Influence of ambient moisture on the compaction behavior of microcrystalline cellulose powder undergoing uni-axial compression and roller-compaction: A comparative study using near-infrared spectroscopy

Journal of Pharmaceutical Sciences

Volumn 94, Issue 10, 2005, Pages 2301-2313

  Gupta, Abhay ^a,c   Peck, Garnet E ^a   Miller, Ronald W ^b   Morris, Kenneth R ^a  

^a PURDUE UNIVERSITY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Compact strength; Compaction; Dry granulation; Granulation; Heckel analysis; Microcrystalline cellulose; Milling; Multivariate analysis; Near infrared spectroscopy; Particle size; PAT; Roller compaction; Three point beam bending method

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

AMBIENT AIR; ARTICLE; COMPARATIVE STUDY; DRY POWDER; MOISTURE; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY; PARTICLE SIZE; POROSITY; PREDICTION; RECEPTOR DENSITY; SIMULATION; TENSILE STRENGTH; THICKNESS; YOUNG MODULUS;

EID: 23844524626     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20430     Document Type: Article

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