Differential sex steroid negative feedback regulation of pulsatile follicle-stimulating hormone secretion in healthy older men: Deconvolution analysis and steady-state sex-steroid hormone infusions in frequently sampled healthy older individuals

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 4, 1997, Pages 1248-1254

  Veldhuis, Johannes D ^a   Iranmanesh, Ali ^b   Samojlik, Eugeniusz ^c   Urban, Randall J ^d  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b Veterans Affairs Medical Cente   (United States)

^c Department of Medicine   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; SEX HORMONE;

AGED; AGING; ARTICLE; CONTROLLED STUDY; FOLLITROPIN RELEASE; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; NEGATIVE FEEDBACK; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

AGED; AGING; DIHYDROTESTOSTERONE; ESTRADIOL; FEEDBACK; FOLLICLE STIMULATING HORMONE; GONADAL STEROID HORMONES; HALF-LIFE; HOMEOSTASIS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PULSATILE FLOW; REFERENCE VALUES; SPECIMEN HANDLING; TIME FACTORS;

EID: 0030904368     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.4.1248     Document Type: Article

References (76)

1. Urban RJ, Dahl KD, Lippert MC, Veldhuis JD. 1992 Endogenous androgen and estrogen modulate immunoradiometric and bioactive FSH secretion and clearance in young and elderly men. J Androl. 13:579-586.
2. Zambrano E, Olivares A, Mendez JP, Guerrero L, Veldhuis JD, Ulloa-Aguirre A. 1995 Dynamics of basal and GnRH-releasable serum FSH charge isoform distribution throughout the menstrual cycle. J Clin Endocrinol Metab. 80:1647-1656.
3. Veldhuis JD. 1991 The hypothalamic pituitary-testicular axis. In: Yen SSC, Jaffe RB, eds. Reproductive endocrinology. Philadelphia: Saunders; 409-459.
4. Haisenleder DJ, Dalkin AC, Ortolano GA, Marshall JC, Shupnik MA. 1991 A pulsatile GnRH stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology. 128:509-517.
5. Abeyawardene SA, Plant TM. 1989 Bilateral orchidectomy and concomitant testosterone replacement in the juvenile male rhesus monkey (Macaca malutta) receiving an invariant intravenous gonadotropin-releasing hormone (GnRH) infusion results, as in the hypothalamus lesioned GnRH driven adult male, in a selective hypersecretion of follicle stimulating hormone. Endocrinology. 125:257-259.
6. Drouin J, Labrie F. 1976 Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture. Endocrinology. 98:1528-1534.
7. Winters SJ, Sherins RJ, Troen P. 1984 The gonadotropin-suppression activity of androgen is increased in elderly men. Metabolism. 33:1052-1059.
8. Veldhuis JD, King JC, Urban RJ, et al. 1987 Operating characteristics of the male hypothalamo-pituitary-gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. J Clin Endocrinol Metab. 65:929-941.
9. Veldhuis JD, Iranmanesh A, Clarke I, Kaiser DL, Johnson ML. 1989 Random and non-random coincidence between luteinizing hormone peaks and follicle-stimulating hormone, alpha subunit, prolactin, and gonadotropin-releasing hormone pulsations. J Neuroendocrinol. 1:185-194.
10. Mauras N, Rogol AD, Veldhuis JD. 1989 Specific, time-dependent actions of low-dose estradiol administration on the episodic release of GH, FSH and LH in prepubertal girls with Turner's syndrome. J Clin Endocrinol Metab. 69:1053-1058.
11. Veldhuis JD, Johnson ML, Seneta E. 1991 Analysis of the co-pulsatility of anterior pituitary hormones. J Clin Endocrinol Metab. 73:569-576.
12. Urban RJ, Johnson ML, Veldhuis JD. 1991 In vivo biological validation and biophysical modeling of the sensitivity and positive accuracy of endocrine peak detection. II. The FSH pulse signal. Endocrinology. 128:2008-2014.
13. Urban RJ, Dahl KD, Padmanabhan V, Beitins IZ, Veldhuis JD. 1991 Specific regulatory actions of dihydrotestosterone and estradiol on the dynamics of FSH secretion and clearance in man. J Androl. 12:27-35.
14. Booth RAJ, Weltman JY, Yankov VI, et al. 1996 Mode of pulsatile FSH secretion in gonadal-hormone sufficient and deficient women. J Clin Endocrinol Metab. 81:3208-3214.
