Myocardial necrosis and severe metabolic acidosis associated with isoniazid poisoning in a dog

Veterinary Record

Volumn 151, Issue 21, 2002, Pages 638-639

  Frank, I ^a   Lahav, D ^a   Aroch, I ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CALCIUM ION; CYANOCOBALAMIN; DIAZEPAM; FUROSEMIDE; ISOFLURANE; ISONIAZID; MAGNESIUM ION; OXYGEN; PENTOBARBITAL; POTASSIUM ION; RINGER LACTATE SOLUTION; SODIUM ION; TUBERCULOSTATIC AGENT;

ANIMAL TISSUE; ARTICLE; BLADDER BLEEDING; CONVULSION; DISEASE SEVERITY; DOG; DRUG INTOXICATION; DRUG OVERDOSE; FEMALE; HEART MUSCLE NECROSIS; HEART RIGHT VENTRICLE; HISTOPATHOLOGY; LUNG EDEMA; METABOLIC ACIDOSIS; NONHUMAN; PATHOGENESIS; THROMBOCYTOPENIA; ACIDOSIS; ANIMAL; CASE REPORT; CHEMICALLY INDUCED DISORDER; DOG DISEASE; HEART MUSCLE; LIVER; NECROSIS; PATHOLOGY;

ANIMALIA; CANIS FAMILIARIS;

ACIDOSIS; ANIMALS; ANTITUBERCULAR AGENTS; DOG DISEASES; DOGS; FEMALE; ISONIAZID; LIVER; MYOCARDIUM; NECROSIS;

EID: 0037164441     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.151.21.638     Document Type: Article

References (9)

1. BOOTHE, D. M. (2001) Treatment of bacterial infections. In Small Animal Clinical Pharmacology and Therapeutics. Philadelphia, W. B. Saunders. pp 210-211
2. CHIN, L., SIEVERS, M. L. & LAIRD, H. E. (1978) Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs. Toxicology and Applied Pharmacology 45, 713-722
3. CHIN, L. SIEVERS, M. L. & HERRIER, R. N. (1979) Convulsions as the aetiology of lactic acidosis in acute isoniazid toxicity in dogs. Toxicology and Applied Pharmacology 49, 377-384
4. DOHERTY, T. (1982) Isoniazid poisoning in a dog. Veterinary Record 111, 460
5. GERALD, L. M. & WILLIAM, A. P. Jr (1996) Antimicrobial agents. In The Pharmacological Basis of Therapeutics. 9th edn. Eds L. S. Goodman, A. Gilman. New York, Macmillan. pp 1155-1159
6. GREENE, C. E. (2000) Bacterial diseases. In Textbook of Veterinary Internal Medicine. 5th edn. Eds S. J. Ettinger, E. C. Feldman. Philadelphia, W. B. Saunders. pp 393-394
7. GURNANI, A., CHAWLA, R. & KUNDRA, P. (1992) Acute isoniazid poisoning. Anaesthesia 47, 781-783
8. ROBIN, B. & BURKE, J. C. (1953) Further observation on the pharmacology of isoniazid. American Review of Tuberculosis 67, 644-651
9. VILLAR, D., KNIGHT, M. K., HOLDING, J., BARRET, G. H. & BUCK, W. B. (1995) Treatment of acute isoniazid overdose in dogs. Veterinary and Human Toxicology 37, 473-477