GH and IGF-I increase leptin receptor expression in prepubertal pig ovaries: The role of leptin in steroid secretion and cell apoptosis

Acta Veterinaria Hungarica

Volumn 54, Issue 3, 2006, Pages 413-426

  Gregoraszczuk, Ewa L ^a   Rak, Agnieszka ^a   Wójtowicz, Anna ^a   Ptak, Anna ^c   Wojciechowicz, Tatiana ^b   Nowak, K W ^b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

^c NONE

Author keywords

Apoptosis; GH; IGF I; Leptin; Leptin receptor expression; Prepubertal ovary

Indexed keywords

CELL SURFACE RECEPTOR; ESTRADIOL; GROWTH HORMONE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PROGESTERONE; SOMATOMEDIN C;

ANIMAL; ANIMAL DISEASE; APOPTOSIS; ARTICLE; DOSE RESPONSE; DRUG EFFECT; ESTRUS CYCLE; FEMALE; METABOLISM; OVARY; OVARY FOLLICLE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; SWINE;

ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROUS CYCLE; FEMALE; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; OVARIAN FOLLICLE; OVARY; PROGESTERONE; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE;

ANIMALIA; SUS SCROFA;

EID: 33747661050     PISSN: 02366290     EISSN: 15882705     Source Type: Journal    
DOI: 10.1556/AVet.54.2006.3.12     Document Type: Article

References (38)

