Clinical and laboratory importance of prolactin macromolecular isoforms;Impatto clinico e laboratoristico delle isoforme macromolecolari della prolattina

Rivista Italiana della Medicina di Laboratorio

Volumn 1, Issue 2, 2005, Pages 123-129

  Marcolla, A ^a   Dilberis, C ^b   Dal Bosco, F ^c   Amadori, Pierluigi ^c,d  

^a Ospedale di Cles   (Italy)

^b SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^c APSS   (Italy)

^d Azienda Provinciale   (Italy)

Author keywords

BigBigprolactin; Immunoassay; Immunocomplex; Macroprolactin; PEG

Indexed keywords

ISOPROTEIN; MACROPROLACTIN; PROLACTIN; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; GEL CHROMATOGRAPHY; HUMAN; HYPERPROLACTINEMIA; IMMUNOASSAY; MACROMOLECULE; MOLECULAR WEIGHT; PROLACTIN BLOOD LEVEL; PROTEIN ANALYSIS; REVIEW; SENSITIVITY AND SPECIFICITY;

EID: 33747754458     PISSN: 1825859X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (51)

1. Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000; 80:1523-631.
2. Smith CR, Norman MR. Prolactin and growth hormone: molecular heterogeneity and measurement in serum. Ann Clin Biochem 1990; 27:542-50.
3. Smith TP, Suliman AM, Fahie-Wilson MN, McKenna TJ. Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays. J Clin Endocrinol Metab 2002; 87:5410-5.
4. Schlechte JA. Editorial: the macroprolactin problem. J Clin Endocrinol Metab 2002; 87:5408-9.
5. Sinha YN. Structural variants of prolactin: occurrence and physiological significance. Endocr Rev 1995; 16:354-69.
6. Kline JB, Clevenger CV. Identification and characterization of the prolactin-binding protein in human serum and milk. J Biol Chem 2001; 276:24760-6.
7. Sweefoong NG, Richards RJ, Ward GJ, Kunze HF, Irving MJ, Cameron DP. Big big prolactin-what is it? 29th annual meeting of the Endocrine Society of Australia 1986; Abstract n 136.
8. Carlson HE, Markoff E, Lee DW. On the nature of serum prolactin in two patients with macroprolactinemia. Fertil Steril 1992; 58:78-87.
9. Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H. A normal ovulatory woman with hyperprolactinemia: presence of anti-prolactin autoantibody and the regulation of prolactin secretion. Acta Endocrinol (Copenh) 1992; 126:497-500.
10. Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H. Correlation of the antibody titers with serum prolactin levels and their clinical course in patients with anti-prolactin autoantibody. Eur J Endocrinol 1994; 130:438-45.
11. Hattori N. The frequency of macroprolactinemia in pregnant women and the heterogeneity of its etiologies. J Clin Endocrinol Metab 1996; 81:586-90.
12. Cavaco B, Leite V, Santos MA, Arranhado E, Sobrinho LG. Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma. J Clin Endocrinol Metab 1995; 80:2342-6.
13. Schiettecatte J, De Schepper J, Velkeniers B, Smitz J, Van Steirteghem A. Rapid detection of macroprolactin in the form of prolactin-immunoglobulin G complexes by immunoprecipitation with anti-human IgG-agarose. Clin Chem Lab Med 2001; 39:1244-8.
14. Hattori N. Macroprolactinemia: a new cause of hyperprolactinemia. J Pharmacol Sci 2003; 92:171-7.
15. Amadori P, Dilberis C, Marcolla A, Pinamonti M, Menapace P, Valentini A. Identification of IgG-immunocomplex macroprolactin with an immunometric "sandwich" system: techincal and clinical considerations. J Endocrinol Invest 2004; 27:1022-8.
16. Leanos-Miranda A, Pascoe-Lira D, Chavez-Rueda KA, Blanco-Favela F. Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia. Lupus 2001; 10:340-5.
17. Strachan MW, Teoh WL, Don-Wauchope AC, Seth J, Stoddart M, Beckett GJ. Clinical and radiological features of patients with macroprolactinaemia. Clin Endocrinol (Oxf) 2003; 59:339-46.
18. Leslie H, Courtney CH, Bell PM, Hadden DR, McCance DR, Ellis PK, et al. Laboratory and clinical experience in 55 patients with macroprolactinemia identified by a simple polyethylene glycol precipitation method. J Clin Endocrinol Metab 2001; 86:2743-6.
19. Fideleff HL, Ruibal G, Boquete H, Pujol A, Sequera A, Sobrado P. Macroprolactinemia in childhood and adolescence: a cause of asymptomatic hyperprolactinemia. Horm Res 2000; 53:16-9.
20. Leanos-Miranda A, Contreras-Hernandez I. Related Articles, Antiprolactin autoantibodies are associated with hyperprolactinemic status in men infected with human immunodeficiency virus. Endocrine 2002; 19:139-46.
21. Olukoga AO, Kane JW. Macroprolactinaemia: validation and application of the polyethylene glycol precipitation test and clinical characterization of the condition. Clin Endocrinol (Oxf) 1999; 5:119-26.
22. Vallette-Kasic S, Morange-Ramos I, Selim A, Gunz G, Morange S, Enjalabert M, et al. Macroprolactinemia revisited: a study on 106 patients. J Clin Endocrinol Metab 2002; 87:581-8.
23. Cavaco B, Prazeres S, Santos MA, Sobrinho LG, Leite V. Hyperprolactinemia due to big big prolactin is differently detected by commercially available immunoassays. J Endocrinol Invest 1999; 22:203-8.
