Neuroendocrine and neurotransmitter correlates in children with antisocial behavior

Hormones and Behavior

Volumn 50, Issue 4, 2006, Pages 647-654

  van Goozen, Stephanie H M ^a,b   Fairchild, Graeme ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Aggression; Conduct disorder; Cortisol; Gender differences; HPA axis; Serotonin; Sex hormones

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HYDROCORTISONE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEX HORMONE;

AGGRESSION; ANTISOCIAL BEHAVIOR; ARTICLE; ASSOCIATION; CHILD; CONFLICT; CONGENITAL ADRENAL HYPERPLASIA; FEAR; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOREACTIVITY; INSTRUMENTAL CONDITIONING; LIFE EVENT; MOLECULAR INTERACTION; NEUROBIOLOGY; NEUROSECRETORY CELL; NEUROTRANSMITTER RELEASE; PREDICTION; PRIORITY JOURNAL; PUNISHMENT; SEROTONINERGIC NERVE CELL; SEX DIFFERENCE; SOCIALIZATION; VIOLENCE;

AGGRESSION; ANTISOCIAL PERSONALITY DISORDER; CHILD; CHILD BEHAVIOR DISORDERS; FEMALE; GONADAL STEROID HORMONES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; SEROTONIN; SEX CHARACTERISTICS; STRESS; STRESS, PHYSIOLOGICAL;

EID: 33748100566     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2006.06.021     Document Type: Article

References (86)