1. Agarwal, S. K., Vogel, K., Weitsman, S. R. and Magoffin, D. A. (1999): Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J. Clin. Endocrinol. metab. 84, 1072-1076.
2. Almog, B., Gold, R., Tajima, K., Dantes, A., Salim, K, Rubinstein, M., Barkan, D., Homburg, R., Lessing, J. B., Nevo, N., Gertler, A. and Amsterdam, A. (2001): Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. Mol. Cell. Endocrinol. 183, 179-191.
3. Apter, D. (2000): Leptin and puberty. Current Opinion in Endocrinology and Diabetes 7, 57-64.
4. Arslanian, S., Suprasongsin, C., Kalhan, S. C., Drash, A. L., Brna, R. and Janosky, J. E. (1998): Plasma leptin in children, relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure. Metabolism 47, 309-312.
5. Barkan, D., Jia, H., Dantes, A., Vardimon, L., Amsterdam, A. and Rubinstein, M. (1999): Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. Endocrinology 140, 1731-1738.
6. Boone, D. L. and Tsang, B. K. (1998): Caspase-3 in the rat ovary, localization and possible role in follicular atresia and luteal regression. Biol. Reprod. 58, 1533-1539.
7. Bourguignon, J. P., Gerard, A., Fawe, L., Alvarez-Gonzalez, M. L. and Franchimont, P. (1991): Neuroendocrine control of the onset of puberty, secretion of gonadotrophin-releasing hormone from rat hypothalamic explants. Acta Paediatr. Scand. Suppl. 372, 19-25.
8. Brannian, J. D., Zhao, Y. and McElroy, M. (1999): Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action. Hum. Reprod. 14, 1445-1448.
9. Demerath, E. W., Towne, B., Wisemandle, W., Blangero, J., Chumlea, W. C. and Siervogel, R. M. (1999): Serum leptin concentration, body composition, and gonadal hormones during puberty. Int. J. Obes. Relat. Metab. Disord. 23, 678-685.
10. Elimam, A., Lindgren, A. C., Norgren, S., Kamel, A., Skwirut, C., Bang, P. and Marcus, C. (1999): Growth hormone treatment downregulates serum leptin levels in children independent of changes in body mass index. Horm. Res. 52, 66-72.
11. Fine, M., Amuly, R., Sandowski, Y., Marchant, T. A., Chan, S. J., Gertler, A. and Funkenstein, B. (1997): Recombinant gilthead seabream (Sparus aurata) insulin-like growth factor-I: sub-cloning, expression in Escherichia coli, purification and characterization. J. Endocrinol. 153, 139-150.
12. Gertler, A., Simmons, J. and Keisler, D. H. (1998): Large-scale preparation of biologically active recombinant ovine obese protein (leptin). FEBS Lett, 422, 137-140.
13. Gougeon, A. (1996): Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr. Rev. 17, 121-155.
14. Gregoraszczuk, E. L., Bylica, A. and Gertler, A. (2000): Response of porcine theca and granulosa cells to GH during short-term in vitro culture. Anim. Reprod. Sci. 58, 113-125.
15. Gregoraszczuk, E. L., Wojtowicz, A. K., Ptak, A. and Nowak, K. (2003): In vitro effect of leptin on steroids' secretion by FSH- and LH-treated porcine small, medium and large preovulatory follicles. Reprod. Biol. 3, 227-239.
16. Hamm, M. L., Bhat, G. K., Thompson, W. E. and Mann, D. R. (2004): Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice. Biol. Reprod. 71, 66-72.
17. Hardie, L. J., Rayner, D. V., Holmes, S. and Trayhurn, P. (1996): Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem. Biophys. Res. Commun. 25, 660-665.
18. Herman, A., Helman, D., Livnah, O. and Gertler, A. (1999): Ruminant placental lactogens act as antagonists to homologous growth hormone receptors and as agonists to human or rabbit growth hormone receptors. J. Biol. Chem. 274, 7631-7639.
19. Hiney, J. K., Srivastava, V., Nyberg, C. L., Ojeda, S. R. and Dees, W. L. (1996): Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinology 137, 3717-3728.
20. Kiess, W., Blum, W. F. and Aubert, M. L. (1998): Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur. J. Endocrinol. 138, 26-29.
21. Kim, J. M, Yoon, Y. D. and Tsang, B. K. (1999): Involvement of the Fas/Fas ligand system in p53-mediated granulosa cell apoptosis during follicular development and atresia. Endocrinology 140, 2307-2317.
22. Kołodziejczyk, J., Gregoraszczuk, E. L., Leibovich, H. and Gertler, A. (2001): Different action of ovine GH on porcine theca and granulosa cells proliferation and insulin-like growth factors I- and II-stimulated estradiol production. Reprod. Biol. 1, 33-41.
23. Kołodziejczyk, J., Gertler, A., Leibovich, H., Rzasa, J. and Gregoraszczuk, E. L. (2003): Synergistic action of growth hormone and insulin-like growth factor I (IGF-I) on proliferation and estradiol secretion in porcine granulosa and theca cells cultured alone or in coculture. Theriogenology 60, 559-570.
24. Leung, K. C., Johannsson, G., Leong, G. M. and Ho, K. K. (2004): Estrogen regulation of growth hormone action. Endocr. Rev. 25, 693-721.
25. Lin, J., Richard Barb, C., Kraeling, R. R. and Rampacek, G. B. (2001): Developmental changes in the long form leptin receptor and related neuropeptide gene expression in the pig brain. Biol. Reprod. 64, 1614-1618.
26. Link, K., Blizzard R. M., Evans, W. S., Kaiser, D. L., Parker, M. W. and Rogol, A. D. (1986): The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males. J. Clin. Endocrinol. Metab. 62, 159-164.
27. Mannucci, E., Ognibene, A., Becorpi, A., Cremaso, F., Pellegrini, S., Ottanelli, S., Rizzello, S. M., Massi, G., Messer, G. and Rotella, C. M. (1998): Relationship between leptin and oestrogens in healthy women. Europ. J. Endocrinol. 139, 198-201.
28. Matikainen, T., Perez, G. I., Zheng, T. S., Kluzak, T. R., Rueda, B. R., Flavell, R. A. and Tilly, J. L. (2001): Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology 142, 2468-2480.
29. Mauras, N., Blizzard, R. M., Link, K., Johnson, M. L., Rogol, A. D. and Veldhuis, J. D. (1987): Augmentation of growth hormone secretion during puberty, evidence for a pulse amplitude-modulated phenomenon. J. Clin. Endocrinol. Metab. 64, 596-601.
30. Peri, I., Shamay, A., McGranth, M. F., Collier, R. J. and Gertler, A. (1992): Comparative mitogenic and galactopoietic effects of IGF-I IGF-II and Des-3-IGF-I in bovine mammary gland in vitro. Cell. Biol. Int. Rep. 16, 359-368.
31. Plant, T. M., Gay, V. L., Marshall, G. R. and Arslan, M. (1989): Puberty in monkeys is triggered by chemical stimulation of the hypothalamus. Proc. Natl. Acad. Sci. U S A. 86, 2506-2510.
32. Quirk, S. M., Cowan, R. G., Joshi, S. G. and Henrikson, K. P. (1995): Fas antigen-mediated apoptosis in human granulosa/luteal cells. Biol. Reprod. 52, 279-287.
33. Spicer, L. J. and Francisco, C. C. (1997): The adipose obese gene product, leptin, evidence of a direct inhibitory role in ovarian function. Endocrinology 138, 3374-3379.
34. Spicer, L. J and Francisco, C. C. (1998): Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol. Reprod. 58, 207-212.
35. Suter, K. J., Pohl, C. R. and Wilson, M. E. (2000): Circulating concentrations of nocturnal leptin, growth hormone, and insulin-like growth factor-I increase before the onset of puberty in agonadal male monkeys, potential signals for the initiation of puberty. J. Clin. Endocrinol. Metab. 85, 808-814.
36. Svensson, J., Herlitz, H., Lundberg, P. A. and Johannsson, G. (2005): Adiponectin, leptin, and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient adults. J. Clin. Endocrinol. Metab. 90, 2290-2296.
37. Zachow, R. J. and Magoffin, D. A. (1997): Direct intraovarian effects of leptin, impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology 138, 847-850.
38. Zachow, R. J., Weitsman, S. R. and Magoffin, D. A. (1999): Leptin impairs the synergistic stimulation by transforming growth factor-beta of follicle-stimulating hormone-dependent aromatase activity and messenger ribonucleic acid expression in rat ovarian granulosa cells. Biol. Reprod. 61, 1104-1109.