Uptake of dexamethasone incorporated into liposomes by macrophages and foam cells and its inhibitory effect on cellular cholesterol ester accumulation

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 9, 2006, Pages 1219-1225

  Chono, Sumio ^a   Morimoto, Kazuhiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER; DEXAMETHASONE; DICETYL PHOSPHATE; LIPOSOME; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ATHEROSCLEROSIS; CELL LEVEL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG UPTAKE; EGG YOLK; FOAM CELL; HYDRATION; IN VITRO STUDY; LIPID STORAGE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; SUSPENSION; ZETA POTENTIAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; CELLS, CULTURED; CHOLESTEROL ESTERS; DEXAMETHASONE; DRUG COMPOUNDING; FOAM CELLS; LIPID METABOLISM; LIPIDS; LIPOPROTEINS, LDL; LIPOSOMES; MACROPHAGES; MICE; PARTICLE SIZE; PHARMACOKINETICS;

EID: 33748292896     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.9.0008     Document Type: Article

References (24)

1. Asai, K., Funai, C., Hayashi, T., Yamada, K., Naito, M., Kuzuya, M., Yamada, K., Yoshimine, N., Kuzuya, F. (1993) Dexamethasone-induces suppression of aortic atherosclerosis in cholesterol-fed rabbits. Arterioscler. Thromb. 13: 892-899
2. Bradford, M. M. (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
3. Derksen, J. T., Morselt, H. W., Scherphof, G. L. (1987) Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages. Biochim. Biophys. Acta 931: 33-40
4. DiMatteo, M., Reasor, M. J. (1997) Modulation of silica-induced pulmonary toxicity by dexamethasone-containing liposomes. Toxicol. Appl. Pharmacol. 142: 411-421
5. Harashima, H., Sakata, K., Funato, K., Kiwada, H. (1994) Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. Pharmaceut. Res. 11: 402-406
6. Harashima, H., Hirai, N., Kiwada, H. (1995) Kinetic modelling of liposome degradation in peritoneal macrophages. Biopharm. Drug Dispos. 16:113-123
7. Hatch, F., Less, R. S. (1968) Practical methods for plasma lipoprotein analysis. Adv. Lipid Res. 6: 2-63
8. Heath, T. D., Lopez, N. G., Papahadjopoulos, D. (1985) The effects of liposome size and surface charge on liposome-mediated delivery of methotrexate-gamma-aspartate to cells in vitro. Biochim. Biophys. Acta. 820: 74-84
9. Hodis, H. N., Amartey, J. K., Crawford, D. W., Wickham, E., Sharma, R. C., Blankenhorn, D. H. (1991) Relationship of arterial wall uptake of radiolabelled liposomes to the presence of monocyte/macrophage cells in the hypertensive and atherosclerotic arterial wall. Atherosclerosis 87: 109-117
10. Huong, T. M., Harashima, H., Kiwada, H. (1998) Complement dependent and independent liposome uptake by peritoneal macrophages: cholesterol content dependency. Biol. Pharm. Bull. 21: 969-973
11. Makheja, A. N., Bloom, S., Muesing, R., Simon, T., Bailey, J. M. (1989) Anti-inflammatory drugs in experimental atherosclerosis. 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate. Atherosclerosis 76: 155-161
12. Naito, M., Yasue, M., Asai, K., Yamada, K., Hayashi, T., Kuzuya, M., Funaki, C., Yoshimine, N., Kuzuya, F. (1992) Effects of dexamethasone on experimental atherosclerosis in cholesterol-fed rabbits. Arterioscler. Thromb. 38: 255-264
13. Pool, G. L., French, M. E., Edwards, R. A., Huang, L., Lumb, R. H. (1982) Use of radiolabelled hexadecyl cholesteryl ether as a liposome marker. Lipids 17: 445-452
14. Rahman, Y. E., Cemy, E. A., Patel, K. R., Lau, E. H., Wright, B. J. (1982) Differential uptake of liposomes varying in size and lipid composition by parenchymal and kupffer cells of mouse liver. Life Sci. 31: 2061-2071
15. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809
16. Ryu, B. H., Mao, F. W., Lou, P., Gutman, R. L., Greenspan, P. (1995) Cholesteryl ester accumulation in macrophages treated with oxidized low density lipoprotein. Biosci. Biotech. Biochem. 59: 1619-1622
17. Tauchi, Y., Takase, M., Zushida, I., Chono, S., Sato, J., Ito, K., Morimoto, K. (1999) Preparation of a complex of dexamethasone palmitate-low density lipoprotein and its effect on foam cell formation of murine peritoneal macrophages. J. Pharm. Sci. 88: 709-714
18. Tauchi, Y., Zushida, L., Yokota, M., Chono, S., Sato, J., Ito, K., Morimoto, K. (2000) Inhibitory effect of dexamethasone palmitate-low density lipoprotein complex on low density lipoprotein-induced macrophage foam cell formation. Biol. Pharm. Bull. 23: 466-471
19. Tauchi, Y., Zushida, L., Chono, S., Sato, J., Ito, K., Morimoto, K. (2001) Effect of dexamethasone palmitate-low density lipoprotein complex on cholesterol ester accumulation in aorta of atherogenic model mice. Biol. Pharm. Bull. 24: 925-929
20. Tauchi, Y., Chono, S., Morimoto, K. (2003) Cellular uptake of a dexamethasone palmitate-low density lipoprotein complex by macrophages and foam cells. J. Drug. Target. 11: 163-168
21. Tedgui, A., Bernard, C. (1994) Cytokines, immuno-inflammatory response and atherosclerosis. Eur. Cytokine Network 5: 263-270
22. Van Put, D. J. M., Van Hove, C. E., De Meyer, G. R. Y., Wuyts, F., Herman, A. G., Bull, H. (1995) Dexamethasone influences intimai thickening and vascular reactivity in the rabbit collared carotid artery. Eur. J. Pharmacol. 294: 753-761
23. Witztum, J. L., Steinberg, D. (1991) Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88: 1785-1792
24. Yla-Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S., Witztum, J. L., Steinberg, D. (1989) Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest. 84: 1086-1095