Regulation of protein phosphatase 1γ activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism

Journal of Cellular Physiology

Volumn 209, Issue 1, 2006, Pages 211-218

  Comerford, Kathrina M ^a   Leonard, Martin O ^a   Cummins, Eoin P ^a   Fitzgerald, Kathleen T ^a   Beullens, Monique ^a   Bollen, Mathieu ^b   Taylor, Cormac T ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENZYME INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1GAMMA; PROTEIN NIPP1; UNCLASSIFIED DRUG;

ADAPTATION; ARTICLE; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; ENERGY CONSUMPTION; ENZYME REGULATION; EUKARYOTIC CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELL HYPOXIA; CREB-BINDING PROTEIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDORIBONUCLEASES; ENZYME ACTIVATION; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EUKARYOTA;

EID: 33748249472     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20726     Document Type: Article

References (33)

1. Alessi D, Macdougall LK, Sola MM, Ikebe M, Cohen P. 1992. The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1. Eur J Biochem 210:1023-1035.
2. Beullens M, Bollen M. 2002. The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J Biol Chem 277:19855-19860.
3. Beullens M, Van Eynde A, Bollen M, Stalmans W. 1993. Inactivation of nuclear inhibitory polypeptides of protein phosphatase-1 (NIPP-1) by protein kinase A. J Biol Chem 268:13172-13177.
4. Beullens M, Vulsteke V, Van Eynde A, Jagiello I, Stalmans W, Bollen M. 2000. The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding. Biochem J 352:651-658.
5. Bollen M. 2001. Combinatorial control of protein phosphatase-1. Trends Biochem Sci 26:426-431.
6. Bollen M, Stalmans W. 1992. The structure, role, and regulation of type 1 protein phosphatases. Crit Rev Biochem Mol Biol 27:227-281.
7. Brautigan DL, Pinault FM. 1991. Activation of membrane protein-tyrosine phosphatase involving cAMP- and Ca2+/phospholipid-dependent protein kinases. Proc Natl Acad Sci USA 88:6696-6700.
8. Carling D. 2004. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 29:18-24.
9. Ceulemans H, Bollen B. 2004. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev 84:1-39.
10. Cohen PT. 1988. Two isoforms of protein phosphatase 1 may be produced from the same gene. FEBS Lett 232:17-23.
11. Cohen P. 1989. The structure and regulation of protein phosphatases. Annu Rev Biochem 58:453-508.
12. Cohen PT. 2002. Protein phosphatase 1-targeted in many directions. J Cell Sci 115:241-256.
13. Dombradi V, Axton JM, Brewis ND, da Cruz e Silva EF, Alphey L, Cohen PT. 1990. Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1. Eur J Biochem 194(3):739-745.
14. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. 2003. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2:28.
15. Huang FL, Glinsmann WH. 1976. Separation and characterization of two phosphorylase phosphatase inhibitors from rabbit skeletal muscle. Eur J Biochem 70:419-426.
16. Jagiello I, Van Eynde A, Vulsteke V, Beullens M, Boudrez A, Keppens S, Stalmans W, Bollen M. 2000. Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. J Cell Sci 113:3761-3768.
17. Jin Q, Van Eynde A, Beullens M, Roy N, Thiel G, Stalmans W, Bollen M. 2003. The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. J Biol Chem 278:30677-30685.
18. Lesage B, Beullens M, Nuytten M, Van Eynde A, Keppens S, Himpens B, Bollen M. 2004. Interactor-mediated nuclear translocation and retention of protein phosphatase-1. J Biol Chem 279:55978-55984.
19. Mayr B, Montminy M. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609.
20. Meng X, Ao L, Shames BD, Harken AH. 2001. Inhibition of cyclic-3′,5′-nucleotide phosphodiesterase abrogates the synergism of hypoxia with lipopolysaccharide in the induction of macrophage TNF-alpha production. J Surg Res 101:210-215.
21. Ogawa S, Koga S, Kuwabara K, Brett J, Morrow B, Morris SA, Bilezikian JP, Silverstein SC, Stern D. 1992. Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels. Am J Physiol 262:C546-C554
22. Rehfuss RP, Walton KM, Loriaux MM, Goodman RH. 1991. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J Biol Chem 266:18431-18434.
23. Samari HR, Moller MT, Holden L, Asmyhr T, Seglen PO. 2005. Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. Biochem J 386:237-244.
24. Schillace RV, Scott JD. 1999. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr Biol 9:321-324.
25. Taylor CT, Dzus AL, Colgan SP. 1998. Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor alpha. Gastroenterology 114:657-668.
26. Taylor CT, Fueki N, Agah A, Herschberg RM, Colgan SP. 1999. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. J Biol Chem 274:19447-19454.
27. Taylor CT, Furuta GT, Synnestvedt K, Colgan SP. 2000. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci USA 97:12091-12096.
28. Udho E, Tedesco VC, Zygmunt A, Krucher NA. 2002. PNUTS (phosphatase nuclear targeting subunit) inhibits retinoblastoma-directed PP1 activity. Biochem Biophys Res Commun 297:463-467.
29. Van Eynde A, Beullens M, Stallmans W, Bollen M. 1994. Full activation of a nuclear species of protein phosphatase-1 by phosphorylation with protein kinase A and casein kinase-2. Biochem J 297:447-449.
30. Van Eynde A, Wera S, Beullens M, Torrekens S, Van Leuven F, Stalmans W, Bollen M. 1995. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. J Biol Chem 272:28068-28974.
31. Vulsteke V, Beullens M, Waelkens E, Stalmans W, Bollen M. 1997. Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1). J Biol Chem 272:32972-32978.
32. Vulsteke V, Beullens M, Boudrez A, Keppens S, Van Eynde A, Rider MH, Stalmans W, Bollen M. 2004. Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem 279:8642-8647.
33. Zund G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE, Colgan SP. 1996. Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci USA 93:7075-7080.