Prevention of postoperative nausea and vomiting by metoclopramide combined with dexamethasone: Randomised double blind multicentre trial

British Medical Journal

Volumn 333, Issue 7563, 2006, Pages 324-327

  Wallenborn, Jan ^a   Gelbrich, Götz ^a   Bulst, Detlef ^b   Behrends, Katrin ^a   Wallenborn, Hasso ^c   Rohrbach, Andrea ^a   Krause, Uwe ^d   Kühnast, Thomas ^e   Wiegel, Martin ^a   Olthoff, Derk ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Bad Düben Forest Hospital   (Germany)

^c Wurzen District Hospital   (Germany)

^d Grimma District Hospital   (Germany)

^e Weissenfels District Hospital   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; METOCLOPRAMIDE; ANTIEMETIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; HYPOTENSION; INCIDENCE; MAJOR CLINICAL STUDY; META ANALYSIS; MULTICENTER STUDY; NAUSEA AND VOMITING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGERY; SYSTEMATIC REVIEW; TACHYCARDIA; DRUG COMBINATION; FEMALE; MALE; MIDDLE AGED; PEROPERATIVE CARE; POSTOPERATIVE NAUSEA AND VOMITING;

ADULT; ANTIEMETICS; DEXAMETHASONE; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INTRAOPERATIVE CARE; MALE; METOCLOPRAMIDE; MIDDLE AGED; POSTOPERATIVE NAUSEA AND VOMITING;

EID: 33747615444     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.38903.419549.80     Document Type: Article

References (8)

1. Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004;350:2441-51.
2. Henzi I, Walder B, Tramer MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized, placebo-controlled studies. Br J Anaesth 1999;83:761-71.
3. Olthoff D. Antiemetika. In: Olthoff D, ed. Arzneimittelanwendungen in der Anästhesie. Stuttgart: Wissenschaftliche Verlagsgesellschaft, 2003:511-34.
4. Flather MD, Farkouh ME, Pogue JM, Yusuf S. Strengths and limitations of meta-analysis: larger studies may be more reliable. Control Clin Trials 1997;18:568-79.
5. Apfel CC, Kranke P, Katz MH, Goepfert C, Papenfuss T, Rauch S, et al. Volatile anaesthetics may be the main cause of early but not delayed vomiting: a randomized controlled trial of factorial design. Br J Anaesth 2002;88:659-68.
6. Eberhart LHJ, Seeling W, Ulrich B, Morin AM, Georgieff M. Dimenhydrinate and metoclopramide alone or in combination for prophylaxis of PONV. Can J Anesth 2000;47:780-5.
7. Piper SN, Suttner SW, Röhm KD, Maleck WH, Larbig E, Boldt J. Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Can J Anesth 2002;49:1021-8.
8. Quaynor H, Ræder JC. Incidence and severity of postoperative nausea and vomiting are similar after metoclopramide 20 mg and ondansetron 8 mg given by the end of laparoscopic cholecystectomies. Acta Anaesthesiol Scand 2002;46:109-13.