Numerical simulation of microcarrier motion in a rotating wall vessel bioreactor

Biomedical and Environmental Sciences

Volumn 19, Issue 3, 2006, Pages 163-168

  Ju, Zhi Hao ^a   Liu, Tian Qing ^a   Ma, Xue Hu ^a   Cui, Zhan Feng ^a,b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bioreactor; Numerical simulation; Rotating wall vessel; Tissue engineering

Indexed keywords

MICROSPHERE;

ARTICLE; BIOREACTOR; COMPUTER SIMULATION; FLOW KINETICS; MECHANICAL STRESS; METHODOLOGY; MOTION; POROSITY; ROTATION; TISSUE ENGINEERING;

BIOREACTORS; COMPUTER SIMULATION; MICROSPHERES; MOTION; POROSITY; RHEOLOGY; ROTATION; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 33747216878     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Godbey W T, Atala A (2002). In vitro systems for tissue engineering. Ann N Y Acad Sci 961, 10-26.
2. http://microgravity.msfc.nasa.gov
3. Granet C, Laroche N, Vico L, et al. (1998). Rotating-wall vessels, promising bioreactors for osteoblastic cell culture: comparison with other 3D conditions, Mecical & Biologltical Engineering & Computing 36(4), 513-519.
4. Mitteregger R, Vogt G, Rossmanith E, et al. (1999). Rotary cell culture system (RCCS): A new method for cultivating hepatocytes on microcarriers. International Artificial Organs 22(12), 816-822.
5. Santos B D, Shiragami N, Unno H, et al. (1994). A model for microcarrier motion inside a horizontally rotating bioreactor for animal cell culture. Bioprocess Engineering 11(3), 115-120
6. Tsao Y M D, Boyd E, Spaulding G (1994). Fluid dynamics within a rotating bioreactor in space and earth environments. Spacecraft and Rockets 31(6), 937-943
7. Gao H X (2000). Numerical Studies of Microcarrier Particle Dynamics and Associated Mass Transfer in Rotating-Wall Vessels, PhD Dissertation, University of Pennsylvania, 2000.
8. Qiu Q Q, Ducheyne P, Ayyaswamy P S (1999). Fabrication, characterization and evaluation of bioceramic hollow microspheres used as microcarriers for 3-D bone tissue formation in rotating bioreactors. Biomaterials 20, 989-1001.
9. Begley C M, Kleis S J (2000). The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor. Biotech and Bioengineering 70(1), 32-40.
10. Freed L E, Vunjak-Novakovic G (1995). Cultivation of cell-polymer tissue constructs in simulated microgravity. Biotech and Bioengineering 46, 306-313.
11. Pollack S R, Meaney D F, Levine E M, et al. (2000). Numerical Model and Experimental Validation of Microcarrier Motion in a Rotating Bioreator. Tissue Engineering 6(5), 519-530.
12. Milne-Thomson L M (1996). Theoretical hydrodynamics, New York: Dover Publications.
13. Hammond T G, Hammond J M (2001). Optimized suspension culture: the rotating-wall vessel. American J Physiology-renal Physiology 281(1), F12-F25.
14. Xue L Y (2002). The measurement trajectory of microcarrier particles in rotating wall vessel bioreactor, Bachelor Thesis, Dalian University of Technology.
15. Bird R B, Stewart W E, Lightfoot E N (2002). Transport Phenomena. 2nd ed., New York, John Wiley & Sons, Inc.
16. Sanford G L, Ellerson D, Melhado-Gardner C, et al. (2002). Three-dimensional growth of endothelial cells in the microgravity based rotating wall vessel bioreactor. In Vitro Cellular & Developmental Biology-Animal. 38(9), 493-504.