The diabetogenic antibiotic streptozotocin modifies the tryptic digest pattern for peptides of the enzyme O-GlcNAc-selective N-acetyl-β-d-glucosaminidase that contain amino acid residues essential for enzymatic activity

Biochemical Pharmacology

Volumn 72, Issue 6, 2006, Pages 710-718

  Lee, Thomas N ^a   Alborn, William E ^a   Knierman, Michael D ^a   Konrad, Robert J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Cells; Islets; O GlcNAcase; OGT; Streptozotocin

Indexed keywords

AMINO ACID; ANTIBIOTIC AGENT; ASPARATYLISOLEUCYLTHREONYLPHENYLALANYLSERYLASPARAGINYLPROLYLLYSINE; CYSTEINE; GLUTAMIC ACID; GLUTAMYLTYROSYLGLUTAMYLISOLEUCYLGLUTAMYLPHENYLALANYLISOLEUCYLTYROSYL ISOLEUCYLALANYLSERYLPROLYLGLYCYLLEUCYLASPARTYLISOLEUCYLTHREONYLPHENYLALANYL SERYLASPARAGINYLPROLYLLYSINE; GLYCINE; LEUCYLGLYCYLCYSTEINYLPHENYLALANYLGLUTAMYLISOLEUCYLALANYLLYSINE; LYSYLLEUCYLASPARTYLGLUTAMINYLVALYLSERYLGLUTAMINYLPHENYLALANYLGLYCYL CYSTEINYLARGININE; N ACETYL BETA GLUCOSAMINIDASE; N ACETYLGLUCOSAMINE; PEPTIDE; PHENYLALANINE; STREPTOZOCIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; COVALENT BOND; DIABETOGENESIS; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME SPECIFICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; MUTAGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

ACETYLGLUCOSAMINIDASE; AMINO ACID SEQUENCE; ANIMALS; BETA-N-ACETYLHEXOSAMINIDASE; DIABETES MELLITUS, EXPERIMENTAL; HISTONE ACETYLTRANSFERASES; HUMANS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; STREPTOZOCIN; SUBSTRATE SPECIFICITY;

EID: 33747179908     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.005     Document Type: Article

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