Remission status defined by immunofixation vs. electrophoresis after autologous transplantation has a major impact on the outcome of multiple myeloma patients

British Journal of Haematology

Volumn 109, Issue 2, 2000, Pages 438-446

  Lahuerta, Juan Jose ^a   Martinez Lopez, Joaquin ^b   De la Serna, Javier ^b   Bladé, Joan ^b   Grande, Carlos ^b   Alegre, Adrián ^b   Vazquez, Lourdes ^b   García Laraña, José ^b   Sureda, Ana ^b   De la Rubia, Javier ^b   Conde, Eulogio ^b   Martinez, Raeael ^b   Perez Equiza, Katy ^b   Moraleda, José M ^b   León, Angel ^b   Besalduch, Juan ^b   Cabrera, Rafael ^b   Miguel, Jose D Gonzalez San ^b   Morales, Alfonso ^b   García Ruíz, Juan C ^b   Diaz Mediavilla, Joaquín ^b   San Miguel, Jesús ^b   more..

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b NONE

Author keywords

Autotransplant; Electrophoresis; Immunofixation; Multiple myeloma; Response criteria

Indexed keywords

BUSULFAN; MELPHALAN;

ADULT; AGED; ARTICLE; AUTOTRANSPLANTATION; CANCER REGRESSION; CANCER SURVIVAL; ELECTROPHORESIS; FEMALE; HUMAN; MALE; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROGNOSIS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

ELECTROPHORESIS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; PARAPROTEINS; PRECIPITIN TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 0034039018     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02012.x     Document Type: Article

References (34)

