Effect of different oral doses of isoniazid-rifampicin in rats

Molecular and Cellular Biochemistry

Volumn 289, Issue 1-2, 2006, Pages 39-47

  Rana, Satya V ^a,b   Pal, Ravinder ^a   Vaiphie, Kim ^a   Singh, Kartar ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b NONE   (India)

Author keywords

Hepatotoxicity; Isoniazid; Rifampicin

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ISONIAZID; RIFAMPICIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; HISTOPATHOLOGY; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; RAT; RAT STRAIN;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BODY WEIGHT; ISONIAZID; LIVER; MALE; RATS; RATS, WISTAR; RIFAMPIN;

RATTUS NORVEGICUS;

EID: 33748301950     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9145-3     Document Type: Article

References (23)

1. Sahbazian B, Weis SE: Treatment of active tuberculosis: Challenges and prospects. Clin Chest Med 26: 273-282, 2005
2. Fernandez-Villar A, Sopena B, Fernandez-Villar J, Vazquez-Gallardo R, Ulloa F, Leiro V, Mosteiro M, Pineiro L: The influence of risk factors on the severity of anti-tuberculosis drug-induced hepatotoxicity. Int J Tuberc Lung Dis 8: 1499-1505, 2004
3. Hussawi Z, Kar P, Husain SA: Antituberculosis drug induced hepatitis: Risk factors, prevention and management. Indian J of Exp Biol 41: 1226-1232, 2003
4. Quenelle DC, Staas JK, Winchester GAA, Barrow ELW, Barrow WW: Efficacy of microencapsulated rifampicin in mycobacterium tuberculosis infected Mice. Antimicrob Agent Chemo 43: 1144-1115, 1999
5. Quenelle DC, Winchester GA, Staas JK, Barrlow LW: Treatment of tuberculosis using a combination of sustained released rifampicin loaded microspheres and oral dosing with isoniazid. Ant Agent and Chemo 45: 1637-1644, 2001
6. Skakun NP, Slivka IuI: Effectiveness of tocopherol and anti-hypoxic agents in liver damage caused by antitubercular agents. Probl Tuberk 3: 57-59, 1991
7. Reitman J, Franketl SA: Colorimetric method for the determination of serum glutamic oxaloacetic acid and serum glutamic pyruvic transaminase. Am J Clin Path 28: 56-63, 1957
8. Powell WN: Serum biluribin estimation. Am J Clin Path 14: 55-57, 1944
9. Bergemer MKC: Method of enzymatic analysis. Academic press, New York 40: 783-785, 1963.
10. Brown JS, Wilson WE, Grant LD: Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal Toxicol 17: 355-385, 2005
11. Hardistiy JF, Brix AE: Comparative hepatic toxicity: Pre chronic liver toxicity in rodents. Toxicol Pathol 33: 35-40,2005
12. Frank I, Lahav D, Aroch I: Myocardial necrosis and severe metabolic acidosis associated with isoniazid poisoning in dog. Vet Reco 151: 638-639, 2002
13. Attri S, Rana SV, Vaiphei K, Sodi CP, Katyal R, Goel RC, Nain CK, Singh K: Isoniazid-rifampicin induced oxidative hepatic injury protection by N-acetylcysteine. Human & Exp Toxico 19: 517-522, 2000
14. Kasilo OJ, Nihach CFB, Nahlet M: Isoniazid-International programme on chemical toxicity. Poisons information monograph. Pharmaceutical: 288-291, 1999
15. Cro HJ, Mood BM, Magarey J: Rifampicin IARC Summary and Evaluation: 24-26, 1980
16. Rifandin (Hoechst Marian Roussel) In: PDR Phsycian desk reference. 54th ed 2000 oradell. N J Medical Economics Data: 1379-1382, 2000
17. Ellenhorn MJ, BarCeloux DG: Antiinfective drugs. Medical Toxicology, Diagnosis and Treatment of Human poisioning. Amsterdam Elsevier: 29, 1988
18. Mandel GL, Sande MA: Antimicrobial agents. Goodman and Gillman. The pharmacologic basis of therapeutics. 7th ed. Macmillian Publish Co: 61-64, 1985
19. Mitchell JR, Zimmerman HJ, Ishak KG: Thorgierson, U.P. Isoniazid liver injury: Clinical spectrum pathology and probable pathogenesis. Ann Intern Med 84: 181-192, 1976
20. Karthikryan S: Hepatotoxicity of isoniazid: A study in the activity of marker enzymes of liver toxicity in serum and liver of rabbits. Ind J Pharmaco 36:247-249, 1995
21. Snodgross W, Potter W, Timbrell JA, Jollow DI: Possible mechanism of isoniazid related hepatic injury. Clin Res 22: 323-326, 1974
22. Heiserg GB, Hughes WC, Long CM: Rozmaiorkherh. The guinea pigs as model for isoniazid induced reactions. LabAnimal Sci 30: 42-50, 1980
23. Tasduq SA, Kaiser P, Gupta PK, Kapahi BK: Protective effect of 50% hydroalcoholic fruit extract of Emblica officinalis against antituberculosis drugs induced liver toxicity. Phytother Res 19: 193-197, 2005