Agglomeration tendency in dry pharmaceutical granular systems

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 64, Issue 2, 2006, Pages 193-199

  Lachiver, Emilie DesRosiers ^a,c   Abatzoglou, Nicolas ^a   Cartilier, Louis ^b   Simard, Jean Sébastien ^c  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Agglomeration; Flow; Granular systems; Lubricant; Mixing; Powder

Indexed keywords

CALCIUM CARBONATE; MAGNESIUM STEARATE; XYLITAB; XYLITOL;

ARTICLE; PARTICLE SIZE; POWDER; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; THEORETICAL STUDY;

ANALYSIS OF VARIANCE; CALCIUM CARBONATE; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; MODELS, STATISTICAL; PARTICLE SIZE; PRECIPITATION; STEARIC ACIDS; XYLITOL;

EID: 33747871930     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.04.005     Document Type: Article

References (23)

1. Abatzoglou N., and Simard J.-S. Prediction of segregation tendency occurrence in dry particulate pharmaceutical mixtures: development of a mathematical tool adapted for granular systems application. Pharm. Dev. Technol. 10 1 (2005) 59-70
2. Cartilier L.H., and Moës A.J. Effect of drug agglomerates upon the kinetics of mixing of low dosage cohesive powder mixtures. Drug Dev. Ind. Pharm. 15 12 (1989) 1911-1931
3. Harnby N., Edwards M.F., and Nienow A.W. Mixing in the Process Industries (1985), Butterworths, London p. 374
4. Lieberman A., Lachman L., and Schwartz J.B. Pharmaceutical Dosage Forms: Tablets (1990), Marcel Dekker, New York vol. 2, pp. 1-71
5. Gotoh K., Masuda H., and Higashitani K. Powder Technology Handbook. second ed. (1997), Marcel Dekker, New York p. 944
6. Podczeck F., Newton J.M., and James M.B. Influence of relative humidity of storage air on the adhesion and autoadhesion of micronized particles to particulate and compacted powder surfaces. J. Colloid Interf. Sci. 187 (1997) 484-491
7. Visser J. Particle adhesion and removal: a review. Particul. Sci. Technol. 13 (1995) 169-196
8. Villiers M.M. Influence of agglomeration of cohesive particles on the dissolution behaviour of furosemide powder. Int. J. Pharm. 136 (1996) 175-179
9. Piret J.J., and Poidras P.J. How to manage electrostatic problems in bulk solids processing. Powder Bulk Eng. 3 8 (1989) 51-59
10. Staniforth J.N., and Rees J.E. Electrostatic charge interactions in ordered powder mixes. J. Pharm. Pharmacol. 34 (1982) 69-76
11. Orr N.A., and Sallam E.A. Content uniformity of potent drugs in tablets. J. Pharm. Pharmacol. 30 12 (1978) 741-747
12. Kaye B.H. Powder Mixing (1997), Chapman & Hall, London p. 263
13. Muzzio F., and Alexander A. Scale up of powder-blending operations. Pharm. Technol. 29 Suppl. (2005) 34-42
14. Fuller W.O., and Abbé P.O. Mixing up a batch: batch mixer types and selection tips. Powder Bulk Eng. 12 1 (1998) 48-66
15. Ottino J.M., and Khakhar D.V. Fundamental research in heaping, mixing, and segregation of granular materials: challenges and perspectives. Powder Technol. 121 (2001) 117-122
16. Jimenez B., Chulia D., Jeannin C., Lemaître B., Ozil P., and Verain A. Comportement mécanique des poudres. Étude paramétrique du fonctionnement d'un mélangeur-réservoir, validation des conditions d'emploi d'un mélangeur-réservoir de poudres. Pharm. Acta Helv. 61 10-11 (1986) 282-291
17. Deiva Venkatesh R., Grmela M., and Chaouki J. Simulations of vibrated fine powders. Powder Technol. 100 (1998) 211-222
18. Montgomery D.C. Design and Analysis of Experiments. fifth ed. (2001), Wiley, New York p. 684
19. Rowe R.C., Sheskey P.J., and Weller P.J. Handbook of Pharmaceutical Excipients. fourth ed. (2003), American Pharmaceutical Association and Pharmaceutical Press, London p. 776
20. Cartilier L.H., and Moës A.J. Influence du type de lactose sur l'homogénéité de mélanges de poudres à principe actif cohésif et faiblement dosé. S.T.P. Pharma 5 3 (1989) 152-159
21. Villiers M.M. Description of the kinetics of the deagglomeration of drug particle agglomerates during powder mixing. Int. J. Pharm. 151 (1997) 1-6
22. E.B. Mpenza, Électricité statique en technologie des poudres pharmaceutiques: sa mesure, son élimination et son influence, Ph.D. thesis, Université Catholique de Louvain, 1981.
23. E.D. Lachiver, N. Abatzoglou, L. Cartilier, J.-S. Simard, Insights into the role of electrostatic forces on the behavior of dry pharmaceutical particulate systems, Pharm. Res. Springer US, 13(5) (2006) 997-1007.