1. Alexanian, R., Haut, A., Khan, A., Lane, M., McKelvey, E., Migliore, P.J., Stuckey, W.J.J. & Wilson, H.E. (1969) Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. Journal of the American Medical Association, 208, 1680-1685.
2. Alexanian, R., Bonnet, J., Gehan, E., Haut, A., Hewlett, J., Lane, M., Monto, R. & Wilson, H. (1972) Combination chemotherapy for multiple myeloma. Cancer, 30, 382-389.
3. Anderson, K.C., Andersen, J., Soiffer, R., Freedman, A.S., Rabinowe, S.N., Robertson, M.J., Spector, N., Blake, K., Murray, C. & Freeman, A. (1993) Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma. Blood, 82, 2568-2576.
4. Attal, M., Harousseau, J.L., Stoppa, A.M., Sotto, J.J., Fuzibet, J.G., Rossi, J.F., Casassus, P., Maisonneuve, H., Facon, T., Ifrah, N., Payen, C. & Bataille, R. (1996) A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. New England Journal of Medicine, 335, 91-97.
5. Attal, M., Payen, C., Facon, T., Michaux, J.L., Guilhot, F., Moconduit, M., Fuzibet, D.C., Caillot, V., Dorvaux, J.L., Harousseau, J.Y., Cahn, B., Grobois, A.M., Stoppa, N., Ifrah, J.J., Sotto, B., Pignon, R. & Bataille, R. (1998) Single versus double transplant in myeloma: a randomized trial of the 'Intergroupe Français du Myélome'. Bone Marrow Transplantation, 22, 718a.
6. Ballester, O.F., Tummala, R., Janssen, W.E., Fields, K.K., Hiemenz, J.W., Goldstein, S.C., Perkins, J.B., Sullivan, D.M., Rosen, R., Sackstein, R., Zorsky, P., Saez, R. & Elfenbein, G.J. (1997) High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency. Bone Marrow Transplantation, 20, 653-656.
7. Barlogie, B., Jagannath, S., Vesole, D.H., Naucke, S., Cheson, B., Mattox, S., Bracy, D., Salmon, S., Jacobson, J., Crowley, J. & Tricot, G. (1997) Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma. Blood 89, 789-793.
8. Barlogie, B., Jagannath, S., Desikan, K.R., Mattox, S., Vesole, D., Siegel, D., Tricot, G., Munshi, N., Fassas, A., Singhal, S., Mehta, J., Anaissie, E., Dhodapkar, D., Naucke, S., Cromer, J., Sawyer, J., Epstein, J., Spoon, D., Ayers, D., Cheson, B. & Crowley, J. (1999) Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood, 93, 55-65.
9. Björkstrand, B., Ljungman, P., Bird, J.M., Samson, D. & Gahrton, G. (1995) Double high-dose chemoradiotherapy with autologous stem cell transplantation can induce molecular remissions in multiple myeloma. Bone Marrow Transplantation, 15, 367-371.
10. Björkstrand, B., Svensson, H., Ljungman, P., Apperley, J., Goldschmidt, H., Remes, P., Alegre, A., Marcus, R., Carlson, P., Coser, P., Sureda, A., Barbui, T. Goldstone, A.H., Bladé, J., Volin, L., Boogaerts, M., Lenhoff, S., Majolino, I., de Samson, D., Laurenzi, A., Caballero, D. & Gahrton, G. (1997) 2522 autotransplants in multiple myeloma - a registry study from the European group for Blood and Marrow Transplantation (EBMT). Blood, 90, 419a.
11. Björkstrand, B., Svensson, H., Goldschmidt, H., Ljungman, P., Apperley, J., Remes, K., Marcus, R., Barbui, T., Alegre, A., Majolino, I., Carlson, K., Boogaerts, M., Coser, P., Iriondo, A., Sureda, A., de Lenhoff, S., Laurenzi, A., Bladé, J., Ferrant, A., Goldstone, A.H. & Gahrton, G. (1999) Autologous stem cell transplantation in multiple myeloma - the 1999 EBMT registry update. Bone Marrow Transplantation, 22, 718a.
12. Blade, J., Lopez-Guillermo, A., Bosch, F., Cervantes, F., Reverter, J.C., Montserrat, E. & Rozman, C. (1994) Impact of response to treatment on survival in multiple myeloma: results in a series of 243 patients. British Journal of Haematology, 88, 117-121.
13. Blade, J., Samson, D., Reece, D., Apperley, J., Bjorkstrand, B., Gahrton, G., Gertz, M., Giralt, S., Jagannath, S. & Vesole, D. (1998) Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. British Journal of Haematology, 102, 1115-1123.
14. Brisco, J., Hughes, E., Neoh, S.H., Sykes, P.J., Bradstock, K., Enno, A., Szer, J., McCaul, K. & Morley, A.A. (1996) Relationship between minimal residual disease and outcome in adult acute lymphoblastic leukemia. Blood, 87, 5251-5256.
15. Chronic Leukemia and Myeloma Task Force. (1968) Proposed guidelines for protocol studies. II. Plasma cell myeloma. Cancer Chemotherapy Reports, 1, 17-39.