1. Albert D., Walsh M., and Jonik R. Aggression in humans: what is its biological foundation?. Neuroscience and Biobehavioral Reviews 17 (1993) 405-425
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth edition (1994), American Psychiatric Association, Washington, DC
3. Archer J. The influence of testosterone on human aggression. British Journal of Psychology 82 (1991) 1-28
4. Archer J., Graham-Kevan N., and Davies M. Testosterone and aggression: a reanalysis of Book, Starzyk, Quinsey's (2001) study. Aggression and Violent Behaviour 10 (2005) 241-261
5. Bagdy G. Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses. Behavioural Brain Research 73 (1996) 277-280
6. Bardone A.M., Moffitt T.E., Caspi A., Dickson N., Stanton W.R., and Silva P.A. Adult physical health outcomes of adolescent girls with conduct disorder, depression and anxiety. Journal of the American Academy of Child and Adolescent Psychiatry 37 (1998) 594-601
7. Berenbaum S.A., and Resnick S.M. Early androgen effects on aggression in children and adults with congenital adrenal hyperplasia. Psychoneuroendocrinology 22 7 (1997) 505-515
8. Berenbaum S.A., Duck S.C., and Bryk K. Behavioral effects of prenatal versus postnatal androgen excess in children with 21-hydroxylase-deficient congenital adrenal hyperplasia. The Journal of Clinical Endocrinology and Metabolism 85 2 (2000) 727-733
9. Blanchard R.J., and Blanchard D.C. Aggressive behavior in the rat. Behavioral Biology 21 (1977) 197-224
10. Bremner J.D., and Vermetten E. Stress and development: behavioral and biological consequences. Development and Psychopathology 13 (2001) 473-489
11. Brennan P.A., Rain A., Schulsinger F., et al. Psychophysiological protective factors for male subjects at high risk for criminal behavior. American Journal of Psychiatry 154 (1997) 853-855
12. Caspi A., McClay J., Moffitt T.E., Mill J., Martin J., Craig I.W., Taylor A., and Poulton R. Role of the genotype in the cycle of violence in maltreated children. Science 297 (2002) 851-854
13. Castellanós F.X., Elia J., Kruesi M.J., Gulotta C.S., Mefford I.N., Potter W.Z., Ritchie G.F., and Rapoport J.L. Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Research 52 (1994) 305-316
14. Chalmers D.T., Kwak S.P., Mansour A., Akil H., and Watson S.J. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. Journal of Neuroscience 13 (1993) 914-923
15. Chaouloff F. Regulation of 5-HT receptors by corticosteroids: where do we stand?. Fundamental & Clinical Pharmacology 9 (1995) 219-233
16. Coccaro E.F., Kavoussi R.J., Cooper T.B., and Hauger R.L. Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. American Journal of Psychiatry 154 (1997) 1430-1435
17. Collaer M.L., and Hines M. Human behavioural sex differences: a role for gondal hormones during early development?. Psychological Bulletin 118 (1995) 55-107
18. Conger R.D., Ge X., Elder G.H., Lorenz F.O., and Simons R.L. Economic stress, coercive family process, and developmental problems of adolescents. Child Development 65 (1994) 541-561
19. Cook Jr. E.H., Stein M.A., Ellison T., Unis A.S., and Leventhal B.L. Attention deficit hypeactivity disorder and whole-blood serotonin levels: effects of comorbidity. Psychiatry Research 57 (1995) 13-20
20. Cyranowski J.M., Frank E., Young E., and Shear K. Adolescent onset of the gender difference in lifetime rates of major depression. Archives of General Psychiatry 57 (2000) 21-27
21. Dewing P., Shi T., Horvath S., and Vilain E. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Molecular Brain Research 118 (2003) 82-90
22. Dixson A.F. Androgens and aggressive behavior in primates: a review. Aggressive Behavior 6 (1980) 37-67
23. Eberhart J.A., Keverne E.B., and Meller R.E. Social influences on plasma testosterone levels in male Talapoin monkeys. Hormones and Behavior 14 (1980) 247-266
24. Erel O., and Burman B. Interrelatedness of marital relations and parent-child relations: a meta-analytic review. Psychological Bulletin 118 (1995) 108-132
25. Fairchild G., Leitch M.M., and Ingram C.D. Acute and chronic effects of corticosterone on 5-HT1A receptor-mediated autoinhibition in the rat dorsal raphe nucleus. Neuropharmacology 45 (2003) 925-934
26. Foley D.L., Eaves L.J., Wormley B., Silberg J.L., Maes H.H., Kuhn J., and Riley B. Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry 61 (2004) 738-744
27. Fombonne E., Wostear G., Cooper V., Harrington R., and Rutter M. The Maudsley long-term follow-up of child and adolescent depression: I. Psychiatric outcomes in adulthood. British Journal of Psychiatry 179 (2001) 210-217
28. Fuller R.W. The involvement of serotonin in regulation of pituitary-adrenocortical function. Frontiers in Neuroendocrinology 13 (1992) 250-270
29. Goy R.W., and McEwen B.S. Sexual Differentiation of the Brain (1980), MIT Press, Cambridge, MA
30. Halász J., Liposits Z., Kruk M.R., and Haller J. Neural background of glucocorticoid dysfunction-induced abnormal aggression in rats: involvement of fear- and stress-related structures. European Journal of Neuroscience 15 (2002) 561-569
31. Haller J., van de Schraaf J., and Kruk M.R. Deviant forms of aggression in glucocorticoid hyporeactive rats: a model for 'pathological' aggression?. Journal of Neuroendocrinology 13 (2001) 102-107
