Thymidylate synthase gene promoter polymorphism in advanced head and neck cancer treated by radio-and 5-fluorouracil chemotherapy;A timidilátszintáz gén promoterpolimorfizmusá nak vizsgálata kis dózisú 5-fluorouracil kemoterápiával és sugárterápiával kezelt elorehaladott stádiumú fej-nyaki rákos betegeken

Magyar Onkologia

Volumn 50, Issue 1, 2006, Pages 33-37

  Kiss László, Zsuzsanna ^a   Nagy, Beatrix ^a   Thurzó, László ^a   Szabó, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; THYMIDYLATE SYNTHASE;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CHI SQUARE DISTRIBUTION; ENZYMOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETICS; HEAD AND NECK TUMOR; HUMAN; MALE; METABOLISM; MIDDLE AGED; PREDICTION AND FORECASTING; PROMOTER REGION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CHI-SQUARE DISTRIBUTION; FEMALE; FLUOROURACIL; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS (GENETICS); RADIOTHERAPY, ADJUVANT; THYMIDYLATE SYNTHASE; TREATMENT OUTCOME;

EID: 33747421050     PISSN: 00250244     EISSN: 20600399     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Aldelstein DJ, Li Y, Adams GL, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92-98, 2003
2. Aschele C, Lonardi S, and Monfardini S, et al. Thymidylate synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. Cancer Treat Rev 1:27-47, 2002
3. Bachaud JM, Cohen-Jonathan E, Alzieu C, et al. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: Final report of a randomized trial. Int Radiat Oncol Biol Phys 36:999-1004, 1996
4. Cadman E, Heimer R, Benz C, et al. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. J Biol Chem 256:1695-1704, 1981
5. Calais G, Alfonsi M, Bardet E, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 91:2081-2086, 1999
6. Etienne MC, Chazal M, Laurent-Puig P, et al. Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil based chemotherapy: Phenotypic and genotypic analysis. J Clin Oncol 20:2832-2843, 2002
7. Krajinovic M, Costea I, Chiasson S, et al. Polymorphism of the thymidilate synthase gene and outcome of acute lymphoblastic leukaemia. Lancet 359:1033-1034, 2002
8. Kawakami K, Omura K, Kanehira E, et al. Polymorphic tandem repeats in the thymidilate synthase gene is associated with its protein expression in human gastrointestinal cancer. Anticancer Res 19:3249-3252, 1999
9. Case II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer 93:1117-1121, 2005
10. Machtay M, Rosenthal DI, Hershock D, et al. Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma: A University of Pennsylvania Phase II Trial. J Clin Oncol 20:3964-3971, 2002
11. McLeod HL, Marsh S, McKay JA, et al. TS pharmacogenetics in colorectal cancer. Proc Am Soc Clin Oncol 20:129a, 2001
12. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16:1215, 1988
13. Nagy B, Mucsi I, Molnár J, et al. Combined effect of cisplatin and 5-fluorouracil with irradiation on tumor cells in vitro. Anticancer Res 22:135-138, 2002
14. Nagy B, Tiszlavicz L, Eller J, et al. Ki-67, cyclin D1, p53 and bcl-2 expression in advanced head and neck cancer. In Vivo 17:93-96, 2003
15. Rustum YM, Harstrick A, Chao S, et al. Thymidilate synthetase inhibitors in cancer therapy. J Clin Oncol 15:389-400, 1997
16. Theil H. Statistical decomposition analysis. Amsterdam: North Holland. 1972
17. Vokes EE, Haraf DJ, Mick R, et al. Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognosis head and neck cancer. J Clin Oncol 11:2351-2359, 1994