SCOPUS 정보 검색 플랫폼

Volumn 4, Issue 17, 2006, Pages 3252-3258

The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase

(6) Wang, Xiaowei a Lou, Qinghua a Guo, Ying b Xu, Yang a Zhang, Zhili a Liu, Junyi a

a PEKING UNIVERSITY HEALTH SCIENCE CENTER (China)

b PEKING UNIVERSITY (China)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; ENZYME INHIBITION; REACTION KINETICS; SYNTHESIS (CHEMICAL); UREA; VIRUSES;

BIOLOGICAL ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS (HIV); NON NUCLEOSIDE INHIBITORS; PYRINIDINE;

ORGANIC COMPOUNDS;

6 BENZYL 1 (ETHOXYMETHYL) 5 ISOPROPYLURACIL; 6-BENZYL-1-(ETHOXYMETHYL)-5-ISOPROPYLURACIL; 9 PHENYLCYCLOHEPTA(D)PYRIMIDINE 2,4 DIONE; 9-PHENYLCYCLOHEPTA(D)PYRIMIDINE-2,4-DIONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYCLOHEPTANE DERIVATIVE; DRUG DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; URACIL;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOHEPTANES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIMIDINES; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; URACIL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33747888390 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b607972p Document Type: Article

Times cited : (20)

References (42)

1
- 0024999452
- S. P. Goff J. Acquired Immune Defic. Syndr. 1990 3 817 831
- (1990) J. Acquired Immune Defic. Syndr. , vol.3 , pp. 817-831
- Goff, S.P.¹

2
- 0023091963
- H. Mitsuya S. Broder Nature 1987 325 773 778
- (1987) Nature , vol.325 , pp. 773-778
- Mitsuya, H.¹ Broder, S.²

3
- 0026620579
- M. Baba Z. Debyser S. Shigeta E. D. Clercq Drugs Future 1992 17 891
- (1992) Drugs Future , vol.17 , pp. 891
- Baba, M.¹ Debyser, Z.² Shigeta, S.³ Clercq, E.D.⁴

4
- 0022996630
- P. A. Furman J. A. Fyfe M. H. St. Clair K. J. Weinhold, J. L. Rideout G. A. Freeman S. N. Lehrman D. P. Bolognesi S. Broder H. Mitsuya D. W. Barry Proc. Natl. Acad. Sci. U. S. A. 1986 83 8333 8337
- (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 8333-8337
- Furman, P.A.¹ Fyfe, J.A.² St. Clair, M.H.³ Weinhold, K.J.⁴ Rideout, J.L.⁵ Freeman, G.A.⁶ Lehrman, S.N.⁷ Bolognesi, D.P.⁸ Broder, S.⁹ Mitsuya, H.¹⁰ Barry, D.W.¹¹

5
- 0023475103
- M. H. St. Clair C. A. Richards T. Spector K. J. Weinhold V. H. Miller A. J. Langlois P. A. Furman Antimicrob. Agents Chemother. 1987 31 1972
- (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 1972
- St. Clair, M.H.¹ Richards, C.A.² Spector, T.³ Weinhold, K.J.⁴ Miller, V.H.⁵ Langlois, A.J.⁶ Furman, P.A.⁷

6
- 0024349612
- R. Yachoan H. Mitsuya R. V. Thomas J. M. Pioda N. R. Hartman C. F. Perno K. S. Marczky J. P. Allain D. G. Johns S. Broder Science 1989 245 412 415
- (1989) Science , vol.245 , pp. 412-415
- Yachoan, R.¹ Mitsuya, H.² Thomas, R.V.³ Pioda, J.M.⁴ Hartman, N.R.⁵ Perno, C.F.⁶ Marczky, K.S.⁷ Allain, J.P.⁸ Johns, D.G.⁹ Broder, S.¹⁰

7
- 0001707601
- H. Mitsuya K. J. Weinhold P. A. Furman M. H. St. Clair S. Nusinoff-Lehrman R. C. Gallo D. Bolognesi D. W. Barry Proc. Natl. Acad. Sci. U. S. A. 1985 82 7096 7100
- (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 7096-7100
- Mitsuya, H.¹ Weinhold, K.J.² Furman, P.A.³ St. Clair, M.H.⁴ Nusinoff-Lehrman, S.⁵ Gallo, R.C.⁶ Bolognesi, D.⁷ Barry, D.W.⁸