15. McLeod BJ, Craigon J. 1985 Time series analysis of plasma LH and FSH concentrations as a method of assessing episodic secretion. J Reprod Fertil. 74:575.
16. Dunger DB, Matthews DR, Edge JA, Jones J, Preece MA. 1991 Evidence for temporal coupling of growth hormone, prolactin, LH and FSH pulsatility overnight during normal puberty. J Endocrinol. 130:141-149.
17. Dunkel L, Alfthan H, Stenman UH, Tapanainen P, Perheentupa J. 1990 Pulsatile secretion of LH and FSH in prepubertal and early pubertal boys revealed by ultrasensitive time-resolved immunofluorometric assay. Pediatr Res. 27:215-219.
18. Backstrom CT, McNeilly AS, Leask RM, Baird DT. 1982 Pulsatile secretion of LH, FSH, prolactin, oestradiol and progesterone during the human menstrual cycle. Clin Endocrinol (Oxf). 16:29-42.
19. Parker DC, Judd HL, Rossmann LG, Yen SSC. 1975 Pubertal sleep-wake patterns of episodic LH, FSH and testosterone release in twin boys. J Clin Endocrinol Metab. 40:1099-1109.
20. Penny R, Olambiwonnu NO, Frasier SD. 1977 Episodic fluctuations of serum gonadotropins in pre- and post-pubertal girls and boys. J Clin Endocrinol Metab. 45:307-311.
21. Matsumoto AM, Karpas AE, Bremner WJ. 1986 Chronic human chorionic gonadotropin in normal men: evidence that follicle-stimulating hormone is necessary for the maintenance of quantitatively normal spermatogenesis in man. J Clin Endocrinol Metab. 62:1184-1192.
22. Santen RJ. 1975 Is aromatization of testosterone to estradiol required for inhibition of luteinizing hormone secretion in man. J Clin Invest. 56:1555-1563.
23. Veldhuis JD, Iranmanesh A, Urban RJ. Primary gonadal failure in men selectively increases the mass of follicle stimulating hormone (FSH) secreted per burst. Proc of the 24th Annual Meet of the American Soc of Androl. 1993 (Abstract 27).
24. Shecker CB, Matsumoto AM, Bremner WJ. 1989 Testosterone administration inhibits gonadotropin secretion by an effect directly on the human pituitary J Clin Endocrinol Metab. 68:397-401.
25. Hassing JM, Padmanabhan V, Kelch RP, et al. 1990 Differential regulation of serum immunoreactiveiuteinizing hormone and bioactive follicle-stimulating hormone by testosterone in early pubertal boys. J Clin Endocrinol Metab. 70:1082-1089.
26. Valk TW, Corley KP, Kelch RP, Marshall JC 1981 Pulsatile gonadotropin releasing hormone in gonadotropin deficient and normal men: suppression of follilce-stimulating hormone responses by testosterone. J Clin Endocrinol Metab. 53:184-191.
27. Capell PT, Paulsen CA, Derleth D, Skoglund R, Plymate S. 1973 The effect of short-term testosterone administration on serum FSH, LH and testosterone levels: evidence for selective abnormality in LH control in patients with Klinefelter's syndrome. J Clin Endocrinol Metab. 37:752-760.
28. Winters SJ. 1994 FSH is produced by GnRH-deficient men and is suppressed by testosterone. J Androl. 15:216-219.
29. Matsumoto AM. 1990 Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production. J Clin Endocrinol Metab. 70:282-286.
30. Bagatell CJ, Dahl KD, Bremner WJ. 1994 The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol. J Androl. 15:15-21.
31. Sherins RJ, Loriaux DL. 1973 Studies on the role of sex steroids in the feedback control of FSH concentrations in men. J Clin Endocrinol Metab. 36:886-893.
32. Tenover JS, Dahl KD, Hsueh AJ, Lim P, Matsumoto AM, Bremner WJ. 1987 Serum bioactive and immunoreactive follicle-stimulating hormone levels and the response to clomiphene in healthy young and elderly men. J Clin Endocrinol Metab. 64:1103-1108.
33. Urban RJ, Padmanabhan V, Beitins I, Veldhuis JD. 1991 Metabolic clearance of human follicle-stimulating hormone assessed by radioimmunoassay, immunoradiometric assay, and in vitro Sertoli cell bioassay. J Clin Endocrinol Metab. 73:818-823.
34. Zwart AD, Urban RJ, Odell WD, Veldhuis JD. 1996 Contrasts in the gonadotropin-releasing dose-response relationships for luteinizing hormone, follicle-stimulating hormone, and α-subunit release in young PS. older men: appraisal with high-specificity immunoradiometric assay and deconvolution analysis. Eur J Endocrinol. 135:399-406.
