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Volumn 93, Issue 1, 2006, Pages 22-33

A dermatotoxicokinetic model of human exposures to jet fuel

Author keywords

Exposure assessment; Jet fuel; Skin; Toxicokinetics

Indexed keywords

ALIPHATIC COMPOUND; AROMATIC COMPOUND; FUEL;

EID: 33747877961     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl048     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0026170520 scopus 로고
    • Physiological modelling of organic compounds
    • Andersen, M. E. (1991). Physiological modelling of organic compounds. Ann. Occup. Hyg. 35, 309-321.
    • (1991) Ann. Occup. Hyg. , vol.35 , pp. 309-321
    • Andersen, M.E.1
  • 2
    • 0035068731 scopus 로고    scopus 로고
    • Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats
    • Andersen, M. E., Sarangapani, R., Reitz, R. H., Gallavan, R. H., Dobrev, I. D., and Plotzke, K. P. (2001). Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 60, 214-231.
    • (2001) Toxicol. Sci. , vol.60 , pp. 214-231
    • Andersen, M.E.1    Sarangapani, R.2    Reitz, R.H.3    Gallavan, R.H.4    Dobrev, I.D.5    Plotzke, K.P.6
  • 3
    • 0003735203 scopus 로고
    • Toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene
    • Agency for Toxic Substances and Disease Registry. U.S. Department of Health and Human Services, U.S. Public Health Service, Atlanta, GA
    • Agency for Toxic Substances and Disease Registry (1995). Toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene. U.S. Department of Health and Human Services, U.S. Public Health Service, Atlanta, GA.
    • (1995)
  • 4
    • 0034616620 scopus 로고    scopus 로고
    • Modeling of diffusion and concurrent metabolism in cutaneous tissue
    • Boderke, P., Schittkowski, K.,Wolf, M., and Merkle, H. P. (2000). Modeling of diffusion and concurrent metabolism in cutaneous tissue. J. Theor. Biol. 204, 393-407.
    • (2000) J. Theor. Biol. , vol.204 , pp. 393-407
    • Boderke, P.1    Schittkowski, K.2    Wolf, M.3    Merkle, H.P.4
  • 5
    • 0004130489 scopus 로고    scopus 로고
    • Percutaneous absorption drugs - Cosmetics - Mechanisms - Methodology
    • Dekker, New York
    • Bronaugh, R. L., and Maibach, H. I. (1999). Percutaneous absorption drugs - cosmetics - mechanisms - methodology. Dekker, New York.
    • (1999)
    • Bronaugh, R.L.1    Maibach, H.I.2
  • 6
    • 0022922042 scopus 로고
    • Naphthalene metabolism by human lung microsomal enzymes
    • Buckpitt, A., and Bahnson, L. (1986). Naphthalene metabolism by human lung microsomal enzymes. Toxicology 41, 333-341.
    • (1986) Toxicology , vol.41 , pp. 333-341
    • Buckpitt, A.1    Bahnson, L.2
  • 7
    • 0034131529 scopus 로고    scopus 로고
    • The use of solid-phase microextraction in conjunction with a benchtop quadrupole mass spectrometer for the analysis of volatile organic compounds in human blood at the low parts-per-trillion level
    • Cardinali, F. L., Ashley, D. L.,Wooten, J. V., McCraw, J. M., and Lemire, S.W. (2000). The use of solid-phase microextraction in conjunction with a benchtop quadrupole mass spectrometer for the analysis of volatile organic compounds in human blood at the low parts-per-trillion level. J. Chromatogr. Sci. 38, 49-54.
    • (2000) J. Chromatogr. Sci. , vol.38 , pp. 49-54
    • Cardinali, F.L.1    Ashley, D.L.2    Wooten, J.V.3    McCraw, J.M.4    Lemire, S.W.5
  • 8
    • 26644433695 scopus 로고    scopus 로고
    • Dermal exposure to jet fuel (JP-8) in US Air Force personnel
    • Chao,Y. C., Gibson, R. L., and Nylander-French, L. A. (2005). Dermal exposure to jet fuel (JP-8) in US Air Force personnel. Ann. Occup. Hyg. 49, 639-645.
