Some pregnancy-related effects of artemether in laboratory animals

Pharmacology

Volumn 77, Issue 4, 2006, Pages 166-170

  Ejiofor, Janet I ^a   Kwanashie, Helen O ^a   Anuka, Joseph A ^a  

^a AHMADU BELLO UNIVERSITY   (Nigeria)

Author keywords

Artemether; Birth weight; Conception; Growth profile; Guinea pig; Isolated uterine smooth muscles; Litter size; Oestrous cycle; Pregnancy; Rat

Indexed keywords

ARTEMETHER; OXYTOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; CHILDBIRTH; CONCEPTION; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; ESTRUS CYCLE; EXPERIMENTAL ANIMAL; FEMALE; GESTATION PERIOD; GROWTH RATE; GUINEA PIG; LITTER SIZE; MALE; MYOMETRIUM; NONHUMAN; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; RAT; UTERUS CONTRACTION;

ANIMALS; ANIMALS, LABORATORY; ANTIMALARIALS; ARTEMISININS; BIRTH WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EMBRYONIC DEVELOPMENT; ESTROUS CYCLE; FEMALE; FERTILIZATION; GUINEA PIGS; INJECTIONS, INTRAPERITONEAL; LITTER SIZE; MALE; MYOMETRIUM; OXYTOCIN; PREGNANCY; RATS; RATS, WISTAR; UTERINE CONTRACTION;

EID: 33748300695     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094521     Document Type: Article

References (20)

1. Pe TM, Tin S: A controlled clinical trial of Artemether (qinqhaosu derivative) versus quinine in complicated and severe falciparum malaria. Trans R Soc trop Med Hyg 1987;81:4-6.
2. Basco LK, Le Bras J: In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum. Am J Trop Med Hyg 1993;49:3-4.
3. Wernsdorfer WH: Epidemiology of drug resistance in malaria. Acta Trop 1994;56:2-3.
4. de-Vries PJ, Dien TK: Clinical Pharmacology and Therapeutic Potential of Artemisinin and its derivatives in treatment of malaria. Drugs 1996;52:6-7.
5. Kamchonwongpaisan S, Meshnick SK: The mode of action of the antimalarial artemisinin and its derivatives. General Pharmacology 1996;27:4-5.
6. Pharmanews: Experts fault malaria treatment policy. June 2005;27:9-12.
7. Salako L: Artemisinin and its derivatives: the regulatory and policy implications for African countries. Trop Med 1998;58(3 suppl):82-84.
8. Levy G: Pharmacokinetics of foetal and neonatal exposure to drugs. Obstet Gynec 1981; 58(5 suppl):9-16.
9. Deen JL, Von-Seidlein L, Pinder M, Walraven GE, Greenwood BM: The safety of the combination of artesunate and pyrimethamine-sulfadoxine given during pregnancy. Trans R Soc trop Med Hyg 2001;95:424-428.
10. Bounyasong S: Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women. J Med Assoc Thailand 2001;84:1289-1299.
11. McGready R, Cho T, Keo NK, Thwai KL, Villegas L, Looareesuwan S, White NJ, Nosten F: Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum. J Clin Infect Dis 2001;33:2009-2016.
12. UNDP/World Bank/WHO: Introduction to the OECD principles of GLP. Special Programme for Research and Training in Tropical Diseases (TDR) - Good Laboratory Practice Training Manual for the Trainee, 2001, pp 3-19.
13. Allen E, Doisy EA: An Ovarian hormone. Preliminary report on its localization, extraction and partial purification and action in test animals. J Am Med Assoc 1923;81:819-821.
14. Dale H, Laidlaw JL: A method for standardizing pituitary (infundibular) extracts. J Pharmacol Exp Ther 1912;4:73-95.
15. Holton P: A modification of the method of Dale and Laidlaw for the standardization of posterior pituitary extract. Br J Pharmacol 1948;3:328-334.
16. Krinke GJ: The Laboratory Rat: The Handbook of Experimental Animals. New York, Academic Press, 2000, pp 152-156.
17. Weihe WH: The Laboratory Rat; in Poole BT, Robinson R (eds): The UFAW Handbook on the Care and Management of Laboratory Animals, ed 6. Oxford, Blackwell, 1987, pp 275-280.
18. Wambebe C, Kwanashie HO, Ikediobi CO, Osuide GO: Effects of cimetidine on female fertility and pregnancy outcome in mouse and rat. W Afr J Pharmac Drug Res 1990;9(suppl):43-47.
19. Clayton SG, Fraser D, Lewis TLT: Obstetrics by Ten Teachers, ed 12. London, Edward Arnold, 1976, pp 314-331.
20. Kwanashie HO, Ejiofor JI, Olurishe T, Saliu VW: Pharmacological evidence for cautious use of quinine in late pregnancy and its frequent failure as an abortifacient. 3rd International Conference of NAWACS, 2002, pp 40-41.