Relative contribution of V-H+ATPase and NA+/ H+ exchanger to bicarbonate reabsorption in proximal convoluted tubules of old rats

Aging Cell

Volumn 5, Issue 5, 2006, Pages 367-372

  Fiori, Mariana ^a,c   Radrizzani, Martín ^c,d   Díaz sylvester, Paula ^a   Müller, Angélica ^b   Corti, Tomás ^a   Monserrat, Alberto ^c   Amorena, Carlos ^a  

^a UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

Author keywords

Aging; Kidney; Micropuncture experiments; Na+ H+ exchange; V H+ ATPase; Western blot

Indexed keywords

AMILORIDE DERIVATIVE; BAFILOMYCIN; BICARBONATE; ISOPROTEIN; PROTEIN ANTIBODY; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; IN VITRO STUDY; KIDNEY ACIDIFYING CAPACITY; KIDNEY PROXIMAL TUBULE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PUNCH BIOPSY; RAT; WESTERN BLOTTING;

AGING; AMILORIDE; ANIMALS; BICARBONATES; BLOTTING, WESTERN; HYDROGEN-ION CONCENTRATION; KIDNEY TUBULES, PROXIMAL; MICROVILLI; RATS; SODIUM CHANNEL BLOCKERS; SODIUM-HYDROGEN ANTIPORTER; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 33748325673     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2006.00229.x     Document Type: Article

References (38)

1. Amorena C, Castro AF (1997) Control of proximal tubule acidification by the endothelium of the peritubular capillaries. Am. J. Physiol. Regul. Integr. Comp. Physiol. 272, R691-R694.
2. Amorena C, Fernandes D, Malnic G (1984) Factors affecting proximal tubular acidification of non-bicarbonate buffers. J. Physiol. (Lond.) 352, 31-48.
3. 1 receptors. Am. J. Physiol. Renal Physiol. 287, F789-F796.
4. Bank N, Aynedjain AS (1976) A micropuncture study of the effect of parathyroid hormone on renal bicarbonate reabsorption. J. Clin. Invest. 58, 336-344.
5. Bank N, Aynedjian HS, Mutz BF (1985) Evidence for a DCCD-sensitive component of proximal bicarbonate reabsorption. Am. J. Physiol. 249, F636-F644.
6. Baum M (1992) Developmental changes in rabbit juxtamedullary proximal convoluted tubule acidification. Pediatr. Res. 31 (4 Part 1), 411-414.
7. Baylis C (1994) Age dependent glomerular damage in the rat. J. Clin. Invest. 94, 1823-1829.
8. Choi JY, Shah M, Lee MG, Schultheis PJ, Shull GE, Muallem S, Baum M (2000) Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J. Clin. Invest. 105, 1141-1146.
9. Corman B, Pratz J, Poujeol P (1985) Changes in anatomy, glomerular filtration and solute excretion in old rat kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 248, R282-R287.
10. Davies DF, Shock NW (1950) Age changes in glomerular filtration rate, effective renal plasma flow and tubular excretory capacity in adult males. J. Clin. Invest. 29, 496-507.
11. + flux in proximal tubules through NO release. Am. J. Physiol. Renal Physiol. 280, F239-F243.
12. + exchanger-NHE3 and NHE2. Biochim. Biophys. Acta 1664, 38-44.
13. Edsall JT, Wyman J (1958) Biophysical Chemistry, Vol. I. New York: Academic Press, Inc.
14. Frassetto L, Sebastian A (1996) Age and systemic acid-base equilibrium: analysis of published data. J. Gerontol. A Biol. Sci. Med. Sci. 51, B91-B99.
15. Goyal S, Mentone S, Aronson PS (2005) Immunolocalization of NHE8 in rat kidney. Am. J. Physiol. Renal Physiol. 288, F530-F538.
16. + exchanger isoform NHE8. Am. J. Physiol. Renal Physiol. 284, F467-F473.
17. Hill L, Lateef AM, Engels K, Samsell L, Baylis C (1997) Basal and stimulated nitric oxide in control of kidney function in the aging rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 272, R1747-R1753.
18. + exchanger in rat renal brush border membranes. Can. J. Physiol. Pharmacol. 75, 1226-1231.
19. Jung FF, Kennefick TM, Ingelfinger JB, Vora JP, Anderson S (1995) Downregulation of the intrarenal renin-angiotensin system in the aging rat. J. Am. Soc. Nephrol. 5, 1573-1580.
20. + exchange activity in the aging rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 252, R681-R686.
21. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
22. Lindeman RD (1995) Renal and urinary tract function. In Handbook of Physiology, Section 11: Aging (Masoro EJ ed.). New York: Oxford University Press, pp. 485-503.
23. Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J. Am. Geriatr. Soc. 33, 278-285.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the Folin phenol reagents. J. Biol. Chem. 193, 265-275.
25. MacLaughlin M, Damasco MC, Igarreta P, Amorena C (2001) In vitro and in vivo evaluation of proximal tubular acidification in aging rats. Am. J. Physiol. 280, R1627-R1631.
26. Manning RD, Hu L, Reckelhoff JF (1997) Role of nitric oxide in the arterial pressure and renal adaptations to long-term changes in sodium intake. Am. J. Physiol. Regul. Integr. Comp. Physiol. 272, R1162-R1169.
27. + -ATPase in the kidney. J. Nephrol. 15, S22-S31.
28. Nelson N, Harvey WR (1999) Vacuolar and plasma membrane proton-adenosinetriphosphatases. Physiol. Rev. 79, 361-385.
29. Orlowsky M, Meister A (1965) Isolation of Υ-glutamyl transpeptidase from hog kidney. J. Biol. Chem. 240, 338-347.
30. Papper S (1973) The effects of age in reducing renal function. Geriatrics 28, 83-87.
31. Pecci A, Cozza EN, Devlin M, Gomez-Sanchez CE, Gomez-Sanchez EP (1994) Endothelin-1 stimulation of aldosterona and zona glomerulosa ouabain sensitive sodium/potassium ATPase. J. Steroid Biochem. Mol. Biol. 50, 49-53.
32. + antiporter in rat proximal tubule bicarbonate absorption. J. Clin. Invest. 80, 970-978.
33. Reilly AM, Harris PJ, Williams DA (1995) Biphasic effect of angiotensin II on intracellular sodium concentration in rat proximal tubules. Am. J. Physiol. 269, F374-F380.
34. + exchanger. Nat. Genet. 19, 282-285.
35. Syneok LL (1976) Peculiarities of acid-base reserves in aging. Ukr. Biokhim. Zh. 48, 72-77.
36. + transport by a cGMP-mediated mechanism in the kidney proximal tubule. Am. J. Physiol. Renal Physiol. 272, F242-F248.
37. Wang T, Hropot M, Aronson PS, Giebisch G (2001) Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. Am. J. Physiol. 281, F1117-F1122.
38. Wang T, Yang CL, Abbiati T, Schultheis PJ, Shull GE, Giebisch G, Aronson PS (1999) Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice. Am. J. Physiol. 277, F298-F302.