35. Reyes Fuentes A, Chavarria ME, Carrera A, et al. 1996 Combined alterations in pulsatile LH and FSH secretion in idiopathic oligospermic men: assessment by deconvolution analysis. J Clin Endocrinol Metab. 81:524-529.
36. Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, Veldhuis JD. 1988 Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev. 9:3-37.
37. Veldhuis JD, Rogol AD, Samojlik E, Ertel N. 1984 Role of endogenous opiates in the expression of negative feedback actions of estrogen and androgen on pulsatile properties of luteinizing hormone secretion in man. J Clin Invest. 74:47-55.
38. Veldhuis JD, Evans WS, Rogol AD, Kolp L, Thomer MO, Stumpf P. 1986 The pituitary self-priming actions of gonadotropin-releasing hormone: kinetics of estradiol's potentiating effects on GnRH-facilitated LH and FSH release in healthy post-menopausal women. J Clin Invest. 77:1849-1856.
39. Veldhuis JD, Wilkowski MJ, Urban RJ, Lizarralde G, Iranmanesh A, Bolton WK. 1993 Evidence for attenuation of hypothalamic GnRH impulse strength with preservation of gonadotropin-releasing hormone (GnRH) pulse frequency in men with chronic renal failure. J Clin Endocrinol Metab. 76:648-654.
40. Veldhuis JD, Carlson ML, Johnson ML. 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA. 84:7686-7690.
41. Veldhuis JD, Johnson ML. 1992 Deconvolution analysis of hormone data. Methods Enzymol. 210:539-575.
42. Veldhuis JD, Johnson ML. 1995 Specific methodological approaches to selected contemporary issues in deconvotution analysis of pulsatile neuroendocrine data. Methods Neurosci. 28:25-92.
43. Samuels MH, Veldhuis JD, Cawley C, et al. 1993 Pulsatile secretion of parathyroid hormone in normal young subjects: assessment by deconvolution analysis. J Clin Endocrinol Metab. 76:399-403.
44. Urban RJ, Veldhuis JD. 1988 Hypothalamo-pituitary concomitants of aging. In: Sowers JR, Felicetta JV, eds. The endocrinology of aging. New York: Raven Press; 41-74.
45. Harman SM, Tsitouras PD, Costa PT, Blackman MR. 1982 Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. J Clin Endocrinol Metab. 54:547-551.
46. Tenover JS, McLachlan RI, Dahl KD, Burger HG, de Kretser DM, Bremner WJ. 1988 Decreased serum inhibin levels in normal elderly men: evidence for a decline in Sertoli cell function with aging. J Clin Endocrinol Metab. 67:455-461.
47. Winters SJ, Troen P. 1982 Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab. 55:560-565.
48. Wide L, Wide M. 1984 Higher plasma disappearance rate in the mouse for pituitary follicle-stimulating hormone of the young women compared to that of men and elderly women. J Clin Endocrinol Metab. 54:426-429.
49. Wide L. 1986 The regulation of metabolic clearance rate of human FSH in mice by variation of the molecular structure of the hormone. Acta Endocrinol (Copenh). 112:336-344.
50. Ulloa-Aguirre A, Coutifaris C. 1983 Biosynthesis and secretion of follicle-stimulating hormone. Endocr Rev. 4:179-211.
51. Veldhuis JD, Urban RJ, Beitins I, Blizzard RM, Johnson ML, Dufau ML. 1989 Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man. J Steroid Biochem. 33:739-750.
52. Veldhuis JD, Lassiter AB, Johnson ML. 1990 Operating behavior of dual or multiple endocrine pulse generators. Am J Physiol 259:E351-E361.
53. Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD. 1995 Amplified nocturnal luteinizing hormone (LH) secretory burst frequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aged men: possible Leydig cell desensitization to endogenous LH signaling-a clinical research center study. J Clin Endocrinol Metab. 80:3025-3031.
54. Kotsuji F, Winters SJ, Attardi B, Keeping HS, Oshima H, Troen P. 1988 Effects of gonadal steroids on gonadotropin secretion in males: studies with perifused rat pituitary cells. Endocrinology. 123:2683-2689.
55. Farnworth PG. 1995 Gonadotropin secretion revisited. How many ways can FSH leave a gonadotroph? J Endocrinol. 145:387-395.
56. Alexander SL, Irvine CHG. 1987 Secretion rates and short-term patterns of gonadotropin-releasing hormone, FSH and LH throughout the preovulatory period in the mare. J Endocrinol. 114:351-362.
