Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells

Journal of Pathology

Volumn 210, Issue 1, 2006, Pages 75-84

  Ikeda, J I ^a   Morii, E ^a   Kimura, H ^a   Tomita, Y ^a   Takakuwa, T ^a   Hasegawa, J I ^a   Kim, Y K ^a   Miyoshi, Y ^a   Noguchi, S ^a   Nishida, T ^a   Aozasa, K ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer; CDCP1; Clinical samples; Methylation; Transcriptional regulation

Indexed keywords

KI 67 ANTIGEN; MEMBRANE PROTEIN; PROTEIN CDCP1; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN K 562; CELL STRAIN MCF 7; CELL STRAIN U937; CLINICAL ARTICLE; CORRELATION ANALYSIS; CPG ISLAND; DNA SEQUENCE; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN MOTIF; QUANTITATIVE ANALYSIS; RAJI CELL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; ANTIGENS, CD; ANTIGENS, NEOPLASM; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CPG ISLANDS; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LEUKEMIA; LYMPHOMA; METHYLATION; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 33747886870     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2026     Document Type: Article

References (18)

1. Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 2001;20:4402-4408.
2. Hooper JD, Zijlstra A, Aimes RT, Liang H, Claassen GF, Tarin D, et al. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 2003;22:1783-1794.
3. Conze T, Lammers R, Kuci S, Scherl-Mostageer M, Schweifer N, Kanz L, et al, CDCP1 is a novel marker for hematopoietic stem cells. Ann NY Acad Sci 2003;996:222-226.
4. Buhring H-J, Kuci S, Conze T, Rathke G, Bartolovic K, Grunebach F, et al. CDCP1 identifies a broad spectrum of normal and malignant stem/ progenitor cell subsets of hematopoietic and nonhematopoietic origin. Stem Cells 2004;22:334-343.
5. Brown TA, Yang TM, Zaitsevskaia T, Xia Y, Dunn CA, Sigle RO, et al. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p8O/gp14O/CUB domain-containing protein 1 in epithelia. J Biol Chem 2004;279:14772-14783.
6. Benes CH, Wu N, Elia AEH, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKC-delta is a phosphotyrosine binding domain. Cell 2005;121:271-280.
7. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111.
8. Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902.
9. Jordan CT. Cancer stem cell biology: from leukemia to solid tumors. Curr Opin Cell Biol 2004;16:708-712.
10. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828.
11. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100:3983-3988.
12. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genetics 2002;3:415-428.
13. Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004;4:143-153.
14. Sutherland KD, Lindeman GJ, Choong DY, Wittlin S, Brentzell L, Phillips W, et al. Differential hypermethylation of SOCS genes in ovarian and breast carcinoma. Oncogene 2004;23:7726-7733.
15. Morii E, Oboki K. MITF is necessary for generation of prostaglandin D2 in mouse mast cells. J Biol Chem 2004;279:48923-48929.
16. Alleman WG, Tabios RL, Chandramouli GV, Aprelikova ON, Torres-Cabala C, Mendoza A, et al. The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2′-deoxycytidine. Clin Cancer Res 2004;10:7011-7021.
17. Frigola J, Ribas M, Risques RA, Peinado MA. Methylome profiling of cancer cells by amplification of inter-methylated sites. Nucleic Acids Res 2002;30:e28.
18. Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hpx gene silencing. Mol Cell 2005;20:845-854.