    • (2005) Ann. Occup. Hyg. , vol.49 , pp. 639-645
    • Chao, Y.C.1    Gibson, R.L.2    Nylander-French, L.A.3
  • 9
    • 32044474465 scopus 로고    scopus 로고
    • Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers
    • Chao, Y. C., Kupper, L. L., Serdar, B., Egeghy, P. P., Rappaport, S. M., and Nylander-French, L. A. (2006). Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers. Environ. Health Perspect. 114, 182-185.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 182-185
    • Chao, Y.C.1    Kupper, L.L.2    Serdar, B.3    Egeghy, P.P.4    Rappaport, S.M.5    Nylander-French, L.A.6
  • 10
    • 1642373807 scopus 로고    scopus 로고
    • Determination of keratin protein in a tape-stripped skin sample from jet fuel exposed skin
    • Chao, Y. C., and Nylander-French, L. A. (2004). Determination of keratin protein in a tape-stripped skin sample from jet fuel exposed skin. Ann. Occup. Hyg. 48, 65-73.
    • (2004) Ann. Occup. Hyg. , vol.48 , pp. 65-73
    • Chao, Y.C.1    Nylander-French, L.A.2
  • 11
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies, B., and Morris, T. (1993). Physiological parameters in laboratory animals and humans. Pharm. Res. 10, 1093-1095.
    • (1993) Pharm. Res. , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 12
    • 0027755236 scopus 로고
    • Dermal exposure assessment technique
    • Fenske, R. A. (1993). Dermal exposure assessment technique. Ann. Occup. Hyg. 37, 687-706.
    • (1993) Ann. Occup. Hyg. , vol.37 , pp. 687-706
    • Fenske, R.A.1
  • 14
    • 0242290769 scopus 로고    scopus 로고
    • Steady-state flux and lag time in the stratum corneum lipid pathway: Results from finite element models
    • Frasch, H. F., and Barbero, A. M. (2003). Steady-state flux and lag time in the stratum corneum lipid pathway: Results from finite element models. J. Pharm. Sci. 92, 2196-2207.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 2196-2207
    • Frasch, H.F.1    Barbero, A.M.2
  • 15
    • 43949152886 scopus 로고
    • Global optimization of statistical functions with simulated annealing
    • Goffe, W. L., Ferrier, G. D., and Rojers, J. (1994). Global optimization of statistical functions with simulated annealing. J. Econom. 60, 65-99.
    • (1994) J. Econom. , vol.60 , pp. 65-99
    • Goffe, W.L.1    Ferrier, G.D.2    Rojers, J.3
  • 16
  • 17
    • 17444414230 scopus 로고    scopus 로고
    • Estimation of the relative stratum corneum amount removed by tape stripping
    • Jacobi, U., Weigmann, H. J., Ulrich, J., Sterry, W., and Lademann, J. (2005). Estimation of the relative stratum corneum amount removed by tape stripping. Skin Res. Technol. 11, 91-96.
    • (2005) Skin Res. Technol. , vol.11 , pp. 91-96
    • Jacobi, U.1    Weigmann, H.J.2    Ulrich, J.3    Sterry, W.4    Lademann, J.5
  • 18
    • 33746683271 scopus 로고    scopus 로고
    • Dermal absorption and penetration of jet fuel components in humans
    • Kim, D., Andersen, M. E., and Nylander-French, L. A. (2006). Dermal absorption and penetration of jet fuel components in humans. Toxicol. Lett. 165, 11-21.
    • (2006) Toxicol. Lett. , vol.165 , pp. 11-21
    • Kim, D.1    Andersen, M.E.2    Nylander-French, L.A.3
  • 20
    • 2942609098 scopus 로고    scopus 로고
    • PKQuest: A general physiologically based pharmacokinetic model. Introduction and application to propranolol
    • Levitt, D. G. (2002). PKQuest: A general physiologically based pharmacokinetic model. Introduction and application to propranolol. BMC Clin. Pharmacol. 2, 5.
