메뉴 건너뛰기




Volumn 17, Issue 6, 2006, Pages 631-639

Imatinib activity in vitro in tumor cells from patients with chronic myeloid leukemia in chronic phase and blast crisis

Author keywords

Chronic myeloid leukemia; Drug combinations; Fluorometric microculture cytotoxicity assay; Imatinib mesylate; In vitro drug sensitivity

Indexed keywords

AMSACRINE; ARSENIC TRIOXIDE; CISPLATIN; CLADRIBINE; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; HOMOHARRINGTONINE; IDARUBICIN; IMATINIB; INTERFERON; MELPHALAN; MITOXANTRONE; PREDNISOLONE; TIOGUANINE; VINCRISTINE;

EID: 33747605541     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cad.0000217423.59831.db     Document Type: Article
Times cited : (4)

References (47)
  • 2
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 1985; 315:550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 4
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 6
    • 0028283040 scopus 로고
    • Autologous transplants for chronic myelogenous leukaemia: Results from eight transplant groups
    • McGlave PB, De Fabritiis P, Deisseroth A, Goldman J, Barnett M, Reiffers J, et al. Autologous transplants for chronic myelogenous leukaemia: results from eight transplant groups. Lancet 1994; 343:1486-1488.
    • (1994) Lancet , vol.343 , pp. 1486-1488
    • McGlave, P.B.1    De Fabritiis, P.2    Deisseroth, A.3    Goldman, J.4    Barnett, M.5    Reiffers, J.6
  • 8
    • 0030839045 scopus 로고    scopus 로고
    • Optimizing treatment for chronic myeloid leukemia
    • Goldman JM. Optimizing treatment for chronic myeloid leukemia. N Engl J Med 1997; 337:270-271.
    • (1997) N Engl J Med , vol.337 , pp. 270-271
    • Goldman, J.M.1
  • 9
    • 20844454084 scopus 로고    scopus 로고
    • Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: Long-term follow-up
    • Simonsson B, Oberg G, Bjoreman M, Bjorkholm M, Carneskog J, Karlsson K, et al. Intensive treatment and stem cell transplantation in chronic myelogenous leukemia: long-term follow-up. Acta Haematol 2005; 113:155-162.
    • (2005) Acta Haematol , vol.113 , pp. 155-162
    • Simonsson, B.1    Oberg, G.2    Bjoreman, M.3    Bjorkholm, M.4    Carneskog, J.5    Karlsson, K.6
  • 10
    • 23444462074 scopus 로고
    • Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia
    • The Italian cooperative study group on chronic myeloid leukemia. Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med 1994; 330:820-825.
    • (1994) N Engl J Med , vol.330 , pp. 820-825
  • 11
    • 0029041749 scopus 로고
    • UK Medical Research Council randomised, multicentre trial of interferon-alpha n1 for chronic myeloid leukaemia: Improved survival irrespective of cytogenetic response
    • The UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia
    • Allan NC, Richards SM, Shepherd PC. UK Medical Research Council randomised, multicentre trial of interferon-alpha n1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response. The UK Medical Research Council's Working Parties for Therapeutic Trials in Adult Leukaemia. Lancet 1995; 345:1392-1397.
    • (1995) Lancet , vol.345 , pp. 1392-1397
    • Allan, N.C.1    Richards, S.M.2    Shepherd, P.C.3
  • 12
    • 0025854383 scopus 로고
    • Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia. Philadelphia chromosome-positive patients
    • Talpaz M, Kantarjian H, Kurzrock R, Trujillo JM, Gutterman JU. Interferon-alpha produces sustained cytogenetic responses in chronic myelogenous leukemia. Philadelphia chromosome-positive patients. Ann Intern Med 1991; 114:532-538.
    • (1991) Ann Intern Med , vol.114 , pp. 532-538
    • Talpaz, M.1    Kantarjian, H.2    Kurzrock, R.3    Trujillo, J.M.4    Gutterman, J.U.5
  • 13
    • 0028170517 scopus 로고
    • Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia
    • The German CML Study Group
    • Hehlmann R, Heimpel H, Hasford J, Kolb HJ, Pralle H, Hossfeld DK, et al. Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML Study Group. Blood 1994; 84:4064-4077.
    • (1994) Blood , vol.84 , pp. 4064-4077
