Epigenetic Silencing of Genes in Human Colon Cancer

Gastroenterology

Volumn 131, Issue 3, 2006, Pages 960-962

  Liddle, Rodger A ^a   Jirtle, Randy L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; BRCA1 PROTEIN; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; PROTEIN P16; SOMATOSTATIN; SUBSTANCE P; TACHYKININ;

COLON CARCINOMA; DNA DETERMINATION; DNA METHYLATION; DNA SEQUENCE; EDITORIAL; ENVIRONMENT; EPIGENETICS; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE SILENCING; GENE TARGETING; HUMAN; METHYLATION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION;

EID: 33748103721     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.07.028     Document Type: Editorial

References (18)

1. Feinberg A.P., and Tycko B. The history of cancer epigenetics. Nat Rev Cancer 4 (2004) 143-153
2. Bird A. The essentials of DNA methylation. Cell 70 (1992) 5-8
3. Coleman W.B., and Rivenbark A.G. Quantitative DNA methylation analysis: the promise of high-throughput epigenomic diagnostic testing in human neoplastic disease. J Mol Diagn 8 (2006) 152-156
4. Rakyan V.K., Chong S., Champ M.E., Cuthbert P.C., Morgan H.D., Luu K.V., and Whitelaw E. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100 (2003) 2538-2543
5. Fuks F. DNA methylation and histone modifications: teaming up to silence genes. Curr Opin Genet Dev 15 (2005) 490-495
6. Feinberg A.P. The epigenetics of cancer etiology. Semin Cancer Biol 14 (2004) 427-432
7. Jones P.A., and Baylin S.B. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3 (2002) 415-428
8. Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349 (2003) 2042-2054
9. Costello J.F., Fruhwald M.C., Smiraglia D.J., Rush L.J., Robertson G.P., Gao X., Wright F.A., Feramisco J.D., Peltomaki P., Lang J.C., Schuller D.E., Yu L., Bloomfield C.D., Caligiuri M.A., Yates A., Nishikawa R., Su Huang H., Petrelli N.J., Zhang X., O'Dorisio M.S., Held W.A., Cavenee W.K., and Plass C. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet 24 (2000) 132-138
10. Ohtani-Fujita N., Fujita T., Aoike A., Osifchin N.E., Robbins P.D., and Sakai T. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8 (1993) 1063-1067
11. Baylin S.B. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2 Suppl 1 (2005) S4-S11
12. Matsubara N. Diagnostic application of hMLH1 methylation in hereditary non-polyposis colorectal cancer. Dis Markers 20 (2004) 277-282
13. Mori Y., Cai K., Cheng Y., Wang S., Paun B., Hamilton J.P., Jin Z., Sato F., Berki A.T., Kan T., Ito T., Mantzur C., Abraham J.M., and Meltzer S.J. A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer. Gastroenterology 131 (2006) 797-808
14. Reubi J.C., and Laissue J.A. Multiple actions of somatostatin in neoplastic disease. Trends Pharmacol Sci 16 (1995) 110-115
15. Massari D., Trobonjac Z., Rukavina D., and Radosevic-Stasic B. SMS 201-995 enhances S-phase block induced by 5-fluorouracil in a human colorectal cancer cell line. Anticancer Drugs 16 (2005) 989-996
16. Casini Raggi C., Calabro A., Renzi D., Briganti V., Cianchi F., Messerini L., Valanzano R., Cameron Smith M., Cortesini C., Tonelli F., Serio M., Maggi M., and Orlando C. Quantitative evaluation of somatostatin receptor subtype 2 expression in sporadic colorectal tumor and in the corresponding normal mucosa. Clin Cancer Res 8 (2002) 419-427
17. Koon H.W., Zhao D., Na X., Moyer M.P., and Pothoulakis C. Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 279 (2004) 45519-45527
18. Ogasawara M., Murata J., Ayukawa K., and Saimi I. Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro. Cancer Lett 116 (1997) 111-116