Role of hormones in the pathophysiology of pelvic floor disorders in women

Current Opinion in Obstetrics and Gynecology

Volumn 18, Issue 5, 2006, Pages 525-527

  Bhatia, Narender N ^a,b   Ho, Mat H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Bld D3 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; FLUTAMIDE; MESSENGER RNA; PROTEIN; S6 KINASE; TESTOSTERONE;

ADIPOCYTE; ADIPOGENESIS; CELL DIFFERENTIATION; CELL DIVISION; CELL STRAIN 3T3; DNA BINDING; EDITORIAL; HUMAN; IMMUNOCYTOCHEMISTRY; LEVATOR ANI MUSCLE; LIGAND BINDING; MUSCLE DEVELOPMENT; MUSCLE HYPERTROPHY; NONHUMAN; PATHOPHYSIOLOGY; PELVIC ORGAN PROLAPSE; PELVIS FLOOR; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT STRAIN; SATELLITE CELL;

FEMALE; GONADAL HORMONES; HUMANS; MUSCULAR DISEASES; PELVIC FLOOR;

EID: 33748273883     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gco.0000242955.40491.c5     Document Type: Editorial

References (5)

1. Hendrix SL, Cochrane BB, Nygaard IE, et al. Effects of estrogen with and without progestin on urinary incontinence. JAMA 2005; 293:935-948.
2. Ho MH, Bhatia NN, Bhasin S. Anabolic effects of androgens on muscles of female pelvic floor and lower urinary tract. Curr Opin Obstet Gynecol 2004; 16:405-409.
3. Xu T, Shen Y, Pink H, et al. Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats. J Steroid Biochem Mol Biol 2004; 92:447-454.
4. Singh R, Artaza JN, Taylor WE, et al. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 2003; 144:5081-5088.
5. Singh R, Artaza JN, Taylor WE, et al. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 2006; 147:141-154.