Oral betamethasone versus intramuscular dexamethasone for the treatment of mild to moderate viral croup: A prospective, randomized trial

Pediatric Emergency Care

Volumn 22, Issue 8, 2006, Pages 541-544

  Amir, Lisa ^a   Hubermann, Henry ^b   Halevi, Ayelet ^b   Mor, Meirav ^b   Mimouni, Marc ^b   Waisman, Yehezkel ^b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b NONE

Author keywords

Betamethasone; Croup; Dexamethasone; Intramuscular; New Israeli Shekel; Per os

Indexed keywords

ADRENALIN; BETAMETHASONE; DEXAMETHASONE;

ARTICLE; BREATHING RATE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROUP; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HEART RATE; HOSPITAL ADMISSION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; OUTPATIENT CARE; PULSE OXIMETRY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TERTIARY HEALTH CARE;

ADMINISTRATION, ORAL; BETAMETHASONE; CHILD; CHILD, PRESCHOOL; CROUP; DEXAMETHASONE; EMERGENCY TREATMENT; FEMALE; GLUCOCORTICOIDS; HUMANS; INFANT; INJECTIONS, INTRAMUSCULAR; MALE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 33747485240     PISSN: 07495161     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pec.0000230552.63799.32     Document Type: Article

References (20)

1. Cruz MN, Stewart G, Rosenberg N. Use of dexamethasone in the outpatient management of acute laryngotracheitis. Pediatrics. 1995;96:220-223.
2. Johnson DW, Jacobson S, Edney PC, et al. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. N Engl J Med. 1998;339:498-503.
3. Klassen TP, Craid WR, Moher D, et al. Nebulized budesonide and oral dexamethasone for treatment of croup. JAMA. 1998;279:1629-1632.
4. Ausejo M, Saenz A, Ba'Pham, et al. The effectiveness of glucocorticoids in treating croup: meta-analysis. BMJ. 1999;319:595-600.
5. Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman and Gilman's The Pharmacologic Basis of Therapeutics. 10th ed. New York: McGraw Hill; 2001:1649-1677.
6. Geelhoed GC, Turner J, Macdonald WBG. Efficacy of a small single dose of oral dexamethasone for outpatient croup: a double blind placebo controlled clinical trial. BMJ. 1996;313:140-142.
7. Luria JW, Gonzalez-del-Rey JA, DiGiulio GA, et al. Effectiveness of oral or nebulized dexamethasone for children with mild croup. Arch Pediatr Adolesc Med. 2001;155:1340-1345.
8. Donaldson D, Poleski D, Knipple E, et al. Intramuscular versus oral dexamethasone for the treatment of moderate-to-severe croup: a randomized, double-blind trial. Acad Emerg Med. 2003;10(1):16-21.
9. Bjornson CL, Klassen TP, Williamson J, et al. A randomized trial of a single dose of oral dexamethasone for mild croup. N Engl J Med. 2004;351:1306-1313.
10. Çetinkaya F, Tüfekçi BS, Kutluk G. A comparison of nebulized budesonide, and intramuscular, and oral dexamethasone for treatment of croup. Int J Pediatr Otorhinolaryngol. 2004;68(4):453-456.
11. Cates C. Taste of oral steroids may be a problem. Available at: http://www.update-software.com/ccng/ccng.exe? Accessed May 2, 2004.
12. Westley CR, Cotton EK, Brook JG. Nebulized racemic epinephrine by IPPB for the treatment of croup: a double-blind study. Am J Dis Child. 1978;132:484-487.
13. Waisman Y, Klein BL, Boenning DA, et al. Prospective randomized double-blind study comparing L-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup). Pediatrics. 1992;89:302-306.
14. Kelley PB, Simon JE. Racemic epinephrine use in croup and disposition. Am J Emerg Med. 1992;10:181-183.
15. Prendergast M, Jones JS, Hartman D. Racemic epinephrine in the treatment of laryngotracheitis: can we identify children for outpatient therapy? Am J Emerg Med. 1994;12:613-616.
16. Rittichier KK, Ledwith CA. Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing. Pediatrics. 2000;106(6):1344-1348.
17. Russell K, Wiebe N, Saenz A, et al. Glucocorticoids for croup. Cochrane Database Syst Rev 2004, Issue 1, Art. No.: CD001955.pub2. Available at: DOI: 10.1002/14651858.CD001955.pub2. Accessed August 1, 2005.
18. Israel Ministry of Health, Pharmacology Division. Available at: http://www.health.gov.il. Accessed August 3, 2005.
19. Hendeles L. Selecting a systemic corticosteroid for acute asthma in young children. J Pediatr. 2003;142:S40-S44.
20. General Workers' Health Fund. Hospital medication price list, 2005.