Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity

European Journal of Endocrinology

Volumn 155, Issue 2, 2006, Pages 261-268

  Franco, Celina ^a   Veldhuis, Johannes D ^b   Iranmanesh, Ali ^c   Brandberg, John ^a   Lönn, Lars ^a   Andersson, Björn ^a   Bengtsson, Bengt Åke ^a   Svensson, Johan ^a   Johannsson, Gudmundur ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b MAYO CLINIC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BIOASSAY; BLOOD SAMPLING; BODY FAT DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DENATURATION; ENTROPY; FAT CONTENT; FEMALE; GROWTH HORMONE RELEASE; HORMONE DETERMINATION; HUMAN; LIVER; MULTIPLE REGRESSION; NEUROENDOCRINE SYSTEM; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; REGRESSION ANALYSIS; THIGH;

ABDOMINAL FAT; ADIPOSE TISSUE; AGED; BIOLOGICAL MARKERS; BODY FAT DISTRIBUTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMAN GROWTH HORMONE; HUMANS; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; POSTMENOPAUSE; REGRESSION ANALYSIS; RISK FACTORS; THIGH;

EID: 33747678664     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02211     Document Type: Article

References (41)

1. Bengtsson BA, Rosén T, Johansson J-O, Johansson G, Oscarsson J and Landin-Wilhelmsen K. Cardiovascular risk factors in adults with growth hormone deficiency. Endocrinology and Metabolism 1995 2 (Suppl B) 29-35.
2. Bjorntorp P. Regional fat distribution-implications for type II diabetes. International Journal of Obesity and Related Metabolic Disorders 1992 16 (Suppl 4) S19-S27.
3. Veldhuis JD and Iranmanesh A. Physiological regulation of the human growth hormone GH-insulin-like growth factor type IIGF-I axis: predominant impact of age, obesity, gonadal function, and sleep. Sleep 1996 19 S221-S224.
4. Veldhuis JD, Liem AY, South S, Weltman A, Weltman J, Clemmons DA, Abbott R, Mulligan T, Johnson ML and Pincus S. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. Journal of Clinical Endocrinology and Metabolism 1995 80 3209-3222.
5. Veldhuis JD and Bowers CY. Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen. Journal of Pediatric Endocrinology and Metabolism 2003 6 (Suppl 3) 587-605.
6. Vahl N, Jorgensen JO, Skjaerbaek C, Veldhuis JD, Orskov H and Christiansen JS. Abdominal adiposity rather than age and sex predicts mass and regularity of GH secretion in healthy adults. American Journal of Physiology 1997 272 E1108-E1116.
7. Brummer RJ, Lonn L, Kvist H, Grangard U, Bengtsson BA and Sjostrom L. Adipose tissue and muscle volume determination by computed tomography in acromegaly, before and 1 year after adenomectomy. European Journal of Clinical Investigation 1993 23 199-205.
8. Lonn L, Johansson G, Sjostrom L, Kvist H, Oden A and Bengtsson BA. Body composition and tissue distributions in growth hormone deficient adults before and after growth hormone treatment. Obesity Research 1996 4 45-54.
9. Brummer RJ. Effects of growth hormone treatment on visceral adipose tissue. Growth Hormone & IGF Research 1998 8 (Suppl B) 19-23.
10. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G and Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001 50 1844-1850.
11. Goodpaster BH, Krishnaswami S, Resnick H, Kelley DE, Haggerty C, Harris TB, Schwartz AV, Kritchevsky S and Newman AB. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 2003 26 372-379.
12. DeFronzo RA, Tobin JD and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Phsysiology 1979 237 E214-E223.
13. American Diabetes Association: clinical practice recommedations. Diabetes Care 1997 20 (Suppl 1) S1-S70.
14. Veldhuis JD, Carlson ML and Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. PNAS 1987 84 7686-7690.
15. Pincus SM, Gevers EF, Robinson IC, van den Berg G, Roelfsema F, Hartman ML and Veldhuis JD. Females secrete growth hormone with more process irregularity than males in both humans and rats. American Journal of Physiology 1996 270 E107-E115.
16. Pijl H, Langendonk JG, Burggraaf J, Frofich M, Cohen AF, Veldhuis JD and Meinders AE. Altered neuroregulation of GH secretion in viscerally obese premenopausal women. Journal of Clinical Endocrinology and Metabolism 2001 86 5509-5515.
17. Chowdhury B, Sjostrom L, Alpsten M, Kostanty J, Kvist H and Lofgren R. A multicompartment body composition technique based on computerized tomography. International Journal of Obesity Related and Metabolic Disorders 1994 18 219-234.
18. Starck G, Lonn L, Cederblad A, Forssell-Aronsson E, Sjostrom L and Alpsten M. A method to obtain the same levels of CT image noise for patients of various sizes, to minimize radiation dose. British Journal of Radiology 2002 75 140-150.
19. Ricci C, Longo R, Gioulis E, Bosco M, Pollesello P, Masutti F, Croce LS, Paoletti S, de Bernard B, Tiribelli C and Dalla Palma L. Noninvasive in vivo quantitative assessment of fat content in human liver. Journal of Hepatology 1997 27 108-113.