    • (2002) BMC Clin. Pharmacol. , vol.2 , pp. 5
    • Levitt, D.G.1
  • 21
    • 5344238200 scopus 로고    scopus 로고
    • Bioequivalence determination of topical ketoprofen using a dermatopharmacokinetic approach and excised skin penetration
    • Loden, M., Akerstrom, U., Lindahl, K., and Berne, B. (2004). Bioequivalence determination of topical ketoprofen using a dermatopharmacokinetic approach and excised skin penetration. Int. J. Pharm. 284, 23-30.
    • (2004) Int. J. Pharm. , vol.284 , pp. 23-30
    • Loden, M.1    Akerstrom, U.2    Lindahl, K.3    Berne, B.4
  • 22
    • 8344232534 scopus 로고    scopus 로고
    • Stratum corneum adhesive tape stripping: Influence of anatomical site, application pressure, duration and removal
    • Loffler, H., Dreher, F., and Maibach, H. I. (2004). Stratum corneum adhesive tape stripping: Influence of anatomical site, application pressure, duration and removal. Br. J. Dermatol. 151, 746-752.
    • (2004) Br. J. Dermatol. , vol.151 , pp. 746-752
    • Loffler, H.1    Dreher, F.2    Maibach, H.I.3
  • 23
    • 0042121374 scopus 로고    scopus 로고
    • Barrier function of the skin: "La raison d'etre"' of the epidermis
    • Madison, K. C. (2003). Barrier function of the skin: "la raison d'etre"' of the epidermis. J. Invest. Dermatol. 121, 231-241.
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 231-241
    • Madison, K.C.1
  • 24
    • 3543133671 scopus 로고    scopus 로고
    • The stratum corneum barrier: The final frontier
    • Marks, R. (2004). The stratum corneum barrier: The final frontier. J. Nutr. 134, 2017S-2021S.
    • (2004) J. Nutr. , vol.134
    • Marks, R.1
  • 25
    • 0035153424 scopus 로고    scopus 로고
    • Pharmacokinetic models of dermal absorption
    • McCarley, K. D., and Bunge, A. L. (2001). Pharmacokinetic models of dermal absorption. J. Pharm. Sci. 90, 1699-1719.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1699-1719
    • McCarley, K.D.1    Bunge, A.L.2
  • 26
    • 0036023493 scopus 로고    scopus 로고
    • Methods for assessing risks of dermal exposures in the workplace
    • McDougal, J. N., and Boeniger, M. F. (2002). Methods for assessing risks of dermal exposures in the workplace. Crit. Rev. Toxicol. 32, 291-327.
    • (2002) Crit. Rev. Toxicol. , vol.32 , pp. 291-327
    • McDougal, J.N.1    Boeniger, M.F.2
  • 27
    • 0034079915 scopus 로고    scopus 로고
    • Assessment of skin absorption and penetration of JP-8 jet fuel and its components
    • McDougal, J. N., Pollard, D. L., Weisman, W., Garrett, C. M., and Miller, T. E. (2000). Assessment of skin absorption and penetration of JP-8 jet fuel and its components. Toxicol. Sci. 55, 247-255.
    • (2000) Toxicol. Sci. , vol.55 , pp. 247-255
    • McDougal, J.N.1    Pollard, D.L.2    Weisman, W.3    Garrett, C.M.4    Miller, T.E.5
  • 28
    • 0037041156 scopus 로고    scopus 로고
    • Assessment of dermal absorption and penetration of components of a fuel mixture (JP-8)
    • McDougal, J. N., and Robinson, P. J. (2002). Assessment of dermal absorption and penetration of components of a fuel mixture (JP-8). Sci. Total Environ. 288, 23-30.
