Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits

Shock

Volumn 13, Issue 6, 2000, Pages 459-463

  Ming, Mei Jian ^a   Hu, DeYao ^a   Chen, Hui Sun ^a   Liu, Liang Ming ^a   Nan, Xiao ^a   Lu, Ru Quan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Calcium overload; Cardiotonic agent; Myocardial contractility; Myofilament calcium sensitivity; Sepsis septic shock

Indexed keywords

4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; CALCIUM; LIPOPOLYSACCHARIDE; PYRIDAZINE DERIVATIVE;

ANIMAL; ARTICLE; DRUG EFFECT; DRUG SCREENING; FEMALE; HEART CONTRACTION; HEART DISEASE; HEART FUNCTION TEST; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; MALE; PHYSIOLOGY; PILOT STUDY; RABBIT; SEPTIC SHOCK;

ANIMALS; CALCIUM; DRUG EVALUATION, PRECLINICAL; FEMALE; HEART DISEASES; HEART FUNCTION TESTS; HEMODYNAMIC PROCESSES; LIPOPOLYSACCHARIDES; MALE; MYOCARDIAL CONTRACTION; PILOT PROJECTS; PYRIDAZINES; RABBITS; SHOCK, SEPTIC; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 0034199799     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200006000-00007     Document Type: Article

References (24)

1. Hulsman WC, Lamers JMJ, Stam H, Breeman WAP: Calcium overload in endotoxemia. Life Sci 29:1009-1014, 1981.
2. Dong LW, Tong LJ, Zhang L, Su JY, Tang CS: Changes of calcium transport capacity of myocardium of myocardium and myocardial mitochondria during sepsis. Acta Physiologa Sinica 45:158-163, 1993.
3. Hung J, Lew WYW. Cellular mechanisms of endotoxin-induced myocardial depression in rabbits. Circ Res 73:125-134, 1993.
4. 2+ as an inotropic mechanism. Circulation 73(Suppl III):85-98, 1986.
5. Narimatsu A, Kitada Y, Satoh N, Suzuki R, Okushima H: Cardiovascular pharmacology of 6-[OBR]4-(4′pyridyl) aminophenyl[CBR]-4,5-dihydro-3(2H)-pyridazinone hydrochloride, a novel and potent cardiotonic agent with vasodilator properties. Arzneimittlforsch/ Drug Res 37:398-406, 1987.
6. 2+ binding by MCI-154, a novel cardiotonic agent. J Pharmacol Exp Ther 250:272-277, 1989.
7. 2+ sensitivity of reconstitued thin filament: a study using a novel in vitro motility assay technique. Circ Res 76:626-633, 1995.
8. Methew L, Katz SD: Calcium sensitsing agents in heart failure. Drugs Aging 12:191-204, 1998.
9. Liu LM, Hu DY, Chen HS, Lu RQ, Yan W: The importance of δ and κ opioid receptors in the property of thyrotropin-releasing hormone against hemorrhagic shock. Shock 7:60-64, 1997.
10. Abel FL: Does the heart fail in endotoxin shock. Circ Shock 30:5-13, 1990.
11. Goldfarb RD, Lee KJ, Andrejuk T, Dziuban SW, Jr: End-systolic elastance as an evaluation of myocardial function in shock. Circ Shock 30:15-26, 1990.
12. Sugi K, Newald J, Traber LD, Maguira JP, Herndou DN, Schlag G, Traber D:. Cardiac dysfunction after acute endotoxin administration in conscious sheep. Am J Physiol 260:H1474-H1481, 1991.
13. Parker JL, Adams HR. Isolated cardiac preparations: models of intrinsic myocardial dysfunction in circulatory shock. Circ Shock 15:227-245, 1985.
14. Narimatsu A, Kitada Y, Satoh N, Morita M, Muroyama A, Kobayashi M, Ohizumi Y. In vitro characterization of the effects of MCI-154, a novel cardiotonic agent, on cardiac tissues. Jpn J Pharmacol 49:397-405, 1989.
15. Kitada Y, Narimatsu A, Susuki R, Endoh M, Taira N. Does the positive inotropic action of a novel cardiotonic agent, MCI-154, involve mechanisms other than cyclic AMP? J Pharmacol Exp Ther 240:639-645, 1987.
16. Teramura S, Yamakado T: Calcium sensitizers in chronic heart failure: inotropic interventions?reservation to preservation. Cardiologia 43:375-385, 1998.
17. 2+-regulated interactions between troponin subunits from bovine heart. J Pharmacol Exp Ther 270:831-837, 1994.
18. Albert JA, Adams HK: Inotropic and chronotropic profile of MCI-154: comparison with isoproterenol and imazodan in guinea pig cardiac preparations. J Cardiovasc Pharmacol 16:59-67, 1990.
19. 2+ sensitization with a new cardiotonic agent, MCI-154, on diseased human hearts. Cardiovasc Res 30;915-922, 1995.
20. 2+ sensitizer, on ventricular arrhythmias and membrane ionic currents. Eur J Pharmacol 298:247-256, 1996.
21. Teramura S, Yamakada T, Maeda M, Nakano T. Effects of MCI-154, a calcium sensitizer, on left ventricular systolic and diastolic function in pacing-induced heart failure in the dog. Circulation 95:732-739, 1997.
22. Iwamoto H: Effects of a cardiotonic agent, MCI-154, on the contractile properties of skinned skeletal muscle fibers. Eur J Pharmacol 34:243-252, 1998.
23. Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yamakama H, Yokoyama M: Oxygen-saving effects of a new cardiotonic agent, MCI-154, in diseased human hearts. J Am Coll Cardiol 29:613-622, 1997.
24. 2+ sensitizer, deceases the oxygen cost of contractility in isolated canine hearts. Am J Physiol 273:H1688-H1695, 1997.