8
- 0001587762
- H. Mitsuya S. Broder Proc. Natl. Acad. Sci. U. S. A. 1986 83 1911 1915
- (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 1911-1915
- Mitsuya, H.¹ Broder, S.²

9
- 0023196616
- T. S. Lin F. R. Schinazi W. H. Prusoff Biochem. Pharmacol. 1987 36 2713 2718
- (1987) Biochem. Pharmacol. , vol.36 , pp. 2713-2718
- Lin, T.S.¹ Schinazi, F.R.² Prusoff, W.H.³

10
- 0025679303
- V. J. Merluzzi K. D. Hargrave S. Hattox J. Adams A. S. Rosenthal R. Faanes R. J. Eckner R. A. Koup J. L. Sullivan Science 1990 250 1411 1413
- (1990) Science , vol.250 , pp. 1411-1413
- Merluzzi, V.J.¹ Hargrave, K.D.² Hattox, S.³ Adams, J.⁴ Rosenthal, A.S.⁵ Faanes, R.⁶ Eckner, R.J.⁷ Koup, R.A.⁸ Sullivan, J.L.⁹

11
- 0025014499
- R. Pauwels K. Andries J. Desmyter D. K. Schols M. J. Kukla H. J. Bresdin A. Raemaekers J. Von Gelder R. Woestenborghs J. Heyrants K. Schellekens E. D. Clercq P. A. Janssen Nature 1990 343 470 474
- (1990) Nature , vol.343 , pp. 470-474
- Pauwels, R.¹ Andries, K.² Desmyter, J.³ Schols, D.K.⁴ Kukla, M.J.⁵ Bresdin, H.J.⁶ Raemaekers, A.⁷ Von Gelder, J.⁸ Woestenborghs, R.⁹ Heyrants, J.¹⁰ Schellekens, K.¹¹ Clercq, E.D.¹² Janssen, P.A.¹³

12
- 0024408374
- T. Miyasaka H. Tanaka M. Baba H. Hayakawa R. T. Walker J. Balzarini E. D. Clercq J. Med. Chem. 1989 32 2507 2509
- (1989) J. Med. Chem. , vol.32 , pp. 2507-2509
- Miyasaka, T.¹ Tanaka, H.² Baba, M.³ Hayakawa, H.⁴ Walker, R.T.⁵ Balzarini, J.⁶ Clercq, E.D.⁷

13
- 0025996983
- D. J. Romero M. Busso C. K. Tan F. Reusser J. R. Palmer S. M. Poppe P. A. Aristoff K. M. Downey L. Resnik W. G. Tarpley; Proc. Natl. Acad. Sci. U. S. A. 1991 88 8806 8810
- (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 8806-8810
- Romero, D.J.¹ Busso, M.² Tan, C.K.³ Reusser, F.⁴ Palmer, J.R.⁵ Poppe, S.M.⁶ Aristoff, P.A.⁷ Downey, K.M.⁸ Resnik, L.⁹ Tarpley, W.G.¹⁰

14
- 0026077832
- J. H. Nunberg W. A. Schleif E. J. Boots J. A. O'Brien J. C. Quintero J. M. Hoffman E. A. Emini M. E. Goldman J. Virol. 1991 65 4887 4892
- (1991) J. Virol. , vol.65 , pp. 4887-4892
- Nunberg, J.H.¹ Schleif, W.A.² Boots, E.J.³ O'Brien, J.A.⁴ Quintero, J.C.⁵ Hoffman, J.M.⁶ Emini, E.A.⁷ Goldman, M.E.⁸

15
- 0026579394
- J. W. Mellors G. E. Dutschman G. J. Im E. Tramontano S. R. Winkler Y. C. Cheng Mol. Pharmacol. 1992 41 446 451
- (1992) Mol. Pharmacol. , vol.41 , pp. 446-451
- Mellors, J.W.¹ Dutschman, G.E.² Im, G.J.³ Tramontano, E.⁴ Winkler, S.R.⁵ Cheng, Y.C.⁶