    • (2002) Sci. Total Environ. , vol.288 , pp. 23-30
    • McDougal, J.N.1    Robinson, P.J.2
  • 29
    • 0037426686 scopus 로고    scopus 로고
    • Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways
    • Mitragotri, S. (2003). Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways. J. Control Release 86, 69-92.
    • (2003) J. Control Release , vol.86 , pp. 69-92
    • Mitragotri, S.1
  • 30
    • 1942517428 scopus 로고    scopus 로고
    • Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems
    • Muhammad, F., Brooks, J. D., and Riviere, J. E. (2004). Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems. Toxicol. Lett. 150, 351-365.
    • (2004) Toxicol. Lett. , vol.150 , pp. 351-365
    • Muhammad, F.1    Brooks, J.D.2    Riviere, J.E.3
  • 31
    • 0034550278 scopus 로고    scopus 로고
    • A tape-stripping method for measuring dermal exposure to multifunctional acrylates
    • Nylander-French, L. A. (2000). A tape-stripping method for measuring dermal exposure to multifunctional acrylates. Ann. Occup. Hyg. 44, 645-651.
    • (2000) Ann. Occup. Hyg. , vol.44 , pp. 645-651
    • Nylander-French, L.A.1
  • 32
    • 1642274503 scopus 로고    scopus 로고
    • Occupational dermal exposure assessment
    • In (R. Harrison, Ed.). John Wiley & Sons, Inc, New York
    • Nylander-French, L. A. (2003). Occupational dermal exposure assessment. In Patty's Industrial Hygiene (R. Harrison, Ed.). John Wiley & Sons, Inc, New York.
    • (2003) Patty's Industrial Hygiene
    • Nylander-French, L.A.1
  • 33
    • 4544298810 scopus 로고    scopus 로고
    • Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellant-8
    • Perleberg, U. R., Keys, D. A., and Fisher, J. W. (2004). Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellant-8. Inhal. Toxicol. 16, 771-783.
    • (2004) Inhal. Toxicol. , vol.16 , pp. 771-783
    • Perleberg, U.R.1    Keys, D.A.2    Fisher, J.W.3
  • 34
    • 0036072857 scopus 로고    scopus 로고
    • Comparison of skin stripping, in vitro release, and skin blanching response methods to measure dose response and similarity of triamcinolone acetonide cream strengths from two manufactured sources
    • Pershing, L. K., Bakhtian, S., Poncelet, C. E., Corlett, J. L., and Shah, V. P. (2002). Comparison of skin stripping, in vitro release, and skin blanching response methods to measure dose response and similarity of triamcinolone acetonide cream strengths from two manufactured sources. J. Pharm. Sci. 91, 1312-1323.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1312-1323
    • Pershing, L.K.1    Bakhtian, S.2    Poncelet, C.E.3    Corlett, J.L.4    Shah, V.P.5
  • 35
    • 0038623641 scopus 로고    scopus 로고
    • Assessment of dermatopharmacokinetic approach in the bioequivalence determination of topical tretinoin gel products
    • Pershing, L. K., Nelson, J. L., Corlett, J. L., Shrivastava, S. P., Hare, D. B., and Shah, V. P. (2003). Assessment of dermatopharmacokinetic approach in the bioequivalence determination of topical tretinoin gel products. J. Am. Acad. Dermatol. 48, 740-751.
    • (2003) J. Am. Acad. Dermatol. , vol.48 , pp. 740-751
    • Pershing, L.K.1    Nelson, J.L.2    Corlett, J.L.3    Shrivastava, S.P.4    Hare, D.B.5    Shah, V.P.6
  • 38
    • 0037140387 scopus 로고    scopus 로고
    • Skin absorption and human risk assessment
    • Poet, T. S., and McDougal, J. N. (2002). Skin absorption and human risk assessment. Chem. Biol. Interact. 140, 19-34.