32. Haller J., Halász J., Mikics E., and Kruk M.R. Chronic glucocorticoid deficiency-induced abnormal aggression, autonomic hypoarousal, and social deficit in rats. Journal of Neuroendocrinology 16 (2004) 550-557
33. Halperin J.M., Sharma V., Siever L.J., Schwartz S.T., Matier K., Wornell G., and Newcorn J.H. Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. American Journal of Psychiatry 151 (1994) 243-248
34. Halperin J.M., Newcorn J.H., Kopstein I., McKay K.E., Schwartz S.T., Siever L.J., and Sharma V. Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 36 (1997) 1391-1398
35. Hanna G.L., Yuwiler A., and Coates J.K. Whole blood serotonin and disruptive behaviors in juvenile obsessive-compulsive disorder. Journal of the American Academy of Child and Adolescent Psychiatry 34 (1995) 28-35
36. Harris J.A. Review and methodological considerations in research on testosterone and aggression. Aggression and Violent Behaviour 4 3 (1999) 273-291
37. Hines M. Brain Gender (2004), Oxford University Press
38. Hines M., and Green R. Human hormonal and neural correlates of sex-typed behaviors. Review of Psychiatry 10 (1991) 536-555
39. Hines M., Golombok S., Rust J., Johnston K.J., Golding J., and The Avon Longitudinal study of parents and children study team. Testosterone during pregnancy and gender role behavior of preschool children: a longitudinal, population study. Child Development 73 6 (2002) 1678-1687
40. Hughes C.W., Petty F., Shiekha S., and Kramer G.L. Whole-blood serotonin in children and adolescents with mood and behavior disorders. Psychiatry Research 65 (1996) 79-95
41. Kazdin A. Conduct Disorders in Childhood and Adolescence. 2nd ed. (1995), Sage, Thousand Oaks, CA
42. Kazdin A. Treatment of conduct disorders. In: Hill J., and Maughan B. (Eds). Conduct Disorders in Childhood and Adolescence (2001), Cambridge University Press, Cambridge 408-448
43. Kruesi M.J., Rapoport J.L., Hamburger S., Hibbs E., Potter W.Z., Lenane M., and Brown G.L. Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Archives of General Psychiatry 47 (1990) 419-426
44. Kruesi M.J., Hibbs E.D., Zahn T.P., Keysor C.S., Hamburger S.D., Bartko J.J., and Rapoport J.L. A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Prediction by cerebrospinal fluid 5-hydroxyindole-acetic acid, homovanillic acid, and autonomic measures?. Archives of General Psychiatry 49 (1992) 429-435
45. Kruijver F.P., Balesar R., Espila A.M., Unmehopa U.A., and Swaab D.F. Estrogen receptor-alpha distribution in the human hypothalamus in relation to sex and endocrine status. Journal of Comparative Neurology 454 (2002) 115-139
46. Kruijver F.P., Balesar R., Espila A.M., Unmehopa U.A., and Swaab D.F. Estrogen-receptor-β distribution in the human hypothalamus: similarities and differences with ERα distribution. Journal of Comparative Neurology 466 (2003) 251-277
47. Lahey B.B., McBurnett K., Loeber R., and Hart E.L. Psychobiology. In: Perooz Sholevar G. (Ed). Conduct Disorders in Children and Adolescents (1995), American Psychiatric Press, Washington, DC 27-44
48. Lahey B.B., Waldman I.D., and McBurnett K. Annotation: the development of antisocial behavior: an integrative causal model. Journal of Child Psychology and Psychiatry 40 (1999) 669-682
49. Lidberg L., Tuck J.R., Asberg M., Scalia-Tomba G.P., and Bertilsson L. Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica 71 (1985) 230-236
50. Limson R., Goldman D., Roy A., Lamparski D., Ravitz B., Adinoff B., and Linnoila M. Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Archives of General Psychiatry 48 (1991) 437-441
51. Liu D., Diorio J., Tannenbaum B., Caldji C., Francis D., Freedman A., Sharma S., Pearson D., Plotsky P.M., and Meaney M.J. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277 (1997) 1659-1662
52. Loeber R., and Hay D.F. Key issues in the development of aggression and violence from childhood to early adulthood. Annual Review of Psychology 48 (1997) 371-410
53. Lynam D.R. identification of early offenders: who is the fledgling psychopath?. Psychological Bulletin 120 (1996) 209-234
54. Mazur A., and Booth A. Testosterone and dominance in men. Behavioral and Brain Sciences 21 (1998) 353-397
55. Meaney M.J., Diorio J., Francis D., Widdowson J., Laplante P., Caldji C., Sharma S., Seckl J.R., and Plotsky P.M. Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Developmental Neuroscience 18 (1996) 49-72
56. Offord D.R., and Bennett K.J. Conduct disorder: long-term outcomes and intervention effectiveness. Journal of the American Academy of Child and Adolescent Psychiatry 33 (1994) 1069-1078
57. Offord D.R., Boyle M.H., Racine Y.A., Fleming J.E., Cadman D.T., Blum H.M., Byrne C., Links P.S., Lipman E.L., MacMillan H.L., et al. Outcome, prognosis, and risk in a longitudinal follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry 31 (1992) 916-923
58. O'Keane V., Moloney E., O'Neill H., O'Connor A., Smith C., and Dinan T.G. Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function. British Journal of Psychiatry 160 (1992) 643-646
59. Pine D.S., Coplan J.D., Wasserman G.A., Miller L.S., Fried J.E., Davies M., Cooper T.B., Greenhill L., Shaffer D., and Parsons B. Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing. Archives of General Psychiatry 54 (1997) 839-846