16. Chronic Leukemia and Myeloma Task Force of the National Cancer Institute. (1973) Proposed guidelines for protocol studies. II. Plasma cell myeloma. Cancer Chemotherapy Reports, 4, 141-173.
17. Cunningham, D., Paz-Ares, L., Milan, S., Powles, R., Nicolson, M., Hickish, T., Selby, P., Treleavan, J., Viner, C. & Malpas, J. (1994) High-dose melphalan and autologous bone marrow transplantation as consolidation in previously untreated myeloma. Journal of Clinical Oncology, 12, 759-763.
18. Dimopoulos, M.A., Alexanian, R., Przepiorka, D., Hester, J., Andersson, B., Giralt, S., Mehra, R., van Besien, K., Delasalle, K.B. & Reading, C. (1993) Thiotepa, busulfan, and cyclophosphamide: a new preparative regimen for autologous marrow or blood stem cell transplantation in high-risk multiple myeloma. Blood, 82, 2324-2328.
19. Duc, J., Morel, B., Peitrequin, R. & Frei, P.C. (1988) Identification of monoclonal gammopathies: a comparison of immunofixation, immunoelectrophoresis and measurements of kappa and lambda immunoglobulin levels. Journal of Clinical and Laboratory Immunology, 26, 141-146.
20. Fermand, J.P., Ravaud, P., Chevret, S., Divine, M., Leblond, V., Belanger, C., Macro, M., Pertuiset, E., Dreyfus, F., Mariette, X., Boccacio, C. & Brouet, J.C. (1998) High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized clinical trial. Blood, 92, 3131-3136.
21. Gore, M.E., Selby, P.J., Viner, C., Clark, P.I., Meldrum, M., Millar, B., Bell, J., Maitland, J.A., Milan, S. & Judson, I.R. (1989) Intensive treatment of multiple myeloma and criteria for complete remission. Lancet, ii, 879-882.
22. Joshua, D.E., Penny, R., Matthews, J.P., Laidlaw, C.R., Gibson, J., Bradstock, K., Wolf, M. & Goldstein, D. (1997) Australian Leukaemia Study Group myeloma II: a randomized trial of intensive combination chemotherapy with or without interferon in patients with myeloma. British Journal of Haematology, 97, 38-45.
23. Keren, D.F. (1999) Procedures for the evaluation of monoclonal immunoglobulins. Archives of Pathological Laboratory and Medicine, 123, 126-132.
24. Keren, D.F., Warren, J.S. & Lowe, J.B. (1988) Strategy to diagnose monoclonal gammopathies in serum: high-resolution electrophoresis, immunofixation, and kappa/lambda quantification. Clinical Chemistry, 34, 2196-2201.
25. Kyle, R.A., Leong, T., Oken, M.M., Kay, N.E., Van Ness, B. & Greipp, P.R. (1998) The effect of complete response on survival in an ECOG phase III trial for multiple myeloma. Blood, 90, 1310a.
26. MacLennan, L.C., Chapman, C., Dunn, J. & Kelly, K. (1992) Combined chemotherapy with ABCM versus melphalan for treatment of myelomatosis. Lancet, 339, 200-205.
27. Marmont, F., Levis, A., Falda, M. & Resegotti, L. (1991) Lack of correlation between objective response and death rate in multiple myeloma patients treated with oral melphalan and prednisone. Annals of Oncology, 2, 191-195.
28. McElwain, T.J. & Powles, R.L. (1983) High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Lancet, ii, 822-824.
29. San Miguel, J.F., Martinen, A., Macedo, A., Vidriales, M.B., Lopez-Berges, C., Gonzalez, M., Caballero, D., Garcia-Marcos, M.A., Ramos, F., Fernandez-Calvo, J., Calmuntia, M.J., Diaz-Mediavilla, J. & Orfao, A. (1997) Immunophenotyping investigation of minimal residual disease is a useful approach for predicting relapse in acute myeloid leukemia patients. Blood, 90, 2465-2470.
30. San Miguel, J.F., Bladé, J. & García-Sanz, R. (1999) Treatment of multiple myeloma. Haematologica, 84, 36-58.
31. Selby, P.J., McElwain, T.J., Nandi, A.C., Perren, T.J., Powles, R.L., Tillyer, C.R., Osborne, R.J., Slevin, M.L. & Malpas, J.S. (1987) Multiple myeloma treated with high dose intravenous melphalan. British Journal of Haematology, 66, 55-62.
32. Sinclair, D., Sheehan, T., Parrott, D.M. & Stott, D.I. (1986) The incidence of monoclonal gammopathy in a population over 45 years old determined by isoelectric focusing. British Journal of Haematology, 64, 745-750.
33. Vesole, D.H., Tricot, G., Jagannath, S., Desikan, K.R., Siegel, D., Bracy, D., Miller, L., Cheson, B., Crowley, J. & Barlogie, B. (1996) Autotransplants in multiple myeloma: what have we learned? Blood, 88, 838-847.
34. Whicher, J.T. (1983) Immunofixation on cellulose acetate is more efficient than immunoelectrophoresis for detection of paraproteins. Clinical Chemistry, 29, 402-403.