    • (2002) Chem. Biol. Interact. , vol.140 , pp. 19-34
    • Poet, T.S.1    McDougal, J.N.2
  • 39
    • 0033625040 scopus 로고    scopus 로고
    • Dermatoxicokinetic modeling of p-nitrophenol and its conjugation metabolite in swine following topical and intravenous administration
    • Qiao, G. L., Chang, S. K., Brooks, J. D., and Riviere, J. E. (2000). Dermatoxicokinetic modeling of p-nitrophenol and its conjugation metabolite in swine following topical and intravenous administration. Toxicol. Sci. 54, 284-294.
    • (2000) Toxicol. Sci. , vol.54 , pp. 284-294
    • Qiao, G.L.1    Chang, S.K.2    Brooks, J.D.3    Riviere, J.E.4
  • 40
    • 0036198814 scopus 로고    scopus 로고
    • Determining dermal absorption parameters in vivo from tape strip data
    • Reddy, M. B., Stinchcomb, A. L., Guy, R. H., and Bunge, A. L. (2002). Determining dermal absorption parameters in vivo from tape strip data. Pharm. Res. 19, 292-298.
    • (2002) Pharm. Res. , vol.19 , pp. 292-298
    • Reddy, M.B.1    Stinchcomb, A.L.2    Guy, R.H.3    Bunge, A.L.4
  • 41
    • 0001727688 scopus 로고
    • Identification in parametric models
    • Rothenberg, T. J. (1971). Identification in parametric models. Econometrica 39, 577-591.
    • (1971) Econometrica , vol.39 , pp. 577-591
    • Rothenberg, T.J.1
  • 42
    • 0036133254 scopus 로고    scopus 로고
    • Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke
    • Rustemeier, K., Stabbert, R., Haussmann, H. J., Roemer, E., and Carmines, E. L. (2002). Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food Chem. Toxicol. 40, 93-104.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 93-104
    • Rustemeier, K.1    Stabbert, R.2    Haussmann, H.J.3    Roemer, E.4    Carmines, E.L.5
  • 43
    • 0036073267 scopus 로고    scopus 로고
    • Dermal exposure assessment in occupational medicine
    • Sartorelli, P. (2002). Dermal exposure assessment in occupational medicine. Occup. Med. (Lond.) 52, 151-156.
    • (2002) Occup. Med. (Lond.) , vol.52 , pp. 151-156
    • Sartorelli, P.1
  • 44
    • 0031594861 scopus 로고    scopus 로고
    • Prediction of percutaneous absorption from physicochemical data: A model based on data of in vitro experiments
    • Sartorelli, P., Aprea, C., Cenni, A., Novelli, M. T., Orsi, D., Palmi, S., and Matteucci, G. (1998). Prediction of percutaneous absorption from physicochemical data: A model based on data of in vitro experiments. Ann. Occup. Hyg. 42, 267-276.
    • (1998) Ann. Occup. Hyg. , vol.42 , pp. 267-276
    • Sartorelli, P.1    Aprea, C.2    Cenni, A.3    Novelli, M.T.4    Orsi, D.5    Palmi, S.6    Matteucci, G.7
  • 46
    • 1842431010 scopus 로고    scopus 로고
    • Dermal exposure to chemicals in the workplace: Just how important in skin absorption?
    • Semple, S. (2004). Dermal exposure to chemicals in the workplace: Just how important in skin absorption? Occup. Environ. Med. 61, 376-382.
    • (2004) Occup. Environ. Med. , vol.61 , pp. 376-382
    • Semple, S.1
  • 47
    • 24944432400 scopus 로고    scopus 로고
    • Assessing occupational and environmental exposure
    • Semple, S. (2005). Assessing occupational and environmental exposure. Occup. Med. (Lond.) 55, 419-424.
    • (2005) Occup. Med. (Lond.) , vol.55 , pp. 419-424
    • Semple, S.1
  • 48
    • 4444340013 scopus 로고    scopus 로고
    • Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)
    • Serdar, B., Egeghy, P. P., Gibson, R., and Rappaport, S. M. (2004). Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8). Am. J. Ind. Med. 46, 234-244.