    • Hehlmann, R.1    Heimpel, H.2    Hasford, J.3    Kolb, H.J.4    Pralle, H.5    Hossfeld, D.K.6
  • 14
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Regenass U, et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci U S A 1995; 92:2558-2562.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2558-2562
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Regenass, U.6
  • 15
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, Druker BJ, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 1996; 56:100-104.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5    Druker, B.J.6
  • 17
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, Goldman JM, Gambacorti-Passerini C, Guilhot F, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 2002; 99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3    Goldman, J.M.4    Gambacorti-Passerini, C.5    Guilhot, F.6
  • 18
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3    Gathmann, I.4    Baccarani, M.5    Cervantes, F.6
  • 19
    • 0034330931 scopus 로고    scopus 로고
    • Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells
    • Thiesing JT, Ohno-Jones S, Kolibaba KS, Druker BJ. Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells. Blood 2000; 96:3195-3199.
    • (2000) Blood , vol.96 , pp. 3195-3199
    • Thiesing, J.T.1    Ohno-Jones, S.2    Kolibaba, K.S.3    Druker, B.J.4
  • 20
    • 0037094118 scopus 로고    scopus 로고
    • In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells
    • Scappini B, Onida F, Kantarjian HM, Dong L, Verstovsek S, Keating MJ, et al. In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells. Cancer 2002; 94:2653-2662.
    • (2002) Cancer , vol.94 , pp. 2653-2662
    • Scappini, B.1    Onida, F.2    Kantarjian, H.M.3    Dong, L.4    Verstovsek, S.5    Keating, M.J.6
  • 21
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977; 197:461-463.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 22
    • 0020655495 scopus 로고
    • Comparison of dye exclusion assays with a clonogenic assay in the determination of drug-induced cytotoxicity
    • Weisenthal LM, Dill PL, Kurnick NB, Lippman ME. Comparison of dye exclusion assays with a clonogenic assay in the determination of drug-induced cytotoxicity. Cancer Res 1983; 43:258-264.
    • (1983) Cancer Res , vol.43 , pp. 258-264
    • Weisenthal, L.M.1    Dill, P.L.2    Kurnick, N.B.3    Lippman, M.E.4
  • 23
    • 0021802941 scopus 로고
    • Clonogenic and nonclonogenic in vitro chemosensitivity assays
    • Weisenthal LM, Lippman ME. Clonogenic and nonclonogenic in vitro chemosensitivity assays. Cancer Treat Rep 1985; 69:615-632.
    • (1985) Cancer Treat Rep , vol.69 , pp. 615-632
    • Weisenthal, L.M.1    Lippman, M.E.2
  • 24
    • 0026529184 scopus 로고
    • Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA)
    • Larsson R, Kristensen J, Sandberg C, Nygren P. Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA). Int J Cancer 1992; 50:177-185.
    • (1992) Int J Cancer , vol.50 , pp. 177-185
    • Larsson, R.1    Kristensen, J.2    Sandberg, C.3    Nygren, P.4
  • 25
    • 0026498806 scopus 로고
    • Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia
    • Nygren P, Kristensen J, Jonsson B, Sundstrom C, Lonnerholm G, Kreuger A, et al. Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia. Leukemia 1992; 6:1121-1128.
    • (1992) Leukemia , vol.6 , pp. 1121-1128
    • Nygren, P.1    Kristensen, J.2    Jonsson, B.3    Sundstrom, C.4    Lonnerholm, G.5    Kreuger, A.6
  • 26
    • 0027976207 scopus 로고
    • In vitro drug sensitivity testing of tumor cells from patients with non-Hodgkin's lymphoma using the fluorometric microculture cytotoxicity assay
    • Nygren P, Hagberg H, Glimelius B, Sundstrom C, Kristensen J, Christiansen I, et al. In vitro drug sensitivity testing of tumor cells from patients with non-Hodgkin's lymphoma using the fluorometric microculture cytotoxicity assay. Ann Oncol 1994; 5 (Suppl 1):127-131.
    • (1994) Ann Oncol , vol.5 , Issue.1 SUPPL. , pp. 127-131
