Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae

Phytotherapy Research

Volumn 20, Issue 8, 2006, Pages 711-713

  Ahn, M J ^a   Yoon, K D ^b   Kim, C Y ^b   Kim, J H ^c   Shin, C G ^d   Kim, J ^b  

^a Gyeongsang National University   (South Korea)

^b Seoul National University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Chung Ang University   (South Korea)

Author keywords

Diphlorethohydroxycarmalol; Diphlorethohydroxycarmalol nonaacetate; HIV 1 reverse transcriptase; Integrase; Ishige okamurae; Protease

Indexed keywords

CARMALOL DERIVATIVE; DIPHLORETHOHYDROXYCARMALOL; INTEGRASE; ISHIGE OKAMURAE EXTRACT; PLANT EXTRACT; PROTEINASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; BROWN ALGA; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; ISHIGE OKAMURAE; MEDICINAL PLANT; NONHUMAN;

ALGAE, BROWN; ANTI-HIV AGENTS; HETEROCYCLIC COMPOUNDS, 3-RING; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1 REVERSE TRANSCRIPTASE; PLANT EXTRACTS; PROTEASE INHIBITORS; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1; ISHIGE OKAMURAE; PHAEOPHYCEAE;

EID: 33747283162     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1939     Document Type: Article

References (12)

1. Ahn MJ, Yoon KD, Kim CY et al. 2002. Inhibition of HIV-1 reverse transcriptase and HIV-1 integrase and antiviral activity of Korean seaweed extracts. J Appl Phycol 14: 325-329.
2. Ahn MJ, Yoon KD, Min SY et al. 2004. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga, Ecklonia cava. Biol Pharm Bull 27: 544-547.
3. Akihisa T, Kojima S, Yokotaa T, Tamura T. 1991. 24-Methylene-25- methylcholesterol and both C-24 epimers of 24-ethyl-22-dehydrocholesterol in a freshwater green alga Hydrodictyon reticulatum. Phytochemistry 30: 3621-3624.
4. Andrake MD, Skalka AM. 1996. Retroviral integrase, putting the pieces together. J Biol Chem 6: 19633-19636.
5. De Clercq E. 1992. HIV inhibitors targeted at the reverse transcriptase. AIDS Res Hum Retrov 8: 119-131.
6. Jin HJ, Kim JH, Sohn CH et al. 1997. Inhibition of Taq DNA polymerase by seaweed extracts from British Columbia, Canada and Korea. J Appl Phycol 9: 383-388.
7. Kempf DJ, Codacovi L, Wang XC et al. 1993. Symmetry-based inhibitors of HIV professe. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3- hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol. J Med Chem 36: 320-330.
8. Kim JH, Hudson JB, Huang AM et al. 1997. Biological activities of seaweed extracts from British Columbia, Canada, and Korea. I. Antiviral activity. Can J Bot 75: 1656-1660.
9. Li SM, Glombitza KW. 1991. Carmalols and phlorethofuhalols from the brown alga Carpophyllum maschalocarpum. Phytochemistry 30: 3417-3421.
10. Pommier Y, Pilon AA, Bajaj K, Mazumder A, Neamati N. 1997. HIV-1 integrase as a target for antiviral drugs. Antiviral Chem Chemother 8: 463-483.
11. Rey MA, Spire B, Dormont D et al. 1984. Characterization of the RNA dependent DNA polymerase of a new human T lymphotropic retrovirus (lymphadenopathy associated virus). Biochem Biophys Res Commun 121: 126-133.
12. Tourne K, Miyata M, Egawa K et al. 2004. Isolation of diphlorethohydroxycarmalol from a brown alga Ishige okamurae. Natural Medicines 58: 79-80.