    • (2004) Am. J. Ind. Med. , vol.46 , pp. 234-244
    • Serdar, B.1    Egeghy, P.P.2    Gibson, R.3    Rappaport, S.M.4
  • 50
    • 0034764187 scopus 로고    scopus 로고
    • Progress in methodologies for evaluating bioequivalence of topical formulations
    • Shah, V. P. (2001). Progress in methodologies for evaluating bioequivalence of topical formulations. Am. J. Clin. Dermatol. 2, 275-280.
    • (2001) Am. J. Clin. Dermatol. , vol.2 , pp. 275-280
    • Shah, V.P.1
  • 51
    • 0025940983 scopus 로고
    • Pharmacokinetics of the dermal route of exposure to volatile organic chemicals in water: A computer simulation model
    • Shatkin, J. A., and Brown, H. S. (1991). Pharmacokinetics of the dermal route of exposure to volatile organic chemicals in water: A computer simulation model. Environ. Res. 56, 90-108.
    • (1991) Environ. Res. , vol.56 , pp. 90-108
    • Shatkin, J.A.1    Brown, H.S.2
  • 52
    • 0030956772 scopus 로고    scopus 로고
    • Structural identifiability of PBPK models: Practical consequences for modeling strategies and study designs
    • Slob,W., Janssen, P. H., and van den Hof, J. M. (1997). Structural identifiability of PBPK models: Practical consequences for modeling strategies and study designs. Crit. Rev. Toxicol. 27, 261-272.
    • (1997) Crit. Rev. Toxicol. , vol.27 , pp. 261-272
    • Slob, W.1    Janssen, P.H.2    van den Hof, J.M.3
  • 53
    • 0037599489 scopus 로고    scopus 로고
    • Subcommittee on Jet-Propulsion Fuel 8. The National Academies Press, Washington, DC
    • Subcommittee on Jet-Propulsion Fuel 8 (2003). Toxicologic Assessment of Jet-Propulsion Fuel 8. The National Academies Press, Washington, DC.
    • (2003) Toxicologic Assessment of Jet-Propulsion Fuel 8
  • 55
    • 0003473732 scopus 로고    scopus 로고
    • U.S. EPA. U.S. Environmental Protection Agency, Washington, DC
    • U.S. EPA (1998). Toxicological Review of Naphthalene. U.S. Environmental Protection Agency, Washington, DC.
    • (1998) Toxicological Review of Naphthalene
  • 56
    • 0242717588 scopus 로고    scopus 로고
    • Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry
    • Waidyanatha, S., Zheng, Y., and Rappaport, S. M. (2003). Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry. Chem. Biol. Interact. 145, 165-174.
    • (2003) Chem. Biol. Interact. , vol.145 , pp. 165-174
    • Waidyanatha, S.1    Zheng, Y.2    Rappaport, S.M.3
  • 57
    • 0034763336 scopus 로고    scopus 로고
    • A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice
    • Willems, B. A. T., Melnick, R. L., Kohn, M. C., and Portier, C. J. (2001). A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice. Toxicol. Appl. Pharmacol. 176, 81-91.
    • (2001) Toxicol. Appl. Pharmacol. , vol.176 , pp. 81-91
    • Willems, B.A.T.1    Melnick, R.L.2    Kohn, M.C.3    Portier, C.J.4
  • 58
    • 0029012486 scopus 로고
    • A biophysically based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically applied agents. I. Theory
    • Williams, P. L., and Riviere, J. E. (1995). A biophysically based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically applied agents. I. Theory. J. Pharm. Sci. 84, 599-608.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 599-608
    • Williams, P.L.1    Riviere, J.E.2
  • 59
    • 33747892958 scopus 로고    scopus 로고
    • acslXtreme Optimum user's guide version 1.4
    • AEgis Technologies Group Inc. Huntsville, AL
    • AEgis Technologies Group Inc. (2004). acslXtreme Optimum user's guide version 1.4. Huntsville, AL.
    • (2004)


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