The use of drotrecogin alfa recombinant activated protein C for severe sepsis in the critically burned patient: A new treatment approach

Burns

Volumn 32, Issue 6, 2006, Pages 783-787

  Weintraub, Jennifer ^a   Satterwhite, Thomas ^b   Allo, Maria ^b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROTRECOGIN;

ADULT; ANAMNESIS; APACHE; ARTICLE; BLOOD PRESSURE FLUCTUATION; BURN PATIENT; BURN UNIT; CASE REPORT; CHEMICAL BURN; CLINICAL FEATURE; CONSULTATION; CORE TEMPERATURE; CRITICAL ILLNESS; DISEASE COURSE; DISEASE SEVERITY; DRUG USE; GENERAL CONDITION DETERIORATION; GENERAL CONDITION IMPROVEMENT; HUMAN; INTRAVENOUS ADMINISTRATION; MALE; MEDICAL EXAMINATION; MEDICAL SPECIALIST; PATIENT ASSESSMENT; PATIENT MONITORING; SEPSIS; THERAPY EFFECT; TREATMENT OUTCOME;

ANTI-INFECTIVE AGENTS; BLAST INJURIES; BURNS; CRITICAL ILLNESS; HUMANS; MALE; MIDDLE AGED; PROTEIN C; RECOMBINANT PROTEINS; SEPSIS;

EID: 33747893981     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.burns.2006.02.021     Document Type: Article

References (9)

1. Deitch E.A. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 127 (1992) 152-157
2. Schwacha M.G. Macrophages and post-burn immune dysfunction. Burns 29 (2003) 1-14
3. Zeni F., Freeman B., and Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 25 (1997) 1095-1100
4. Bernard G.R., Vincent J.L., Laterre P.F., et al. Efficacy and safety of recombinant human activated protein c for severe sepsis. NEJM 344 (2001) 699-709
5. Penner J. Antithrombin deficiency in special clinical syndromes-part II: trauma/burns. Semin Hematol 32 4 Suppl. 2 (1995) 42-47
6. Mizutani A., Murakami K., Okajima K., et al. Activated protein C reduces combined burn and smoke inhalation-induced acute lung injury in mice by inhibiting excessive production of nitric oxide. Crit Care Med 32 12 (2004) A24
7. Manns B.J., Lee H.L., Doig C.J., et al. An economic evaluation of activated protein C treatment for severe sepsis. NEJM 347 (2002) 993-1000
8. Cumming J., Purdue G.F., Hunt J.L., et al. Objective estimates of the incidence and consequences of multiple organ dysfunction and sepsis after burn trauma. J Trauma-Injury Infect Crit Care 50 (2001) 510-515
9. Saffle J.R., Sullivan J.J., Tuohig G.M., et al. Multiple organ failure in patients with thermal injury. Crit Care Med 21 (1993) 1673-1683