Systemic and mucosal antibody response in experimental Chlamydia pneumoniae infection of mice

Comparative Medicine

Volumn 56, Issue 4, 2006, Pages 272-278

  Penttilä, Tuula ^a,b   Wahlström, Eva ^b,d   Vuola, Jenni M ^b,e   Sarvas, Matti ^b   Puolakkainen, Mirja ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e GLAXOSMITHKLINE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN A; MAJOR OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN 2; OUTER MEMBRANE PROTEIN 4; OUTER MEMBRANE PROTEIN A; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BACILLUS SUBTILIS; BRONCHUS SECRETION; CHLAMYDIASIS; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; EXPERIMENTAL INFECTION; FEMALE; GENE EXPRESSION SYSTEM; MOUSE; MUCOSA; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CHAPERONIN 60; CHLAMYDIA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 33748052988     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Airaksinen U, Penttilä T, Wahlström E, Vuola JM, Puolakkainen M, Sarvas M. 2003. Production of Chlamydia pneumoniae proteins in Bacillus subtilis and their use in characterizing immune responses in the experimental infection model. Clin Diagn Lab Immunol 10:367-375
2. Beatty WL, Morrison RP, Byrne GI. 1994. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev 58:686-699.
3. Betsou F, Sueur JM, Orfila J. 2003. Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults. FEMS Immunol Med Microbiol 35:107-111.
4. Birkelund S, Knudsen K, Madsen AS, Falk E, Mygind P, Christiansen G, 1998. Differential expression of Chlamydiae pneumoniae Omp4 and Omp5 after infection of C57-Black mice. In Stephens RS, Byrne GI, Christiansen G, Clarke IN, Grayston JT, Rank RG, Ridgway GL, Saikku P, Schachter J, Stamm WE, editors. Chlamydial infections: proceedings of the ninth international symposium on human chlamydial infection; 1998 June; San Francisco, CA. San Francisco: International Chlamydia Symposium, p 275-278.
5. Campbell LA, Kuo CC, Grayston JT. 1990. Structural and antigenic analysis of Chlamydia pneumoniae. Infect Immun 58:93-97.
6. Campbell LA, Kuo CC, Wang SP, Grayston JT. 1990. Serological response to Chlamydia pneumoniae infection. J Clin Microbiol 28:1261-1264.
7. Campbell LA, Roberts S, Inoue S, Kong L, Kuo CC. 2001. Evaluation of Chlamydia pneumoniae 43- and 53-kilodalton recombinant proteins for serodiagnosis by Western blot. Clin Diagn Lab Immunol 8:1231-1233.
8. Debattista J, Timms P, Allan J. 2003. Immunopathogenesis of Chlamydia trachomatis infections in women. Fertil Steril 79:1273-1287.
9. Eckert LO, Hawes SE, Wolner-Hanssen P, Money DM, Peeling RW, Brunham RC, Stevens CE, Eschenbach DA, Stamm WE. 1997. Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. J Infect Dis 175:1453-1458.
10. Essig A, Simnacher U, Susa M, Marre R. 1999. Analysis of the humoral immune response to Chlamydia pneumoniae by immunoblotting and immunoprecipitation. Clin Diagn Lab Immunol 6:819-825.
11. Everett KD, Hatch TP. 1995. Architecture of the cell envelope of Chlamydia psittaci 6BC. J Bacteriol 177:877-882.
12. Fong IW, Chiu B, Viira E, Tucker W, Wood H, Peeling RW. 2002. Chlamydial heat-shock protein-60 antibody and correlation with Chlamydia pneumoniae in atherosclerotic plaques. J Infect Dis 186:1469-1473.
13. Freidank HM, Herr AS, Jacobs E. 1993. Identification of Chlamydia pneumoniae-specific protein antigens in immunoblots. Eur J Clin Microbiol Infect Dis 12:947-951.
14. Gaydos CA, Summersgill JT, Sahney NN, Ramirez JA, Quinn TC. 1996. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect Immun 64:1614-1620.
15. Grayston JT, Kuo CC, Wang SP, Altman J. 1986. A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N Engl J Med 315:161-168.
16. Grimwood J, Olinger L, Stephens RS. 2001. Expression of Chlamydia pneumonias polymorphic membrane protein family genes. Infect Immun 69:2383-2389.
17. Hahn DL, Dodge RW, Golubjatnikov R. 1991. Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. J Am Med Assoc 266:225-230.
18. Huhtinen M, Puolakkainen M, Laasila K, Sarvas M, Karma A, Leirisalo-Repo M. 2001. Chlamydial antibodies in patients with previous acute anterior uveitis. Invest Ophthalmol Vis Sci 42:1816-1819.
