Factor V Leiden mutation, deficiency of antithrombin III and elevation of factor VIII in a child with ischemic stroke: A case report

Brain and Development

Volumn 28, Issue 9, 2006, Pages 604-606

  Duran, Ridvan ^a   Biner, Betül ^a   Demir, Muzaffer ^a   Çeltik, Coşkun ^a   Karasalihoǧlu, Serap ^a   Acunaş, Betül ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Antithrombin deficiency; Child; Factor V Leiden; Factor VIII; Ischemic stroke

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8;

ANTERIOR CEREBRAL ARTERY; ANTITHROMBIN III DEFICIENCY; ARTICLE; BRAIN ISCHEMIA; BRAIN REGION; CASE REPORT; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; HEMIPLEGIA; HETEROZYGOSITY; HOSPITAL ADMISSION; HUMAN; MALE; PRESCHOOL CHILD; RISK FACTOR; THROMBOPHILIA;

ANTITHROMBIN III DEFICIENCY; CEREBROVASCULAR ACCIDENT; CHILD, PRESCHOOL; FACTOR V; FACTOR VIII; HUMANS; MALE; MUTATION; STROKE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33747875765     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.braindev.2006.03.008     Document Type: Article

References (10)

1. Bick R.L., and Kaplan H. Syndromes of thrombosis and hypercoagulability. Congenital and acquired causes of thrombosis. Med Clin North Am 82 (1998) 409-458
2. O'Donnell J., Mumford A.D., Manning R.A., and Laffan M. Elevation of FVIII:C in venous thromboembolism is persistent and independent of acute phase response. Thromb Haemost 83 (2000) 10-13
3. Kenet G., Sadetzki S., Murad H., Martinowitz U., Rosenberg N., Gitel S., et al. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 31 (2000) 1283-1288
4. Akar N., Akar E., Deda G., Sipahi T., and Orsal A. Factor V1691 G-A, prothrombin 20210 G-A and methylentetrahydrofolate reductase 677 C-T variants in Turkish children with cerebral infarct. J Child Neurol 14 (1999) 749-751
5. Dahlback B., Carlsson M., and Svensson P.J. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 90 (1993) 1004-1008
6. Duran R., Biner B., Demir M., Celtik C., and Karasalihoglu S. Factor V Leiden mutation and other thrombophilia markers in childhood ischemic stroke. Clin Appl Thromb Hemost 11 (2005) 83-88
7. Kurekci A.E., Gokce H., and Akar N. Factor VIII levels in children with thrombosis. Pediatr Int 45 (2003) 159-162
8. de Veber G., Monagle P., Chan A., MacGregor D., Curtis R., Lee S., et al. Prothrombotic disorders in infants and children with cerebral thromboembolism. Arch Neurol 55 (1998) 1539-1543
9. Lewandowski K., Rozek M., Turowiecka Z., Markiewicz W.T., and Zawilska K. Combined hemostatic defects in family members of symptomatic carriers of Leiden mutations of factor V. Pol Arch Med Wewn 99 (1998) 211-217
10. Deda G., Icagasioglu D., Caksen H., and Akar N. Combined genetic defects in a child with ischemic stroke: case report. J Child Neurol 17 (2002) 533-534