20. Piekarski J, Goldberg HI, Royal SA, Axel L and Moss AA. Difference between liver and spleen CT numbers in the normal adult: its usefulness in predicting the presence of diffuse liver disease. Radiology 1980 137 727-729.
21. Goodpaster BH, Kelley DE, Thaete FL, He J and Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. Journal of Applied Physiology 2000 89 104-110.
22. Iranmanesh A, Grisso B and Veldhuis JD. Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay. Journal of Clinical Endocrinology and Metabolism 1994 78 526-535.
23. Franco C, Brandberg J, Loon L, Andersson B, Bengtsson BA and Johannsson G. Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism 2005 90 1466-1474.
24. Ovesen P, Vahl N, Fisker S, Veldhuis JD, Christiansen JS and Jorgensen JO. Increased pulsatile, but not basal, growth hormone secretion rates and plasma insulin-like growth factor I levels during the periovulatory interval in normal women. Journal of Clinical Endocrinology and Metabolism 1998 83 1662-1667.
25. Svensson J, Veldhuis JD, Iranmanesh A, Bengtsson BA and Johannsson G. Increased orderliness of growth hormone GH secretion in GH-deficient adults with low serum insulin-like growth factor I. Journal of Clinical Endocrinology and Metabolism 2002 87 2863-2869.
26. Miller KK, Biller BM, Lipman JG, Bradwin G, Rifai N and Klibanski A. Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk. Journal of Clinical Endocrinology and Metabolism 2005 90 768-774.
27. Veldhuis JD, Iranmanesh A, Samojlik E and Urban RJ. Differential sex steroid negative feedback regulation of pulsatile follicle-stimulating hormone secretion in healthy older men: deconvolution analysis and steady-state sex-steroid hormone infusions in frequently sampled healthy older individuals. Journal of Clinical Endocrinology and Metabolism 1997 82 1248-1254.
28. Casanueva FF, Villanueva L, Dieguez C, Diaz Y, Cabranes JA, Szoke B, Scanlon MF, Schally AV and Fernandez-Cruz A. Free fatty acids block growth hormone GH releasing hormone-stimulated GH secretion in man directly at the pituitary. Journal of Clinical Endocrinology and Metabolism 1987 65 634-642.
29. Buijs MM, Burggraaf J, Wijbrandts C, de Kam ML, Frolich M, Cohen AF, Romijn JA, Sauerwein HP, Meinders AE and Pijl H. Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism. American Journal of Clinical Nutrition 2003 77 544-550.
30. Nam SY, Lee EJ, Kim KR, Cha BS, Song YD, Lim SK, Lee HC and Hub KB. Effect of obesity on total and free insulin-like growth factor IGF-1, and their relationship to IGF-binding protein BP-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. International Journal of Obesity Related and Metabolic Disorders 1997 21 355-359.
31. Jansson JO, Albertsson-Wikland K, Eden S, Thorngren KG and Isaksson O. Effect of frequency of growth hormone administration on longitudinal bone growth and body weight in hypophysectomized rats. Acta Physiologica Scandinavica 1982 114 261-265.
32. Clark RG, Jansson JO, Isaksson O and Robinson IC. Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats. Journal of Endocrinology 1985 104 53-61.
33. Isgaard J, Nilsson A, Lindahl A, Jansson JO and Isaksson OG. Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats. American Journal of Physiology 1986 250 E367-E372.
34. Clark RG, Mortensen DL, Carlsson LM, Carlsson B, Carmignac D and Robinson IC. The obese growth hormone GH-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-1. Endocrinology 1996 137 1904-1912.
35. Lumpkin MD, Mulroney SE and Haramati A. Inhibition of pulsatile growth hormone GH secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist. Endocrinology 1989 124 1154-1159.
36. Hartman ML, Clayton PE, Johnson ML, Celniker A, Perlman AJ, Alberti KG and Thorner MO. A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans. Journal of Clinical Investigation 1993 91 2453-2462.
37. Goodpaster BH, Thaete FL and Kelley DE. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. American Journal of Clinical Nutrition 2000 71 885-892.
38. Van Dam EW, Roelfsema F, Helmerhorst FH, Frolich M, Meinders AE, Veldhuis JD and Pijl H. Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2002 87 4225-4230.
39. Gallagher D, Kuznia F, Heshka S, Albu J, Heymsfield SB, Goodpaster B, Visser M and Harris TB. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. American Journal of Clinical Nutrition 2005 81 903-910.
40. Furler SM, Poynten AM, Kriketos AD, Lowy AJ, Ellis BA, Maclean EL, Courtenay BG, Kraegen EW, Campbell LV and Chisholm DJ. Independent influences of central fat and skeletal muscle lipids on insulin sensitivity. Obesity Research 2001 9 535-543.
41. Colberg SR, Simoneau JA, Thaete FL and Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. European Journal of Clinical Investigation 1995 95 1846-1853.