    • Nygren, P.1    Hagberg, H.2    Glimelius, B.3    Sundstrom, C.4    Kristensen, J.5    Christiansen, I.6
  • 27
    • 0042629669 scopus 로고    scopus 로고
    • Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia
    • Frost BM, Nygren P, Gustafsson G, Forestier E, Jonsson OG, Kanerva J, et al. Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia. Br J Haematol 2003; 122:376-385.
    • (2003) Br J Haematol , vol.122 , pp. 376-385
    • Frost, B.M.1    Nygren, P.2    Gustafsson, G.3    Forestier, E.4    Jonsson, O.G.5    Kanerva, J.6
  • 28
    • 0035080416 scopus 로고    scopus 로고
    • Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells
    • Topaly J, Zeller WJ, Fruehauf S. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 2001; 15:342-347.
    • (2001) Leukemia , vol.15 , pp. 342-347
    • Topaly, J.1    Zeller, W.J.2    Fruehauf, S.3
  • 29
    • 0035313251 scopus 로고    scopus 로고
    • In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents
    • Kano Y, Akutsu M, Tsunoda S, Mano H, Sato Y, Honma Y, et al. In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents. Blood 2001; 97:1999-2007.
    • (2001) Blood , vol.97 , pp. 1999-2007
    • Kano, Y.1    Akutsu, M.2    Tsunoda, S.3    Mano, H.4    Sato, Y.5    Honma, Y.6
  • 30
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65:4500-4505.
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3    Jia, T.4    Manley, P.W.5    Mestan, J.6
  • 31
    • 0033911748 scopus 로고    scopus 로고
    • Manifold-assisted reverse transcription-PCR with real-time detection for measurement of the BCR-ABL fusion transcript in chronic myeloid leukemia patients
    • Barbany G, Hagberg A, Olsson-Stromberg U, Simonsson B, Syvanen AC, Landegren U. Manifold-assisted reverse transcription-PCR with real-time detection for measurement of the BCR-ABL fusion transcript in chronic myeloid leukemia patients. Clin Chem 2000; 46:913-920.
    • (2000) Clin Chem , vol.46 , pp. 913-920
    • Barbany, G.1    Hagberg, A.2    Olsson-Stromberg, U.3    Simonsson, B.4    Syvanen, A.C.5    Landegren, U.6
  • 32
    • 0027132725 scopus 로고
    • Prediction of individual patient response to chemotherapy by the fluorometric microculture cytotoxicity assay (FMCA) using drug specific cut-off limits and a Bayesian model
    • Larsson R, Nygren P. Prediction of individual patient response to chemotherapy by the fluorometric microculture cytotoxicity assay (FMCA) using drug specific cut-off limits and a Bayesian model. Anticancer Res 1993; 13:1825-1829.
    • (1993) Anticancer Res , vol.13 , pp. 1825-1829
    • Larsson, R.1    Nygren, P.2
  • 33
    • 0025126372 scopus 로고
    • Chemotherapeutic drug sensitivity testing of human leukemia cells in vitro using a semiautomated fluorometric assay
    • Larsson R, Nygren P, Ekberg M, Slater L. Chemotherapeutic drug sensitivity testing of human leukemia cells in vitro using a semiautomated fluorometric assay. Leukemia 1990; 4:567-571.
    • (1990) Leukemia , vol.4 , pp. 567-571
    • Larsson, R.1    Nygren, P.2    Ekberg, M.3    Slater, L.4
  • 34
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 35
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
    • Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979; 5:85-91.
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 36
    • 0035543193 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization: A highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias
    • Amare PS, Baisane C, Saikia T, Nair R, Gawade H, Advani S. Fluorescence in situ hybridization: a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias. Cancer Genet Cytogenet 2001; 131:125-134.
    • (2001) Cancer Genet Cytogenet , vol.131 , pp. 125-134
    • Amare, P.S.1    Baisane, C.2    Saikia, T.3    Nair, R.4    Gawade, H.5    Advani, S.6
  • 37
    • 0033105697 scopus 로고    scopus 로고
    • Relationship between diagnosis-specific activity of cytotoxic drugs in fresh human tumour cells ex vivo and in the clinic
    • Fridborg H, Jonsson E, Nygren P, Larsson R. Relationship between diagnosis-specific activity of cytotoxic drugs in fresh human tumour cells ex vivo and in the clinic. Eur J Cancer 1999; 35:424-432.