57. Veldhuis JD, Fraioli F, Rogol AD, Dufau ML. 1986 Metabolic clearance of biologically active luteinizing hormone in man. J Clin Invest. 77:1122-1128.
58. Pepperell RJ, de Kretser DM, Burger HG. 1975 Studies on the metabolic clearance rate and production rate of human luteinizing hormone and on the initial half-life of its subunits in man. J Clin Invest. 56:118-126.
59. Yen SS, Llerena LA, Pearson OH, Littell AS. 1970 Disappearance rates of endogenous follicle-stimulating hormone in serum following surgical hypophysectomy in man. J Clin Endocrinol Metab. 30:325-329.
60. Coble Jr YD, Kohler PO, Caigille CM, Ross GT. 1969 Production rates and metabolic clearance rates of human follicle-stimulating hormone in premenopausal and postmenopausal women. J Clin Invest. 48:359-363.
61. Amin HK, Hunter WM. 1970 Human pituitary follicle-stimulating hormone: distribution, plasma clearance and urinary excretion as determined by radio-immunoassay. J Endocrinol. 48:307-317.
62. Davis MR, Veldhuis JD, Rogol AD, Dufau ML, Catt KJ. 1987 Sustained inhibitory actions of a potent antagonist of gonadotropin-releasing hormone in postmenopausal women. J Clin Endocrinol Metab. 64:1268-1274.
63. Urban RJ, Pavlou SN, Rivier JE, Vale WW, Dufau ML, Veldhuis JD. 1990 Suppressive actions of a gonadotropin-releasing hormone (GnRH) antagonist on LH, FSH, and prolactin release in estrogen-deficient postmenopausal women. Am J Obstet Gynecol. 162:1255-1260.
64. KoIp LA, Pavlou SN, Urban RJ, Rivier JC, Vale WW, Veldhuis JD. 1992 Abrogation by a potent GnRH antagonist of the estrogen/progesterone-stimulated surge-like release of LH and FSH in postmenopausal women. J Clin Endocrinol Metab. 75:993-997.
65. Mortola JF, Sathanandan M, Pavlou S. 1989 Suppression of bioactive and immunoassay follicle-stimulating hormone and luteinizing hormone levels by a potent gonadotropin-releasing hormone antagonist: pharmacodynamic studies. Fertil Steril. 51:957-963.
66. Kartun K, Schwartz NB. 1987 Effects of a potent antagonist to gonadotropin-releasing hormone on male rats: luteinizing hormone is suppressed more than follicle-simulating hormone. Biol Reprod. 36:103-108.
67. Kotsuji F, Winters SJ, keeping HS, Attatdi B, Oshima H, Troen P. 1988 Effects of inhibin from primate Sertoli cells on follicle stimulating hormone and luteinizing hormone release by perifused rat pituitary cells. Endocrinology. 122:2796-2802.
68. McLachlan RI, Dahl KD, Bremner WJ, et al. 1989 Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis. Endocrinology. 125:2787-2789.
69. Gross KM, Matsumoto AM, Bremner WJ. 1987 Differential control of luteinizing hormone and follicle stimulating hormone secretion by luteinizing hormone-releasing hormone pulse frequency in man. J Clin Endocrinol Metab. 64:675-680.
70. Medhamurthy R, Culler MD, Gay VL, Negro-Vilar A, Plant TM. 1991 Evidence that inhibin plays a major role in the regulation of follicle-stimulating hormone secretion in the fully adult male rhesus monkey (Macaca mulatta). Endocrinology. 129:389-395.
71. Ying S. 1988 Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of FSH. Endocr Rev. 9:267.
72. Kumar RT, Malcolm LJ. 1995 Hormonal regulation of human follicle-stimulating hormone-B subunit gene expression: GnRH stimulation and GnRH-independent androgen inhibition. Neuroendocrinology. 61:628-637.
73. Johnson ML, Veldhuis JD. 1995 Evolution of deconvolution analysis as a hormone pulse detection method. Methods Neurosci. 28:1-24.
74. Veldhuis JD, Evans WS, Johnson ML. 1995 Complicating effects of highly correlated model variables on nonlinear least-squares estimates of unique parameter values and their statistical confidence intervals: estimating basal secretion and neurohormone half-life by deconvolution analysis. Methods Neurosci. 28:130-138.
75. Veldhuis JD, Liem AY, South S, et al. 1995 Differential impact of age, sex-steroid hormones, and obesity on basal vs. pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 80:3209-3222.
76. Porksen N, Munn S, Steers J, Veldhuis JD, Butler P. 1995 Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and Cluster analysis. Am J Physiol. 269:E1106-E1114.