation defects and distractibility. Neurology 37, 364-370.
51. Lassen, N. A., Anderson, R. A , Friberg, H. & Paulson, O. B. (1988). The retention of 99m-Tc HMPAO in the human brain after intracarotid bolus injection: a kinetic analysis. Journal of Cerebral Blood Flow and Metabolism 8, 513-522.
52. Lewis, S. W., Ford, R. A., Syed, G. M., Reveley, A. M. & Toone, B. K. (1992). A controlled study of 99m Tc-HMPAO single-photon emission imaging in chronic schizophrenia Psychological Medicine 22, 27-35.
53. Lueck, C J., Tanyen, S., Crawford, T. J., Henderson, L. & Kennard, C (1990). Antisaccades and remembered saccades in Parkinson's disease Journal of Neurology, Neurosurgery and Psychiatry 53, 284-288.
54. Mesulam, M. M. & Mufson, E. J. (1987). The insula of Reil in man and monkey Architectonics, connectivity and function. In Cerebral Cortex 4 (ed. E. J. Jones and A. Peters), pp. 179-226. Plenum Press: New York.
55. Nakashima, Y , Momose, T , Sano, I., Katayama, S , Nakajima, T., Niwa, S & Matsushita, M (1994). Cortical control of saccade in normal and schizophrenic subjects: a PET study using a task-evoked rCBF paradigm. Schizophrenia Research 12, 259-264.
56. Nelson, H. & O'Connell, A. (1978). Dementia: the estimation of premorbid intelligence using the new Adult Reading Test. Cortex 14, 234-244
57. O'Driscoll, G A., Alpert, N. M., Matthyse, S., Levy, D. & Holzman, P. S. (1994). The neural substrates of antisaccade performance implicate oculomotor circuit dysfunction in schizophrenia. Schizophrenia Research 11, 149.
58. O'Sullivan, E. P., Jenkins, I. H., Henderson, L., Kennard, C. & Brooks, D J. (1995) The functional anatomy of remembered saccades a PET study. Neuroreport 1995 (in the press).
59. Park, S. & Holzman, P. S. (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry 49, 975-982.
60. Park, S. & Holzman, P. S (1993). Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophrenia Research 11, 55-61.
61. Paus, T , Kalina, M., Patockova, L , Angerova, Y., Cerny, R., Mecir, P., Bauer, J & Krabec, P. (1991) Medical v lateral frontal lobe lesions and differential impairment of central-gaze fixation maintenance in man. Brain 114, 2051-2067
62. Paus, T., Petrides, M., Evan, A. C. & Meyer, E. (1993). Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study. Journal of Neurophysiology 70, 453-469.
63. Petit, L , Orssau, C., Tzourio, N , Salamon, G., Mazoyer, B. & Berthoz, A. (1993). PET study of the voluntary saccadic eye movements in humans: basal ganglia-thalamocortical system and cingulate cortex involvement. Journal of Neurophysiology 69, 1009-1017
64. Pierrot-Deseilligny, C. H , Rivaud, S., Gaymaud, B & Agid, Y. (1991). Cortical control of reflexive visually-guided saccades. Brain 114, 1473-1485.
65. Posner, M. I., Petersen, S. E., Fox, P. T & Raichle, M. E (1988). Localization of cognitive operations in the human brain. Science 240, 1627-1631.
66. 15O. II. Implementation and validation. Journal of Nuclear Medicine 24, 790-798.
67. Rosse, R. B., Schwartz, B. L., Kim, S. Y. & Deutsch, S. I. (1993). Correlation between antisaccades and Wisconsin card sorting test performance in schizophrenia. American Journal of Psychiatry 150, 333-335.
68. Sabatini, U., Chollet, F , Rascol, O., Celsis, P., Rascol, A., Lenzi, L. & Marc-Vergnes, J. P. (1993). Effect of side and rate of stimulation on cerebral blood flow changes in motor areas during finger movement in humans. Journal of Cerebral Blood Flow and Metabolism 13, 639-645.
69. Schwartz, M. L. & Goldman-Rakic, P. S. (1982). Single neurons have axon collaterals to ipsilateral and contralateral cortex in fetal and adult primates. Nature 299, 154-156.
70. Selemon, L. D. & Goldman-Rakic, P. S. (1988). Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behaviour Journal of Neuroscience 8, 4049-4068.
71. Showers, M. J. C & Lauer, E W. (1961). Somatovisceral motor patterns in the insula. Journal of Comparative Neurology 117, 107-116.
72. Stanton, G. B., Goldberg, M. E. & Bruce, C. J. (1988a). Frontal eye field efferents in the macaque monkey. II Topography of terminal fields in midbrain and pons. Journal of Comparative Neurology 271, 493-506.
73. Stanton, G. B., Goldberg, M E. & Bruce, C. J. (1988b) Frontal eye field efferents in the macaque monkey. I. Subcortical pathways and topography of striatal and thalamic terminal fields. Journal of Comparative Neurology 271, 473-492.
74. Sugar, O., Chusid, J G. & French, J. D (1948). A second motor cortex in the monkey (Macaca mulatta). Journal of Neuropathology and Experimental Neurology 7, 182-189.
75. Talairach, J. & Tournoux, P (1988). Co-planar Stereotaxic Atlas of the Human Brain. Thieme: Stuttgart.
76. Thaker, G K , Nguyen, J. A. & Tamminga, C A. (1989). Increased saccadic distractibility in tardive dyskinesia: functional evidence for subcortical GABA dysfunction Biological Psychiatry 25, 45-59.
77. Weinberger, D. R., Berman, K. F. & Zec, R. F. (1986) Physiologic function of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence Archives of General Psychiatry 43, 114-124
78. Yeterian, E H. & Van Hoesen, F. W. (1978). Cortico-striate projections in the rhesus monkey the organization of certain cortico-caudate connections. Brain Research 139, 43-63.
79. Zee, D. S. (1984). Ocular motor control, the cerebral control of saccadic eye movements. In Neuro-Ophthalmology 3 (ed. S Lessell and J. T W. van Dalen), pp 141-156. Elsevier: Amsterdam.