Synthesis, characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG conjugates

Pharmazie

Volumn 61, Issue 8, 2006, Pages 660-663

  Zhou, Qingsong ^a,b   Jiang, Xuehua ^b   Li, Kejia ^b   Fan, Xingxing ^b  

^a JIANGXI SCIENCE AND TECHNOLOGY NORMAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; SCUTELLAREIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONJUGATION; DRUG ABSORPTION; DRUG STABILITY; IN VITRO STUDY; INTESTINE ABSORPTION; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANIMALS; APIGENIN; BUFFERS; CHEMISTRY, PHYSICAL; GLUCURONIC ACIDS; INTESTINAL ABSORPTION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33748030427     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Artursson P, Karisson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal(caco-2) cells. J Biochem Biophys Res Commun 175: 880-886.
2. Dackson K, Stone JA, Palin KJ (1992) Evaluation of the mass balance assumption with respect to the two-resistance model of intestinal absorption by using in situ sing-pass intestinal perfusion of theophylline in rats. J Pharm Sci 81: 321-325.
3. Frederic EZ, Gregory DB (1979) A mild method for esterification of fatty acids. Synthetic Commun 9: 539-542.
4. Greenwald RB, Choe YH, McGuire J, Conover CD (2003) Effective drug delivery by PEGylated drug conjugates, Adv Drug Del Rev 55: 217-250.
5. Jezyk N, Li C, Stewart BH, Wu XC, Bockbrader HN, Fleisher D (1999) Transport of pregabalin in rat intestine and Caco-2 monolayers. Pharm Res 16: 519-526.
6. Jiang XH, Li SH, Lan K, Yang JY, Zhou J (2003) Study on the pharmacokinetics of scutellarin in dogs. Acta Pharm Sinica 38: 371-373.
7. Lu HH, Thomas J, Fleisher D (1992) Influence of D-glucose-induced water absorption on rat jejunal uptake of two passively absorbed drugs. J Pharm Sci 81: 21-25.
8. Wang H, Cheng JM, Zhang QM (2000) Determination of the physical chemistry constants of baicalin. J Shengyang Pharm Univ 17: 105-106.
9. 1-retinoyl-5-flurouracil. STP Pharm Sci 11: 243-247.