16
- 0027472841
- J. W. Mellors G. J. Im E. Tramontano S. R. Winkler D. J. Medina G. E. Dutschman H. Z. Bazmi G. Piras C. J. Gonzalez Y. C. Cheng Mol. Pharmacol. 1993 43 11 16
- (1993) Mol. Pharmacol. , vol.43 , pp. 11-16
- Mellors, J.W.¹ Im, G.J.² Tramontano, E.³ Winkler, S.R.⁴ Medina, D.J.⁵ Dutschman, G.E.⁶ Bazmi, H.Z.⁷ Piras, G.⁸ Gonzalez, C.J.⁹ Cheng, Y.C.¹⁰

17
- 0024832408
- M. Baba H. Tanaka E. D. Clercq R. Pauwels J. Balzarini D. Schols H. Nakashima C. F. Perno R. T. Walker T. Miyasaka Biochem. Biophys. Res. Commun. 1989 165 1375 1381
- (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 1375-1381
- Baba, M.¹ Tanaka, H.² Clercq, E.D.³ Pauwels, R.⁴ Balzarini, J.⁵ Schols, D.⁶ Nakashima, H.⁷ Perno, C.F.⁸ Walker, R.T.⁹ Miyasaka, T.¹⁰

18
- 0024408374
- T. Miyasaka H. Tanaka M. Baba H. Hayakawa R. T. Walker J. Balzarini E. D. Clercq J. Med. Chem. 1989 32 2507 2509
- (1989) J. Med. Chem. , vol.32 , pp. 2507-2509
- Miyasaka, T.¹ Tanaka, H.² Baba, M.³ Hayakawa, H.⁴ Walker, R.T.⁵ Balzarini, J.⁶ Clercq, E.D.⁷

19
- 0027436898
- S. Yuasa Y. Sadakata H. Takashima K. Sekiya N. Inouye M. Ubasawa M. Baba Mol. Pharmacol. 1993 44 895 900
- (1993) Mol. Pharmacol. , vol.44 , pp. 895-900
- Yuasa, S.¹ Sadakata, Y.² Takashima, H.³ Sekiya, K.⁴ Inouye, N.⁵ Ubasawa, M.⁶ Baba, M.⁷

20
- 0028329454
- M. Baba S. Shigeta S. Yuasa H. Takashima K. Sekiya M. Ubasawa H. Tanaka T. Miyasaka R. T. Walker E. D. Clercq Antimicrob. Agents Chemother. 1994 38 688 692
- (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 688-692
- Baba, M.¹ Shigeta, S.² Yuasa, S.³ Takashima, H.⁴ Sekiya, K.⁵ Ubasawa, M.⁶ Tanaka, H.⁷ Miyasaka, T.⁸ Walker, R.T.⁹ Clercq, E.D.¹⁰

21
- 0029096567
- H. Tanaka H. Takashima M. Ubasawa K. Sekiya N. Inouye M. Baba S. Shigeta R. T. Walker E. D. Clercq T. Miyasaka J. Med. Chem. 1995 38 2860 2865
- (1995) J. Med. Chem. , vol.38 , pp. 2860-2865
- Tanaka, H.¹ Takashima, H.² Ubasawa, M.³ Sekiya, K.⁴ Inouye, N.⁵ Baba, M.⁶ Shigeta, S.⁷ Walker, R.T.⁸ Clercq, E.D.⁹ Miyasaka, T.¹⁰

22
- 0029976422
- A. L. Hopkins J. Ren R. M. Esnouf B. E. Willcox E. Y. Jones C. Ross T. Miyasaka R. T. Walker H. Tanaka D. K. Stammers D. I. Stuart J. Med. Chem. 1996 39 1589 1600
- (1996) J. Med. Chem. , vol.39 , pp. 1589-1600
- Hopkins, A.L.¹ Ren, J.² Esnouf, R.M.³ Willcox, B.E.⁴ Jones, E.Y.⁵ Ross, C.⁶ Miyasaka, T.⁷ Walker, R.T.⁸ Tanaka, H.⁹ Stammers, D.K.¹⁰ Stuart, D.I.¹¹