19. Huittinen T, Hahn D, Anttila T, Wahlsttöm E, Saikku P, Leinonen M. 2001. Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma. Eur Respir J 17:1078-1082.
20. Iijima Y, Miyashita N, Kishimoto T, Kanamoto Y, Soejima R, Matsumoto A. 1994. Characterization of Chlamydia pneumoniae species-specific proteins immunodominant in humans. J Clin Microbiol 32:583-588.
21. Kikuta LC, Puolakkainen M, Kuo CC, Campbell LA. 1991. Isolation and sequence analysis of the Chlamydia pneumoniae GroE operon. Infect Immun 59:4665-4669.
22. Knudsen K, Madsen AS, Mygind P, Christiansen G, Birkelund S. 1999. Identification of two novel genes encoding 97- to 99-kilodalton outer membrane proteins of Chlamydia pneumoniae. Infect Immun 67:375-383.
23. Longbottom D, Russell M, Dunbar SM, Jones GE, Herring AJ. 1998. Molecular cloning and characterization of the genes coding for the highly immunogenic cluster of 90-kilodalton envelope proteins from the Chlamydia psittaci subtype that causes abortion in sheep. Infect Immun 66:1317-1324.
24. Melgosa MP, Kuo CC, Campbell LA. 1993. Outer membrane complex proteins of Chlamydia pneumoniae. FEMS Microbiol Lett 112:199-204.
25. Moore T, Ananaba GA, Bolier J, Bowers S, Belay T, Eko FO, Igietseme JU. 2002. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology 105:213-221.
26. Moore T, Ekworomadu CO, Eko FO, MacMillan L, Ramey K, Ananaba GA, Patrickson JW, Nagappan PR, Lyn D, Black CM, Igietseme JU. 2003. Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens. J Infect Dis 188:617-624.
27. Mygind P, Christiansen G, Persson K, Birkelund S. 1998. Analysis of the humoral immune response to Chlamydia outer membrane protein 2. Clin Diagn Lab Immunol 5:313-318.
28. Paavonen J, Lähdeaho ML, Puolakkainen M, Mäki M, Parkkonen P, Lehtinen M. 1994. Antibody response to B cell epitopes of Chlamydia trachomatis 60-kDa heat-shock protein and corresponding mycobacterial and human peptides in infants with chlamydial pneumonitis. J Infect Dis 169:908-911.
29. Pedersen AS, Christiansen G, Birkelund S. 2001. Differential expression of PmplO in cell culture infected with Chlamydia pneumoniae CWL029. FEMS Microbiol Lett 203:153-159.
30. Penttilä JM, Anttila M, Puolakkainen M, Laurila A, Varkila K, Sarvas M, Mäkelä PH, Rautonen N. 1998. Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection. Infect Immun 66:5113-5118.
31. Penttilä T, Vuola JM, Puurula V, Anttila M, Sarvas M, Rautonen N, Mäkelä PH, Puolakkainen M. 2000. Immunity to Chlamydia pneumoniae induced by vaccination with DNA vectors expressing a cytoplasmic protein (Hsp60) or outer membrane proteins (MOMP and Omp2). Vaccine 19:1256-1265.
32. Perez Melgosa M, Kuo CC, Campbell LA. 1991. Sequence analysis of the major outer membrane protein gene of Chlamydia pneumoniae. Infect Immun 59:2195-2199.
33. Puolakkainen M, Parker J, Kuo CC, Grayston JT, Campbell LA. 1995. Further characterization of Chlamydia pneumoniae specific monoclonal antibodies. Microbiol Immunol 39551-554.
34. Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Mäkelä PH, Huttunen JK, Valtonen V. 1988. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet 2:983-986.
35. Stephens RS, Lammel CJ. 2001. Chlamydia outer membrane protein discovery using genomics. Curr Opin Microbiol 4:16-20.
36. Vandahl BB, Birkelund S, Demol H, Hoorelbeke B, Christiansen G, Vandekerckhove J, Gevaert K. 2001. Proteome analysis of the Chlamydia pneumoniae elementary body. Electrophoresis 22:1204-1223.
37. Vandahl BB, Pedersen AS, Gevaert K, Holm A, Vandekerckhove J, Christiansen G, Birkelund S. 2002. The expression, processing, and localization of polymorphic membrane proteins in Chlamydia pneumoniae strain CWL029. BMC Microbiol 2:36.
38. Watson MW, al-Mahdawi S, Lamden PR, Clarke IN. 1990. The nucleotide sequence of the 60 kDa cysteine-rich outer membrane protein of Chlamydia pnewnoniae strain IOL-207. Nucleic Acids Res 18:5299.
39. Williams DM, Grubbs BG, Pack E, Kelly K, Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65:2876-2882.
40. Wolf K, Fischer E, Mead D, Zhong G, Peeling R, Whitmire B, Caldwell HD. 2001. Chlamydia pneumonias major outer membrane protein is a surface-exposed antigen that elicits antibodies primarily directed against conformation- dependent determinants. Infect Immun 69:3082-3091.