60. Pliszka S.R., Rogeness G.A., Renner P., Sherman J., and Broussard T. Plasma neurochemistry in juvenile offenders. Journal of the American Academy of Child and Adolescent Psychiatry 27 (1988) 588-594
61. Plomin R., Nitz K., and Rowe D.C. Behavioral genetics and aggressive behavior in childhood. In: Lewis M., and Miller S.M. (Eds). Handbook of Developmental Psychopathology (1990), Plenum, New York 119-133
62. Porter R.J., Gallagher P., Watson S., and Young A.H. Corticosteroid-serotonin interactions in depression: a review of the human evidence. Psychopharmacology 173 (2004) 1-17
63. Raine A. Autonomic nervous system activity and violence. In: Stoff D.M., and Cairns R.B. (Eds). Aggression and Violence. Genetic, Neurobiological and Biological Perspectives (1996), Lawrence Erlbaum Associates, Mahwah, NJ 145-168
64. Raine A., Venables P.H., and Williams M. Relationships between central and autonomic measures of arousal at age 15 years and criminality at age 24 years. Archives of General Psychiatry 47 (1990) 1003-1007
65. Raine A., Venables P.H., and Mednick S.A. Low resting heart rate at age 3 years predisposes to aggression at age 11 years: evidence from the Mauritius Child Health Project. Journal of the American Academy of Child and Adolescent Psychiatry 36 (1997) 1457-1464
66. Reinisch J.M. Prenatal exposure to synthetic progestins increases potential for aggression in humans. Science 211 (1981) 561-562
67. Robins L.N. Deviant Children Grown Up (1966), Williams and Wilkins, Baltimore, MD
68. Rogeness G.A., Hernandez J.M., Macedo C.A., and Mitchell E.L. Biochemical differences in children with conduct disorder socialized and undersocialized. American Journal of Psychiatry 139 (1982) 307-311
69. 1B receptor. Science 265 (1994) 1875-1878
70. Snoek H., van Goozen S.H.M., Matthys W., Sigling H.O., Koppeschaar H.P.F., Westenberg H.G.M., and van Engeland H. Serotonergic functioning in children with oppositional defiant disorder: a sumitriptan challenge study. Biological Psychiatry 51 (2002) 319-325
71. Snoek H., Van Goozen S.H.M., Matthys W., Buitelaar J.K., and Van Engeland H. Stress responsivity in children with externalizing behavior disorders. Development and Psychopathology 16 (2004) 389-406
72. Sobczak S., Honig A., Nicolson N., and Riedel W.J. Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controls. Neuropsychopharmacology 27 (2002) 834-842
73. Spoont M.R. Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychological Bulletin 112 (1992) 330-350
74. Tennes K., and Kreye M. Children's adrenocortical responses to classroom activities and tests in elementary school. Psychosomatic Medicine 47 (1985) 451-460
75. Tennes K., Kreye M., Avitable N., and Wells R. Behavioral correlates of excreted catecholamines and cortisol in second-grade children. Journal of the American Academy of Child and Adolescent Psychiatry 25 (1986) 764-770
76. Tuinier S., Verhoeven W.M.A., and Van Praag H.M. Serotonin and disruptive behavior; a critical evaluation of the clinical data. Human Psychopharmacology 11 (1996) 469-482
77. Unis A.S., Cook E.H., Vincent J.G., Gjerde D.K., Perry B.D., Mason C., and Mitchell J. Platelet serotonin measures in adolescents with conduct disorder. Biological Psychiatry 42 (1997) 553-559
78. Van de Wiel N.M.H., Van Goozen S.H.M., Matthys W., Snoek H., and Van Engeland H. Cortisol and treatment effect in children with disruptive behavior disorders: a preliminary study. Journal of the American Academy of Child and Adolescent Psychiatry 43 (2004) 1011-1018
79. Van Goozen S.H.M. Hormones and the developmental origins of aggression. In: Tremblay R.E., Hartup W.W., and Archers J. (Eds). Developmental Origins of Aggression (2005), The Guilford Press, New York 281-306
80. Van Goozen S.H.M., Matthys W., Cohen-Kettenis P.T., Gispen-de Wied C., Wiegant V.M., and Van Engeland H. Salivary cortisol and cardiovascular activity during stress in oppositional-defiant disorder boys and normal controls. Biological Psychiatry 43 (1998) 531-539
81. Van Goozen S.H.M., Matthys W., Cohen-Kettenis P.T., Westenberg H., and Van Engeland H. Plasma monoamine metabolites and aggression: two studies of normal and oppositional defiant disorder children. European Neuropsychopharmacology 9 (1999) 141-147
82. Van Goozen S.H.M., Fairchild G., Snoek H., and Harold G.W. The evidence for a neurobiological model of childhood antisocial behavior. Psychological (2000)
83. Van Goozen S.H.M., Matthys W., Cohen-Kettenis P.T., Buitelaar J.K., and Van Engeland H. Hypothalamic-pituitary-adrenal axis and autonomic nervous system activity in disruptive children and matched controls. Journal of the American Academy of Child and Adolescent Psychiatry 39 (2000) 1438-1445
84. Vanyukov M.M., Moss H.B., Plail J.A., Blackson T., Mezzich A.C., and Tarter R.E. Antisocial symptoms in preadolescent boys and in their parents: associations with cortisol. Psychiatry Research 46 (1993) 9-17
85. Virkkunen M., Nuutila A., Goodwin F.K., and Linnoila M. Cerebrospinal fluid monoamine metabolites in male arsonists. Archives of General Psychiatry 44 (1987) 241-247
86. Zuckerman M. Sensation Seeking: Beyond the Optimum Level of Arousal (1979), Lawrence Erlbaum Associates, Hillsdale, NJ