    • (1999) Eur J Cancer , vol.35 , pp. 424-432
    • Fridborg, H.1    Jonsson, E.2    Nygren, P.3    Larsson, R.4
  • 38
    • 0030914996 scopus 로고    scopus 로고
    • Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients
    • Jonsson E, Fridborg H, Csoka K, Dhar S, Sundstrom C, Nygren P, et al. Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients. Br J Cancer 1997; 76:211-219.
    • (1997) Br J Cancer , vol.76 , pp. 211-219
    • Jonsson, E.1    Fridborg, H.2    Csoka, K.3    Dhar, S.4    Sundstrom, C.5    Nygren, P.6
  • 39
    • 9444248149 scopus 로고    scopus 로고
    • VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia
    • Aleskog A, Tobin G, Laurell A, Thunberg U, Lindhagen E, Roos G, et al. VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia. Eur J Haematol 2004; 73:407-411.
    • (2004) Eur J Haematol , vol.73 , pp. 407-411
    • Aleskog, A.1    Tobin, G.2    Laurell, A.3    Thunberg, U.4    Lindhagen, E.5    Roos, G.6
  • 40
    • 22144469478 scopus 로고    scopus 로고
    • In vitro activity of the flt3-inhibitor SU5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia
    • Aleskog A, Hoglund M, Pettersson J, Hermansson M, Larsson R, Lindhagen E. In vitro activity of the flt3-inhibitor SU5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia. Leuk Res 2005; 29:1079-1081.
    • (2005) Leuk Res , vol.29 , pp. 1079-1081
    • Aleskog, A.1    Hoglund, M.2    Pettersson, J.3    Hermansson, M.4    Larsson, R.5    Lindhagen, E.6
  • 41
  • 42
    • 0034667607 scopus 로고    scopus 로고
    • Cellular drug resistance profiles in childhood acute myeloid leukemia: Differences between FAB types and comparison with acute lymphoblastic leukemia
    • Zwaan CM, Kaspers GJ, Pieters R, Ramakers-Van Woerden NL, den Boer ML, Wunsche R, et al. Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia. Blood 2000; 96:2879-2886.
    • (2000) Blood , vol.96 , pp. 2879-2886
    • Zwaan, C.M.1    Kaspers, G.J.2    Pieters, R.3    Ramakers-Van Woerden, N.L.4    Den Boer, M.L.5    Wunsche, R.6
  • 43
    • 0035992318 scopus 로고    scopus 로고
    • Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
    • Kantarjian HM, O'Brien S, Cortes JE, Smith TL, Rios MB, Shan J, et al. Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate. Clin Cancer Res 2002; 8:2167-2176.
    • (2002) Clin Cancer Res , vol.8 , pp. 2167-2176
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.E.3    Smith, T.L.4    Rios, M.B.5    Shan, J.6
  • 44
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, Ottmann OG, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002; 99:3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3    Goldman, J.M.4    Miller, C.B.5    Ottmann, O.G.6
  • 45
    • 0036940590 scopus 로고    scopus 로고
    • Drug responses of imatinib mesylate-resistant cells: Synergism of imatinib with other chemotherapeutic drugs
    • Tipping AJ, Mahon FX, Zafirides G, Lagarde V, Goldman JM, Melo JV. Drug responses of imatinib mesylate-resistant cells: synergism of imatinib with other chemotherapeutic drugs. Leukemia 2002; 16:2349-2357.
    • (2002) Leukemia , vol.16 , pp. 2349-2357
    • Tipping, A.J.1    Mahon, F.X.2    Zafirides, G.3    Lagarde, V.4    Goldman, J.M.5    Melo, J.V.6
  • 47
    • 0037497182 scopus 로고    scopus 로고
    • Imatinib in combination with cytarabine for the treatment of Philadelphia-positive chronic myelogenous leukemia chronic-phase patients: Rationale and design of phase I/II trials
    • Guilhot F, Gardembas M, Rousselot P, Tulliez M, Vigier M, Buzyn AF, et al. Imatinib in combination with cytarabine for the treatment of Philadelphia-positive chronic myelogenous leukemia chronic-phase patients: rationale and design of phase I/II trials. Semin Hematol 2003; 40:92-97.
    • (2003) Semin Hematol , vol.40 , pp. 92-97
    • Guilhot, F.1    Gardembas, M.2    Rousselot, P.3    Tulliez, M.4    Vigier, M.5    Buzyn, A.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.