23
- 33747875758
- Press statement from Triangle Pharmaceuticals Inc., 17 January 2002
- R. T. Walker E. D. Clercq Nucleosides Nucleotides 1995 14 575 583
- (1995) Nucleosides Nucleotides , vol.14 , pp. 575-583
- Walker, R.T.¹ Clercq, E.D.²

24
- 33747876352
- C. Catalanotti B. Morelli E. Novellino Curr. Pharm. Des. 2002 8 615 657
- (2002) Curr. Pharm. Des. , vol.8 , pp. 615-657
- Catalanotti, C.¹ Morelli, B.² Novellino, E.³

25
- 0029593364
- E. D. Clercq J. Balzarini Farmaco 1995 50 735 747
- (1995) Farmaco , vol.50 , pp. 735-747
- Clercq, E.D.¹ Balzarini, J.²

26
- 0032437454
- E. D. Clercq Antiviral Res. 1998 38 153 179
- (1998) Antiviral Res. , vol.38 , pp. 153-179
- Clercq, E.D.¹

27
- 0032918170
- E. D. Clercq Farmaco 1999 54 26 45
- (1999) Farmaco , vol.54 , pp. 26-45
- Clercq, E.D.¹

28
- 0028947588
- J. Ren R. Esnouf E. Garman D. Somers C. Ross I. Kirby J. Keeling G. Darby Y. Jones D. Stuart D. Stammers Nat. Struct. Biol. 1995 2 293 302
- (1995) Nat. Struct. Biol. , vol.2 , pp. 293-302
- Ren, J.¹ Esnouf, R.² Garman, E.³ Somers, D.⁴ Ross, C.⁵ Kirby, I.⁶ Keeling, J.⁷ Darby, G.⁸ Jones, Y.⁹ Stuart, D.¹⁰ Stammers, D.¹¹

29
- 0029644484
- J. Ding K. Das C. Tantillo W. Zhang A. D. Clark S. J. Jessen X. Lu Y. Hsiou A. Jacobo-Molina K. Andries R. Pauwels H. Moereels L. Koymans P. A. Janseen R. H. Smith M. Kroeger Koepke C. J. Michejda S. H. Hughes E. Arnold Structure 1995 3 365 379
- (1995) Structure , vol.3 , pp. 365-379
- Ding, J.¹ Das, K.² Tantillo, C.³ Zhang, W.⁴ Clark, A.D.⁵ Jessen, S.J.⁶ Lu, X.⁷ Hsiou, Y.⁸ Jacobo-Molina, A.⁹ Andries, K.¹⁰ Pauwels, R.¹¹ Moereels, H.¹² Koymans, L.¹³ Janseen, P.A.¹⁴ Smith, R.H.¹⁵ Kroeger Koepke, M.¹⁶ Michejda, C.J.¹⁷ Hughes, S.H.¹⁸ Arnold, E.¹⁹

30
- 0029075207
- J. Ding K. Das H. Moereels L. Koymans K. Andries P. A. Janssen S. H. Hughes E. Arnold Nat. Struct. Biol. 1995 2 407 415
- (1995) Nat. Struct. Biol. , vol.2 , pp. 407-415
- Ding, J.¹ Das, K.² Moereels, H.³ Koymans, L.⁴ Andries, K.⁵ Janssen, P.A.⁶ Hughes, S.H.⁷ Arnold, E.⁸

31
- 0029645409
- J. Ren R. Esnouf A. Hopkins C. Ross Y. Jones D. Stammers D. Stuart Structure 1995 3 915 926
- (1995) Structure , vol.3 , pp. 915-926
- Ren, J.¹ Esnouf, R.² Hopkins, A.³ Ross, C.⁴ Jones, Y.⁵ Stammers, D.⁶ Stuart, D.⁷