24. Leite V, Cosby H, Sobrinho LG, Fresnoza MA, Santos MA, Friesen HG. Characterization of big, big prolactin in patients with hyperprolactinaemia. Clin Endocrinol (Oxf) 1992; 37:365-72
25. Leanos-Miranda A, Pascoe-Lira D, Chavez-Rueda KA, Blanco-Favela F. Persistence of macroprolactinemia due to antiprolactin autoantibody before, during, and after pregnancy in a woman with systemic lupus erythematosus. J Clin Endocrinol Metab 2001; 86:2619-24.
26. Leanos-Miranda A, Chavez-Rueda KA, Blanco-Favela F. Biologic activity and plasma clearance of prolactin-IgG complex in patients with systemic lupus erythematosus. Arthritis Rheum 2001; 44:866-75
27. Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H. Effects of anti-prolactin autoantibodies on serum prolactin measurements. Eur J Endocrinol 1994; 130:434-7.
28. Gibson G, Schmit P, Thix J, Hoffman JP, Humbel RL. Prolactin results for samples containing macroprolactin are method and sample dependent. Clin Chem 2001; 47:331-3.
29. Schneider W, Marcovitz S, Al-Shammari S, Yago S, Chevalier S. Reactivity of macroprolactin in common automated immunoassays. Clin Biochem. 2001; 34:469-73.
30. Hekim C, Alfthan H, Leinonen JT, Stenman UH. Effect of incubation time on recognition of various forms of prolactin in serum by the DELFIA assay. Clin Chem 2002; 48:2253-6.
31. Suh HK, Frantz AG. Size heterogeneity of human prolactin in plasma and pituitary extracts. J Clin Endocrinol Metab 1974; 39:928-35.
32. Fahie-Wilson MN, Soule SG. Macroprolactinaemia: contribution to hyperprolactinaemia in a district general hospital and evaluation of a screening test based on precipitation with polyethylene glycol. Ann Clin Biochem 1997; 34:252-8.
33. Fahie-Wilson M, Brunsden P, Surrey J, Everitt A. Macroprolactin and the Roche Elecsys prolactin assay: characteristics of the reaction and detection by precipitation with polyethylene glycol. Clin Chem 2000; 46:1993-5.
34. Pascoe-Lira D, Duran-Reyes G, Contreras-Hernandez I, Manuel-Apolinar L, Blanco-Favela F, Leanos-Miranda A. Frequency of macroprolactinemia due to autoantibodies against prolactin in pregnant women. J Clin Endocrinol Metab 2001; 86:924-9.
35. Suliman AM, Smith TP, Gibney J, McKenna TJ. Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia. Clin Chem 2003; 49:1504-9.
36. Amadori P, Dilberis C, Marcolla A, Pinamonti M, Menapace P, Dal Bosco F. Macroprolactinemia: predictability on clinical basis and detection by PEG precipitation with two different immunometric methods. J Endocrinol Invest 2003; 26:148-5.
37. Craddock HS, Fahie-Wilson M, Heys AD. Macroprolactin detection by ultrafiltration screening with the Abbott AxSYM assay. Proceedings of Pathology 2000. Association of Clinical Biochemists National Meeting. London: The Association of Clinical Biochemists, p. 148.
38. Prazeres S, Santos MA, Ferreira HG, Sobrinho LG. A practical method for the detection of macroprolactinaemia using ultrafiltration. Clin Endocrinol (Oxf) 2003; 58:686-90.
39. Sapin R, Kertesz G. Macroprolactin detection by precipitation with protein A-sepharose: a rapid screening method compared with polyethylene glycol precipitation. Clin Chem 2003; 49:502-5.
40. Sanchez-Eixeres MR, Mauri M, Alfayate R, Graells ML, Miralles C, Lopez A, et al. Prevalence of macroprolactin detected by Elecsys 2010. Horm Res 2001; 56:87-92.
41. Vieira JG, Tachibana TT, Obara LH, Maciel RM. Extensive experience and validation of polyethylene glycol precipitation as a screening method for macroprolactinemia. Clin Chem 1998; 44:1758-9.
42. De Schepper J, Schiettecatte J, Velkeniers B, Blumenfeld Z, Shteinberg M, Devroey G, et al. Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes. Eur J Endocrinol 2003; 149:201-7.
43. Cattaneo FA, Fahie-Wilson MN. Concomitant occurrence of macroprolactin, exercise-induced amenorrhea, and a pituitary lesion: a diagnostic pitfall. Case report. J Neurosurg 2001; 95:334-7.
44. Sapin R, Simon C. False hyperprolactinemia corrected by the use of heterophilic antibody-blocking agent. Clin Chem 2001; 47:2184-5.
45. John R, McDowell IF, Scanlon MF, Ellis AR. Macroprolactin reactivities in prolactin assays: an issue for clinical laboratories and equipment manufacturers. Clin Chem 2000; 46:884-5.
46. Serri O, Chik CL, Ur E, Ezzat S. Diagnosis and management of hyperprolactinemia. CMAJ 2003; 169:575-81.
47. Hauache OM, Rocha AJ, Maia AC, Maciel RM, Vieira J. Clin Endocrinol (Oxf) 2002; 57:327-31.
48. Ohnami S, Eto S, Ohnami S, Soejima T, Nakata H. Characterization of "big big prolactin" in serum and tumor extract in patients with PRL-secreting tumor. Endocrinol Jpn 1987; 34:325-34.
49. Tritos NA, Guay AT, Malarkey WB. Asymptomatic 'big' hyperprolactinemia in two men with pituitary adenoma. Eur J Endocrinol 1998; 138:82-5.
50. Mounier C, Trouillas J, Claustrat B, Duthel R, Estour B. Macroprolactinaemia associated with prolactin adenoma. Hum Reprod 2003; 18:853-7.
51. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor, actions, signal transduction pathways and phenotipes observed in PRL receptor knockout mice. Endocr Rev 1998; 19:225-68.