Evaluation of the Influence of Antiepileptic Therapy on Antioxidant Enzyme Activity and Lipid Peroxidation in Erythrocytes of Children With Epilepsy

Journal of Child Neurology

Volumn 21, Issue 7, 2006, Pages 558-562

  Sobaniec, Wojciech ^a   Solowiej, Elzbieta ^a   Kulak, Wojciech ^a   Bockowski, Leszek ^a   Smigielska Kuzia, Joanna ^a   Artemowicz, Barbara ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE; CARBAMAZEPINE; ETHOSUXIMIDE; GABAPENTIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LAMOTRIGINE; MALONALDEHYDE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; SUPEROXIDE DISMUTASE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ADOLESCENT; ANTIOXIDANT ACTIVITY; ARTICLE; CELLULAR DISTRIBUTION; CHILD; CHILDHOOD DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; EPILEPSY; ERYTHROCYTE; FEMALE; HUMAN; INFANT; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTICONVULSANTS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EPILEPSY; ERYTHROCYTES; FEMALE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HUMANS; INFANT; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; SUPEROXIDE DISMUTASE;

EID: 33748035379     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/08830738060210070301     Document Type: Article

References (36)

1. Delanty N., Dichter MA: Oxidative injury in the nervous system. Acta Neurol Scand 1998; 98: 145–153.
2. Choi BH: Oxygen, antioxidants and brain dysfunction. Yonsei Med J 1993; 34: 1–10.
3. Frantseva MV, PerezValazquez JL, Tsorakkidis G., et al: Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Neuroscience 2000; 97: 431–435.
4. Patel MN: Oxidative stress, mitochondrial dysfunction, and epilepsy. Free Radic Res 2002; 36: 1139–1146.
5. Sudha K., Rao AV, Rao A.: Oxidative stress and antioxidants in epilepsy. Clin Chim Acta 2001; 303: 19–24.
6. Weber GF, Maertens P., Meng X., Pippenger CE: Glutathione peroxidase deficiency and childhood seizures. Lancet 1991; 337: 1443–1444.
7. Ben-Menachem E., Kyllerman M., Marklund S.: Superoxide dismutase and glutathione peroxidase function in progressive myoclonus epilepsies. Epilepsy Res 2000; 40: 33–39.
8. Sobaniec W., Kulak W., Sobaniec H., et al: Effects of clobazam and vitamin E on the lipid peroxidation in the rat brain after electroconvulsive shock. Ann Acad Med Bialtstok 1999; 44: 134–140.
9. Ono H., Sakamoto A., Sakura N.: Plasma total glutathione concentrations in epileptic patients taking anticonvulsants. Clin Chim Acta 2000; 298: 135–143.
10. Seckin S., Basaran-Kucukgergin C., Uysal M.: Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver. Pharmacol Toxicol 1999; 85: 294–298.
11. Wang JF, Azzam JE, Young LT: Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells. Neuroscience 2003;116: 485–489.
12. Sobaniec W. : Lipid peroxidation in experimental and clinical epilepsy and the effects of sodium valproate and vitamin E on these processes. Neuroscience 1992; 18: 123–130.
13. Mahle C., Dasgupta A.: Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin. Life Sci 1997; 61: 437–443.
14. Liu CS, Wu HM, Kao SH, Wei YH: Phenytoin-mediated oxidative stress in serum of female epileptics possible pathogenesis in the fetal hydantoin syndrome. Hum Exp Toxicol 1997; 16: 177–181.
15. Liu CS, Wu HM, Kao SH, Wei YH: Serum trace elements, glutathione, copper/zinc superoxide dismutase, and lipid peroxidation in epileptic patients with phenytoin or carbamazepine monotherapy. Clin Neuropharmacol 1998; 21: 62–64.
16. Artemowicz B., Sołowiej E., Sobaniec W.: The disturbance of the oxidants-antioxidants balance in epileptic children. Int J Neuroprotec Neuroregen 2004; 1: 27–31.
17. Sobaniec W., Kulak W., Bockowski L., et al: Studies of damages processes in the nervous system and possibilities of neuroprotection Przegl Lek 2001; 58: 41–47.
18. Solowiej E., Sobaniec W.: The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsy Neurol Neuroch Pol 2003; 37: 991— 1003.
19. Sykes JA, McCormack FX, O'Brien TJ: A preliminary study of superoxide dismutase content of some human tumors. Cancer Res 1978; 38: 2759–2762.
20. Paglia DE, Valentine WN: Study on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70: 158–169.
21. Mize CE, Langdon RG: Hepatic glutathione reductase I. Purification and general kinetic properties. J Biol Chem 1962; 237: 1589–1595.
22. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 1978; 51: 302–310.
23. Pippenger CE, Meng X., Van Lente F, Rothner AD: Valproate therapy depresses GSH-Px and SOD enzyme activity. A possible mechanism for VPA induced idiosyncratic drug toxicity. Clin Chem 1989; 35: 1173.
24. Cengiz M., Yuksel A., Seven M.: The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children. Pharmacol Res 2000; 41: 423–425.
25. Niketic V., Ristic S., Saicic ZS, et al: Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (HbASSG) in epileptic patients with long-term antiepileptic therapy. Farmacol 1995; 50: 811–813.
26. Kurekci AE, Alpay F., Tanindi S., et al: Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy. Epilepsia 1995; 36: 600–604.
27. Verrotti A., Basciani F., Trotta D., et al: Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy. Epilepsy Res 2002; 48: 71–75.
28. Cotariu D., Evans S., Lahat E., et al: Inhibition of human red blood cell glutathione reductase by valproic acid. Biochem Pharmacol 1992; 43: 425–429.
29. Yuksel A., Cengiz M., Seven M., Ulutin T.: Erythrocyte glutathione peroxidase, superoxidase dismutase and serum lipid peroxidation in epileptic children valproate and carbamazepine monotherapy. J Basic Clin Physiol Pharmacol 2000; 11: 73–81.
30. Yuksel A., Cengiz M., Seven M., Ulutin T.: Changes in the antioxidant system in epileptic children receiving antiepileptic drugs: Two-year prospective studies. J Child Neurol 2001; 16: 603–606.
31. Graf WD, Oleinik OE, Glauser TA, et al: Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics 1998; 29: 195–201.
32. Maertens P., Dyken P., Graf W., et al: Free radicals, anticonvulsants, and the neuronal ceroid-lipofuscinoses. Am J Med Genet 1995; 57: 225–228.
33. Martinez-Ballesteros C., Pita-Calandre E., Sanches-Gonzalez Y., et al: Lipid peroxidation in adult epileptic patients treated with valproic acid. Rev Neurol 2004; 38: 101–106.
34. Cardile V., Pavone A., Renis M., et al: Biological effects of tiagabine on primary cortical astrocyte cultures of rat. Neurosci Lett 2000; 288: 49–52.
35. Bashkatova VG, Vitskova G., Narkevich VB, et al: The effect of anticonvulsants on the nitric oxide content and level of lipid peroxidation in the brain of rats in model seizure states. Eksp Klin Farmakol 1999; 62: 11–14.
36. Pavone A., Cardile V.: An in vitro study of new antiepileptic drugs and astrocytes. Epilepsia 2003; 44: 34–39.