Bax and Bak are the critical complementary effectors of colorectal cancer cell apoptosis by chemopreventive resveratrol

Anti-Cancer Drugs

Volumn 17, Issue 4, 2006, Pages 471-478

  Pöhland, Thorsten ^a   Wagner, Sascha ^a   Mahyar Roemer, Mojgan ^a   Roemer, Klaus ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Apoptosis; Bak; Bax; Chemoprevention; Colorectal carcinogenesis; Polyphenols

Indexed keywords

DEATH RECEPTOR; LIGAND; PROTEIN BAK; PROTEIN BAX; RESVERATROL;

APOPTOSIS; ARTICLE; CANCER CELL; CHEMOPROPHYLAXIS; COLORECTAL CANCER; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG SENSITIZATION; HUMAN; HUMAN CELL; KNOCKOUT GENE; MITOCHONDRION; PRIORITY JOURNAL; RNA INTERFERENCE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; SIGNAL TRANSDUCTION; STILBENES;

EID: 33748156630     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000203387.29916.8e     Document Type: Article

References (31)

1. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000; 290:989-992.
2. Roemer K, Mahyar-Roemer M, Kohler H. The basis for the chemopreventive action of resveratrol. Drugs Today 2002; 38:571-580.
3. Bhat KPL, Kosmeder 2nd JW, Pezzuto JM. Biological effects of resveratrol. Antioxid Redox Signal 2001; 3:1041-1064.
4. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17:1975-1985.
5. Gautam SC, Xu YX, Dumaguin M, Janakiraman N, Chapman RA. Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant 2000; 25:639-645.
6. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004; 305:626-629.
7. Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 1998; 92:996-1002.
8. Delmas D, Rebe C, Micheau O, Athias A, Gambert P, Grazide S, et al. Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene 2004; 23:8979-8986.
9. Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, et al. Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts. Leukemia 2001; 15:1735-1742.
10. Mahyar-Roemer M, Kohler H, Roemer K. Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells. BMC Cancer 2002; 2:27.
11. Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, et al. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 2001; 15:1613-1615.
12. Huang C, Ma WY, Goranson A, Dong Z. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 1999; 20:237-242.
13. Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 2002; 8:893-903.
14. Holmes-McNary M, Baldwin Jr AS. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 2000; 60:3477-3483.
15. Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 2000; 164:6509-6519.
16. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-730.
17. Mahyar-Roemer M, Fritzsche C, Wagner S, Laue M, Roemer K. Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells. Oncogene 2004; 23:6226-6236.
18. Mahyar-Roemer M, Katsen A, Mestres P, Roemer K. Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. Int J Cancer 2001; 94:615-622.
19. Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 2004; 6:443-450.
20. 2 arrest after DNA damage. Science 1998; 282:1497-1501.
21. Wagner S, Roemer K. Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. Biochem Pharmacol 2005; 69:1059-1067.
22. Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104:263-269.
23. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 2000; 14:2060-2071.
24. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000; 275:16202-16212.
25. Burns TF, El-Deiry WS. Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. J Biol Chem 2001; 276:37879-37886.
26. Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2000; 60:6259-6265.
27. Fulda S, Debatin KM. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res 2004; 64:337-346.
28. Wang S, El-Deiry WS. Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. Proc Natl Acad Sci USA 2003; 100:15095-15100.
29. 2. Cancer Res 1999; 59:2596-2601.
30. CIP expression. Carcinogenesis 2000; 21:1619-1622.
31. Schneider Y, Duranton B, Gosse F, Schleiffer R, Seiler N, Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer 2001; 39:102-107.