Neuroprotective effect of hypothermia on hypoxic-ischemic brain injury in mice

Chinese Journal of Contemporary Pediatrics

Volumn 8, Issue 4, 2006, Pages 315-318

  Wang, Xiao Yang ^a   Zhu, Chang Lian ^a   Xu, Fa Lin ^a   Cheng, Xiu Yong ^a   Qiu, Lin ^a   Hu, Sheng Hai ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cell death; Cerebral hypoxia; Cerebral ischemia; Hypothermia; Mice

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; OXYGEN; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN MATURATION; BRAIN TISSUE; CAROTID ARTERY LIGATION; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; HEMISPHERE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INCUBATION TEMPERATURE; INDUCED HYPOTHERMIA; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; SCORING SYSTEM; TEMPERATURE; THALAMUS; TIME; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; AGE FACTORS; ANIMALS; APOPTOSIS INDUCING FACTOR; BRAIN; CASPASE 3; CASPASES; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 33747592870     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Compagnoni G, Pogliani L, Lista G, Castoldi F, Fontana P, Mosca F. Hypothermia reduces neurological damage in asphyxiated newborn infants[J]. Biol Neonate, 2002, 82(4): 222-227.
2. Battin MR, Dezoete JA, Gunn TR, Gluckman PD, Goon AJ. Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia[J]. Pediatrics, 2001, 107(3): 480-484.
3. Krieger DW, Yenari MA. Therapeutic hypothermia for acute ischemic stroke. What do laboratory studies teach us? [J]. Stroke, 2004, 35(6): 1482-1489.
4. Bernard SA, Buist M. Induced hypothermia in critical care medicine: a review[J]. Crit Care Med, 2003, 31(7): 2041-2051.
5. Chinese source. 2003,5(3):192-196.
6. Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, et al. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia [J]. Cell Death Differ, 2005, 12(2): 162-176.
7. Yager JY, Armstrong EA, Jaharus C, Saucier DM, Wirrell EC. Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures [J]. Brain Res, 2004, 1011 (1): 48-57.
8. Zhu C, Wang X, Xu F, Qiu L, Cheng X, Simbruner G, et al. Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia[J]. Eur J Neurosci, 2006, 23(2): 387-393.
9. Zhu C, Wang X, Cheng X, Qiu L, Xu F, Simbruner G, et al. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia [J]. Brain Res, 2004, 996(1): 67-75.
10. Zhu C, Wang X, Hagberg H, Blomgren K. Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia[J]. J Neurochem, 2000, 75 (2): 819-829.
11. Wang X, Zhu C, Wang X, Hagberg H, KorhonenL, Sandberg M, et al. X-linked inhibitor of apoptosis (XIAP) protein protects against pathological caspase activation and tissue loss after neonatal hypoxia-ischemia[J]. Neurobiol Dis, 2004, 16(1): 179-189.
12. Bona E, Hagberg H, Loberg EM, Bagenholm R, Thoresen M. Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short-and long-term outcome [J]. Pediatr Res, 1998, 43(6): 738-745.
13. Pabello NG, Tracy SJ, Keller RW Jr. Protective effect of brief intra- and delayed postischemic hypothermia in a transient focal ischemia model in the neonatal rat [J]. Brain Res, 2004, 995 (1): 29-38.
14. Van Leeuwen GM, Hand JW, Lagendijk JJ, Azzopardi DV, Edwards AD. Numerical modeling of temperature distributions within the neonatal head[J]. Pediatr Res, 2000, 48(3): 351-356.
15. Dudek H, Datta SR, Franke TF, Brinbaum MJ, Yao R, Cooper GM, et al. Regulation of neuronal survival by serine-threonine protein kinase Akt[J]. Science, 1997, 275(5300): 661-665.
16. Tomimatsu T, Fukuda H, Endo M, Watanabe N, Mu J, Kohzuki M, et al. Effect of hypothermia on neonatal hypoxic-ischemic brain injury in the rat: phosphorylation of Akt, activation of caspase-3-like protease[J]. Neurosci Lett, 2001, 312(1): 21-24.