18F-CPFPX PET: On the generation of parametric images and the effect of scan duration

Journal of Nuclear Medicine

Volumn 47, Issue 2, 2006, Pages 200-207

  Meyer, Philipp T ^a   Elmenhorst, David ^a   Matusch, Andreas ^a   Winz, Oliver ^a   Zilles, Karl ^a   Bauer, Andreas ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

18F CPFPX; A1 adenosine receptor; Parametric imaging; PET

Indexed keywords

FLUORINE 8 CYCLOPENTYL 3 (3 FLUOROPROPYL) 1 PROPYLXANTHINE F 18; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; 8 CYCLOPENTA 3 (3 FLUOROPROPYL) 1 PROPYLXANTHINE; 8-CYCLOPENTA-3-(3-FLUOROPROPYL)-1-PROPYLXANTHINE; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ACCURACY; ADULT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; MALE; NORMAL DISTRIBUTION; NORMAL HUMAN; PARAMETRIC TEST; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; ALGORITHM; BRAIN; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; IMAGE ENHANCEMENT; METHODOLOGY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL IMAGING; TIME;

ADULT; ALGORITHMS; BRAIN; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS; XANTHINES;

EID: 33747760806     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Holschbach MH, Olsson RA, Bier D, et al. Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. J Med Chem. 2002;45:5150-5156.
2. 18F]CPFPX and positron emission tomography. Neuroimage. 2003;19:1760-1769.
3. Dunwiddie TV, Masino SA. The role and regulation of adenosine in the central nervous system. Annu Rev Neurosci. 2001;24:31-55.
4. Cunha RA. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem Int. 2001;38:107-125.
5. Mintun MA, Raichle ME, Kilbourn MR, et al. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol. 1984;15:217-227.
6. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990;10:740-747.
7. 18F]CPFPX and PET. J Cereb Blood Flow Metab. 2004;24:323-333.
8. 18F]CPFPX and PET: an equilibrium approach. Neuroimage. 2005;24:1192-1204.
9. Slifstein M, Laruelle M. Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med. 2000;41:2083-2088.
10. Logan J, Fowler JS, Volkow ND, et al. A strategy for removing the bias in the graphical analysis method. J Cereb Blood Flow Metab. 2001;21:307-320.
11. Varga J, Szabo Z. Modified regression model for the Logan plot. J Cereb Blood Flow Metab. 2002;22:240-244.
12. Ichise M, Toyama H, Innis RB, et al. Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab. 2002;22:1271-1281.
13. Parsey RV, Ogden RT, Mann JJ. Determination of volume of distribution using likelihood estimation in graphical analysis: elimination of estimation bias. J Cereb Blood Flow Metab. 2003;23:1471-1478.
14. Pietrzyk U, Herholz K, Fink G, et al. An interactive technique for three-dimensional image registration: validation for PET, SPECT, MRI and CT brain studies. J Nucl Med. 1994;35:2011-2018.
15. Burger C, Buck A. Requirements and implementation of a flexible kinetic modeling tool. J Nucl Med. 1997;38:1818-1823.
16. Feng D, Huang SC, Wang Z, et al. An unbiased parametric imaging algorithm for non-uniformly sampled biomedical system parameter estimation. IEEE Trans Med Imaging. 1996;15:512-518.
17. Millet P, Delforge J, Mauguiere F, et al. Parameter and index images of benzodiazepine receptor concentration in the brain. J Nucl Med. 1995;36:1462-1471.
18. 11C]clorgyline. J Cereb Blood Flow Metab. 2002;22:1367-1376.
19. Millet P, Ibanez V, Delforge J, et al. Wavelet analysis of dynamic PET data: application to the parametric imaging of benzodiazepine receptor concentration. Neuroimage. 2000;11:458-472.
20. 11C]FLB 457. Neuroimage. 2002;17:47-60.
21. Zhou Y, Endres CJ, Brasic JR, et al. Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model. Neuroimage. 2003;18:975-989.
22. Friston KJ, Frith CD, Liddle PF, et al. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab. 1991;11:690-699.