32
- 0030935265
- R. M. Esnouf J. Ren A. L. Hopkins C. K. Ross E. Y. Jones D. K. Stammers D. I. Stuart Proc. Natl. Acad. Sci. U. S. A. 1997 94 3984 3989
- (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 3984-3989
- Esnouf, R.M.¹ Ren, J.² Hopkins, A.L.³ Ross, C.K.⁴ Jones, E.Y.⁵ Stammers, D.K.⁶ Stuart, D.I.⁷

33
- 17544387814
- R. M. Esnouf D. I. Stuart E. D. Clercq E. Schwartz J. Balzarini Biochem. Biophys. Res. Commun. 1997 234 458 464
- (1997) Biochem. Biophys. Res. Commun. , vol.234 , pp. 458-464
- Esnouf, R.M.¹ Stuart, D.I.² Clercq, E.D.³ Schwartz, E.⁴ Balzarini, J.⁵

34
- 0034699706
- J. S. Larsen L. Christensen G. Ludvig P. T. Jørgensen E. B. Pedersen C. Nielsen J. Chem. Soc., Perkin Trans. 1 2000 3035 3038
- (2000) J. Chem. Soc., Perkin Trans. 1 , pp. 3035-3038
- Larsen, J.S.¹ Christensen, L.² Ludvig, G.³ Jørgensen, P.T.⁴ Pedersen, E.B.⁵ Nielsen, C.⁶

35
- 0041882244
- F. D. Therkelsen A. L. L. Hansen E. B. Pedersen C. Nielsen Org. Biomol. Chem. 2003 1 2908
- (2003) Org. Biomol. Chem. , vol.1 , pp. 2908
- Therkelsen, F.D.¹ Hansen, A.L.L.² Pedersen, E.B.³ Nielsen, C.⁴

36
- 0033617594
- M. Macchia G. Antonelli A. Balsamo S. Barontini F. Calvani D. Gentili A. Martinelli A. Rossello O. Turriziani R. Tesoro Farmaco 1999 54 242 247
- (1999) Farmaco , vol.54 , pp. 242-247
- MacChia, M.¹ Antonelli, G.² Balsamo, A.³ Barontini, S.⁴ Calvani, F.⁵ Gentili, D.⁶ Martinelli, A.⁷ Rossello, A.⁸ Turriziani, O.⁹ Tesoro, R.¹⁰

37
- 11644261806
- G. M. Morris D. S. Goodsell R. S. Halliday R. Huey W. E. Hart R. K. Belew A. J. Olson J. Comput. Chem. 1998 19 1639
- (1998) J. Comput. Chem. , vol.19 , pp. 1639
- Morris, G.M.¹ Goodsell, D.S.² Halliday, R.S.³ Huey, R.⁴ Hart, W.E.⁵ Belew, R.K.⁶ Olson, A.J.⁷

38
- 0033524008
- A. L. Hopkins J. Ren H. Tanaka M. Baba M. Okamato D. I. Stuart D. K. Stammers J. Med. Chem. 1999 42 4500
- (1999) J. Med. Chem. , vol.42 , pp. 4500
- Hopkins, A.L.¹ Ren, J.² Tanaka, H.³ Baba, M.⁴ Okamato, M.⁵ Stuart, D.I.⁶ Stammers, D.K.⁷

39
- 33747889114
- Gutsche Johnson Org. Synth. 1963 Coll. Vol. IV 781
- (1963) Org. Synth. , vol.4 , pp. 781
- Gutsche, J.¹

40
- 0002437255
- A. P. Krapcho J. Diamanti C. Cayen R. Bingham Org. Synth. 1967 Coll. Vol. V 20
- (1967) Org. Synth. , vol.5 , pp. 20
- Krapcho, A.P.¹ Diamanti, J.² Cayen, C.³ Bingham, R.⁴

41
- 0029111877
- K. Danel E. Larsen E. B. Pedersen Synthesis 1995 934 936
- (1995) Synthesis , pp. 934-936
- Danel, K.¹ Larsen, E.² Pedersen, E.B.³

42
- 3643122145
- C. D. Gutsche H. E. Johnson; J. Am. Chem. Soc. 1955 77 109 112
- (1955) J. Am. Chem. Soc. , vol.77 , pp. 109-112
- Gutsche, C.D.¹ Johnson, H.E.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.