Effects of MCI-154 on vascular reactivity and its mechanisms after hemorrhagic shock in rats

Journal of Cardiovascular Pharmacology

Volumn 47, Issue 6, 2006, Pages 751-757

  Yang, Guangming ^a   Liu, Liangming ^a   Xu, Jing ^a   Li, Tao ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hemorrhagic shock; MCI 154; PKC; PKG; Rho kinase; Vascular reactivity

Indexed keywords

4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; ANGIOTENSIN II; CALCIUM ION; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; KT 5823; PROTEIN KINASE C; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXTRACELLULAR CALCIUM; HEART MUSCLE CONTRACTILITY; HEMORRHAGIC SHOCK; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SUPERIOR MESENTERIC ARTERY OBSTRUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CALCIUM; CARDIOTONIC AGENTS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENTERIC ARTERY, SUPERIOR; MUSCLE, SMOOTH, VASCULAR; NOREPINEPHRINE; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PYRIDAZINES; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; SHOCK, HEMORRHAGIC; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VEINS;

EID: 33748109732     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000211790.14787.e7     Document Type: Article

References (33)

1. Lee HC, Lum BK. Protective action of calcium entry blockers in endotoxin shock. Circ Shock. 1986;18:193-203.
2. 2+ overload. J Cardiovasc Electrophysiol. 2002;13:1017-1024.
3. Chintala MS, Jandhyala BS. Renal failure in haemorrhagic shock in dogs: salutary effects of the calcium entry blocker felodipine. Naunyn Schmiedebergs Arch Pharmacol. 1990;341:357-363.
4. Xu J, Liu LM. The role of calcium desensitization in vascular hyporeactivity and its regulation after hemorrhagic shock in the rat. Shock. 2005;23:576-581.
5. Liu LM, Ward JA, Dubick MA. Hemorrhage-induced vascular hyporeactivity to norepinephrine in select vasculatures of rats and the roles of nitric oxide and endothelin. Shock. 2003;19:208-214.
6. Md S, Moochhala SM, Siew-Yang KL. The role of inducible nitric oxide synthase inhibitor on the arteriolar hyporesponsiveness in hemorrhagic-shocked rats. Life Sci. 2003;73:1825-1834.
7. 2+ sensitivity of the contractile system by MCI-154, a novel cardiotonic agent, in chemically skinned fibers from the guinea pig papillary muscles. J Pharmacol Exp Ther. 1987; 243:633-638.
8. 2+ activated myosin ATPase activity in ventricular myofibrils from non-failing and diseased human hearts - effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine. Mol Cell Biochem. 2003;245:77-89.
9. Mei JM, Hu DY, Chen HS, et al. Effect of MCI-154, a calcium sensitizer on calcium sensitivity of myocardial fibers in endotoxic shock rats. Shock. 2000;14:652-656.
10. Yin ZM, Hu DY, Liu LM, et al. Protective function of a new calcium sensitizer MCI-154 on myocardium of hemorrhagic shock animals. Chin J Traumatol. 2000;16:163-165.
11. Mei JM, Hu DY, Chen HS, et al. Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits. Shock. 2000;13:459-463.
12. Andrea JE, Walsh MP. Protein kinase C of smooth muscle. Hypertension 1992;20:585-589.
13. Hashitani H, Chen G, Ono H, et al. Electrophysiological comparison of the effects of MCI-154 on smooth muscles between mesenteric artery and vein of dogs. General Pharmacol: Vascular System. 1993;24:333-340.
14. Thiemermann C, Szabo C, Mitchell JA, et al. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci U S A. 1993;90:267-271.
15. Liu LM, Ward JA, Dubick MA. Effects of crystalloid and colloid resuscitation on hemorrhage-induced vascular hyporesponsiveness to norepinephrine in the rat. J Trauma. 2003;54:159-168.
16. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rhokinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522:177-185.
17. 2+ sensitization by PKC and Rho protein in ovine cerebral arteries: effects on artery size and age. Am J Physiol. 1998;275:H930-H939.
18. Touyz RM, Berry C. Recent advances in angiotensin II signaling. Braz J Med Biol Res. 2002;35:1001-1015.
19. Kitada Y, Narimatsu A, Suzuki R, et al. Does the positive inotropic action of a novel cardiotonic agent, MCI-154, involve mechanisms other than cyclic AMP? J Pharmacol Exp Ther. 1987;243:639-645.
20. Suh SH, Chen G, Xue L, et al. Inhibitory actions of MCI-154 on guinea-pig femoral artery and vein preparations. Eur J Pharmacol. 1992;219:377-383.
21. Kitada Y. MCI-154-induced relaxation in vascular smooth muscles of guinea pig. J Cardiovasc Pharmacol. 1996;27:519-526.
22. 45Ca influx in isolated vascular smooth muscles. Eur J Pharmacol. 1988;145:113-121.
23. Mathew L, Katz SD. Calcium sensitizing agents in heart failure. Drugs Aging. 1998;12:191-198.
24. 2+-sensitizer" MCI-154 in intact pigs. Scand Cardiovasc J. 2002;36:172-179.
25. Bauer J, Parekh N. Signal transduction by Rho-kinase in renal circulation. Nephrol Dial Transplant. 2003;18:594-599.
26. Shimokawa H. Cellular and molecular mechanisms of coronary artery spasm - lessons from animal models. Jap J Circulation. 2000;64:1-12.
27. Horowitz A, Menice CB, Laporte R, et al. Mechanisms of smooth muscle contraction. Physiol Rev. 1996;76:967-1003.
28. Touyz RM, El Mabrouk M, He G, et al. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circ Res. 1999;84:505-515.
29. Bethke T, Meyer W, Schmitz W, et al. High selectivity for inhibition of phosphodiesterase III and positive inotropic effects of MCI-154 in guinea pig myocardium. J Cardiovasc Pharmacol. 1993;21:847-855.
30. Sellin LC, Alajoutsijarvi A, Tornquist K, et al. Inhibition of cardiac phosphodiesterase III by the novel cardiotonic agent 6-[4-(40′-pyridyl) aminophenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride. Arzneim Forsch. 1988;38:1787-1789.
31. 2+ sensitivity and inhibit phosphodiesterase III. Jpn J Pharmacol. 1991;55:43P.
32. 2+ regulated interactions between troponin subunits from bovine heart. J Pharmacol Exp Ther. 1994;270:831-839.
33. 2+ sensitivity of reconstituted thin filament: a study using a novel in vitro motility assay technique. Circ Res. 1995; 76:626-633.