Molecular modelling of KATP channel blockers-ADP/ATP carrier interactions

IEE Proceedings: Systems Biology

Volumn 153, Issue 5, 2006, Pages 390-393

  Ziemys, A ^a   Toleikis, A ^b   Kopustinskiene, D M ^b  

^a VYTAUTAS MAGNUS UNIVERSITY   (Lithuania)

^b KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; MATHEMATICAL MODELS; MATRIX ALGEBRA; MOLECULES;

CHANNEL BLOCKERS; MITOCHONDRIAL CARRIER; MOLECULAR MODELLING; MOLECULE-MOLECULE INTERACTIONS;

MOLECULAR BIOLOGY;

5 HYDROXYDECANOIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CARRIER PROTEIN; GLIBENCLAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; PROTON; TOLBUTAMIDE;

ARTICLE; BINDING SITE; BIOCHEMISTRY; CATION TRANSPORT; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; HYPOTHESIS; MITOCHONDRION; MOLECULAR INTERACTION; MOLECULAR MODEL; POTASSIUM TRANSPORT; PREDICTION; PROTEIN TRANSPORT; PROTON TRANSPORT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, PROTEIN;

EID: 33747159120     PISSN: 17412471     EISSN: None     Source Type: Journal    
DOI: 10.1049/ip-syb:20060007     Document Type: Article

References (15)

1. Garlid, K.D., Dos Santos, P., Xie, Z.J., Costa, A.D., and Paucek, P.: 'Mitochondrial potassium transport: The role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection', Biochim. Biophys. Acta, 2003, 1606, (1-3), p. 1-21
2. O'Rourke, B.: 'Evidence for mitochondrial K+ channels and their role in cardioprotection', Circ. Res., 2004, 94, (4), p. 420-432 0009-7330
3. Kane, G.C., Liu, X.K., Yamada, S., Olson, T.M., and Terzic, A.: 'Cardiac KATP channels in health and disease', J. Mol. Cell Cardiol., 2005, 38, (6), p. 937-943
4. Hanley, P.J., and Daut, J.: 'K(AAP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms', J. Mol. Cell Cardiol., 2005, 39, (1), p. 17-50
5. Ardehali, H., Chen, Z., Ko, Y., Mejia-Alvarez, R., and Marban, E.: 'Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity', Proc. Natl. Acad. Sci. USA, 2004, 101, (32), p. 11880-11885 0027-8424
6. Pebay-Peyroula, E., Dahout-Gonzalez, C., Kahn, R., Trezeguet, V., Lauquin, G.J., and Brandolin, G.: 'Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside', Nature, 2003, 426, (6962), p. 39-44 10.1038/nature02056 0028-0836
7. Kopustinskiene, D.M., Toleikis, A., and Saris, N.E.: 'Adenine nucleotide translocase mediates the K(ATP)-channel-openers-induced proton and potassium flux to the mitochondrial matrix', J. Bioenerg. Biomembr., 2003, 35, (2), p. 141-148 10.1023/A:1023746103401 0145-479X
8. Frisch, M.J., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Zakrzewski, V.G., Montgomery, J.A., Stratmann, R.E., Burant, J.C., Dapprich, S., Millam, J.M., Daniels, A.D., Kudin, K.N., Strain, M.C., Farkas, O., Tomasi, J., Barone, V., Cossi, M., Cammi, R., Mennucci, B., Pomelli, C., Adamo, C., Clifford, S., Ochterski, J., Petersson, G.A., Ayala, P.Y., Cui, Q., Morokuma, K., Malick, D.K., Rabuck, A.D., Raghavachari, K., Foresman, J.B., Cioslowski, J., Ortiz, J.V., Baboul, A.G., Stefanov, B.B., Liu, G., Liashenko, A., Piskorz, P., Komaromi, I., Gomperts, R., Martin, R.L., Fox, D.J., Keith, T., Al-Laham, M.A., Peng, C.Y., Nanayakkara, A., Challacombe, M., Gill, P.M.W., Johnson, B., Chen, W., Wong, M.W., Andres, J.L., Gonzalez, C., Head-Gordon, M., Replogle, E.S., and Pople, J.A.: 'Gaussian 98', (Gaussian, Inc., Pittsburgh, PA, USA 1998), Revision A.9
9. Goodsell, D.S., and Olson, A.J.: 'Automated docking of substrates to proteins by simulated annealing', Proteins, 1990, 8, (3), p. 195-202
10. Mehler, E.L., and Solmajer, T.: 'Electrostatic effects in proteins: comparison of dielectric and charge models', Protein Eng., 1991, 4, (8), p. 903-910
11. Brustovetsky, T., Shalbuyeva, N., and Brustovetsky, N.: 'Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria', J. Physiol., 2005, 568, (Pt. 1), p. 47-59
12. Hanley, P.J., Drose, S., Brandt, U., Lareau, R.A., Banerjee, A.L., Srivastava, D.K., Banaszak, L.J., Barycki, J.J., Van Veldhoven, P.P., and Daut, J.: '5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids', J. Physiol., 2005, 562, (Pt. 2), p. 307-318
13. Pebay-Peyroula, E., and Brandolin, G.: 'Nucleotide exchange in mitochondria: Insight at a molecular level', Curr. Opin. Struct. Biol., 2004, 14, (4), p. 420-425
14. Panov, A., Filippova, S., and Lyakhovich, V.: 'Adenine nucleotide translocase as a site of regulation by ADP of the rat liver mitochondria permeability to H+ and K+ ions', Arch. Biochem. Biophys., 1980, 199, (2), p. 420-426
15. Halestrap, A.P.: 'The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism', Biochim. Biophys. Acta, 1989, 973, (3), p. 355-382