RNA interference as potential therapy - Not so fast

New England Journal of Medicine

Volumn 355, Issue 9, 2006, Pages 953-954

  Marsden, Philip A ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MICRORNA; MESSENGER RNA; SMALL INTERFERING RNA;

EXPERIMENTAL MODEL; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENE THERAPY; HUMAN; MEDICAL PRACTICE; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; RNA TRANSLATION; SHORT SURVEY; ANIMAL; ARTICLE; GENETIC TRANSCRIPTION; METABOLISM; MOUSE;

ANIMALS; MICE; MICRORNAS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC;

EID: 33748144763     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr063864     Document Type: Short Survey

References (5)

1. Ribonucleic acid (RNA) - a biomolecule of many functions. Press release of the Royal Swedish Academy of Sciences, Stockholm, October 12, 1989.
2. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
3. Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006;441:537-41.
4. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006;20:515-24.
5. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.