Non-involvement of the human monocarboxylic acid transporter 1 (MCT1) in the transport of phenolic acid

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 8, 2006, Pages 1928-1933

  Watanabe, Hirohito ^a   Yashiro, Takuya ^a   Tohjo, Yuichi ^a   Konishi, Yutaka ^b  

^a MEIJI UNIVERSITY   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

Author keywords

Fluorescein; MCT1; Monocarboxylic acid transporter (MCT); Phenolic acid

Indexed keywords

ABSORPTION; CELLS; METABOLITES; MICROBIOLOGY; PHENOLS; SODIUM COMPOUNDS; TISSUE;

FLUORESCEIN; MONOCARBOXYLIC ACID TRANSPORTER (MCT); PHENOLIC ACID; SALICYLIC ACID;

CARBOXYLIC ACIDS;

4-COUMARIC ACID; BUTYRIC ACID DERIVATIVE; COTRANSPORTER; COUMARIC ACID; FLUORESCEIN DERIVATIVE; HYDROXYBENZOIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; PARA COUMARIC ACID; PHENOLIC ACID; SALICYLIC ACID;

ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; CHEMISTRY; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; OOCYTE; PERMEABILITY;

BUTYRATES; CACO-2 CELLS; COUMARIC ACIDS; FLUORESCEINS; HUMANS; HYDROXYBENZOIC ACIDS; MONOCARBOXYLIC ACID TRANSPORTERS; OOCYTES; PERMEABILITY; SALICYLIC ACID; SYMPORTERS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 33747845590     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60093     Document Type: Article

References (23)

1. WHO/FAO, Diet, nutrition and the prevention of chronic diseases. Geneva: World Health Organization, 2003.
2. Scalbert, A., Johnson, I. T., and Saltmarsh, M., Polyphenols: antioxidants and beyond. Am. J. Clin. Nutr., 81, 215S-217S (2005).
3. Clifford, M. N., Chlorogenic acids and other cinnamates: nature, occurrence, and dietary burden. J. Sci. Food Agric., 79, 362-372 (1999).
4. Konishi, Y., and Shimizu, M., Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers. Biosci. Biotechnol. Biochem., 67, 856-862 (2003).
5. Konishi, Y., Kobayashi, S., and Shimizu, M., Transepithelial transport of p-coumaric acid and gallic acid by monocarboxylic acid transporter in Caco-2 cell monolayers. Biosci. Biotechnol. Biochem., 67, 2317-2324 (2003).
6. Konishi, Y., and Kobayashi, S., Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal Caco-2 cell monolayers. J. Agric. Food Chem., 52, 2518-2526 (2004).
7. Konishi, Y., and Kobayashi, S., Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers. Biosci. Biotechnol. Biochem., 69, 583-591 (2005).
8. Konishi, Y., Transepithelial transport of artepillin C in intestinal Caco-2 cell monolayers. Biochim. Biophys. Acta, 1713, 138-144 (2005).
9. Konishi, Y., Hitomi, Y., and Yoshioka, E., Intestinal absorption of p-coumaric and gallic acids in rats after oral administration. J. Agric. Food Chem., 52, 2527-2532 (2004).
10. Konishi, Y., Hitomi, Y., Yoshida, M., and Yoshioka, E., Intestinal absorption of caffeic and rosmarinic acids in rats after oral administration. J. Agric. Food Chem., 53, 4740-4746 (2005).
11. Konishi, Y., Hitomi, Y., Yoshida, M., and Yoshioka, E., Absorption and bioavailability of artepillin C in rats after oral administration. J. Agric. Food Chem., 53, 9928-9933 (2005).
12. Konishi, Y., and Kobayashi, S., Microbial metabolites of ingested caffeic acid are absorbed by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. J. Agric. Food Chem., 52, 6418-6424 (2004).
13. Konishi, Y., Transepithelial transport of microbial metabolites of quercetin in intestinal Caco-2 cell monolayers. J. Agric. Food Chem., 53, 601-607 (2005).
14. Halestrap, A. P., and Meredith, D., The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch., 447, 619-628 (2004).
15. Lin, R. Y., Vera, J. C., Chaganti, R. S. K., and Golde, D. W., Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J. Biol. Chem., 273, 28959-28969 (1998).
16. Broer, S., Schneider, H. P., Broer, A., Rahman, B., Hamprecht, B., and Deitmer, J. W., Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem. J., 333, 167-174 (1998).
17. Konishi, Y., Hagiwara, K., and Shimizu, M., Transepithelial transport of fluorescein in Caco-2 cell monolayers and its use in in vitro evaluation of phenolic acids availability. Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002).
18. Tamai, I., Sai, Y., Ono, A., Kido, Y., Yabuuchi, H., Takanaga, H., Satoh, E., Ogihara, T., Amano, O., Izeki, S., and Tsuji, A., Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J. Pharm. Pharmacol., 51, 1113-1121 (1999).
19. Konishi, Y., Kubo, K., and Shimizu, M., Structural effects of phenolic acids on the transepithelial transport of fluorescein in Caco-2 cell monolayers. Biosci. Biotechnol. Biochem., 67, 2317-2324 (2003).
20. Itagaki, S., Otsuka, Y., Kubo, S., Okumura, H., Saito, Y., Kobayashi, M., Hirano, T., and Iseki, K., Intestinal uptake of nateglinide by an intestinal fluorescein transporter. Biochim. Biophys. Acta, 1668, 190-194 (2005).
21. + cotransport system. J. Agric. Food Chem., 53, 2499-2502 (2005).
22. Cuff, M. A., Lambert, D. W., and Shirazi-Beechey, S. P., Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J. Physiol., 539, 361-371 (2002).
23. Hadjiagapiou, C., Schmidt, L., Dudeja, P. K., Layden, T. J., and Ramaswamy, K., Mechanism of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. Am. J. Physiol. Gastrointest. Liver Physiol., 279, G775-780 (2000).