Distal tubule acidification

Journal of Nephrology

Volumn 19, Issue SUPPL. 9, 2006, Pages

  Geibel, John P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acid secretion; Intercalated cells; Kidney; Nephron; pH

Indexed keywords

CARRIER PROTEIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM PROTON EXCHANGE PROTEIN;

ACID BASE BALANCE; ACID SECRETION; CELL COUNT; CELL TYPE; CELLULAR DISTRIBUTION; ELECTROLYTE DISTURBANCE; ENZYME ACTIVITY; ENZYME REGULATION; HORMONAL REGULATION; HUMAN; KIDNEY ACIDIFYING CAPACITY; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; METABOLIC DISORDER; NEPHRON; NONHUMAN; PH; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; ANIMAL; CYTOLOGY; ION TRANSPORT; METABOLISM; PHYSIOLOGY;

ANIMALS; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; KIDNEY TUBULES, DISTAL; PROTON-TRANSLOCATING ATPASES;

EID: 33747135443     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. 3 flux by VIP, isoproterenol, angiotensin II, and ADH. Am J Physiol 1994; 266: F878-83.
2. Marin-Grez M, Valles P, Odigie PI. Involvement of renal kallikrein in the regulation of bicarbonate excretion in rats. J Physiol 1995; 488: 163-70.
3. Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. The amino-terminal domain of the E subunit of vacuolar H (+) -ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem 2002; 277: 38409-15.
4. Levine DZ, Iacovitti M, Harrison V. Bicarbonate secretion in vivo by rat distal tubules during alkalosis induced by dietary chloride restriction and alkali loading. J Clin Invest 1991; 87: 1513-8.
5. Bowman EJ, Siebers A, Altendorf K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci USA 1988; 85: 7972-6.
6. Brown D, Breton S. Mitochondria-rich, proton-secreting epithelial cells. J Exp Biol 1996; 199: 2345-58.
7. Karet FE, Gainza FJ, Gyory AZ, Unwin RJ, Wrong O, Tanner MJ, Nayir A, Alpay H, Santos F, Hulton SA, Bakkaloglu A, Ozen S, Cunningham MJ, di Pietro A, Walker WG, Lifton RP. Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc Natl Acad Sci USA 1998; 95: 6337-42.
8. Stone DK, Seldin DW, Kokko JP, Jacobson HR. Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect. J Clin Invest 1983; 72: 77-83.
9. Banerjee A, Shih T, Alexander EA, Schwartz JH. SNARE proteins regulate H(+)-ATPase redistribution to the apical membrane in rat renal inner medullary collecting duct cells. J Biol Chem 1999; 274: 26518-22.
10. Brosius FC III, Alper SL, Garcia AM, Lodish HF. The major kidney band 3 gene transcript predicts an amino-terminal truncated band 3 polypeptide. J Biol Chem 1989; 264: 7784-7.
11. Brown D, Hirsch S, Gluck S. An H+-ATPase in opposite plasma membrane domains in kidney epithelial cell subpopulations. Nature 1988; 331: 622-4.
12. Chen YA, Scheller RH. SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol 2001; 2: 98-106.
13. Allen AM, Zhuo J, Mendelsohn FA. Localization and function of angiotensin AT1 receptors. Am J Hypertens 2000; 13 (suppl): S31-8.
14. Sabolic I, Katsura T, Verbavatz JM, Brown D. The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Membr Biol 1995; 143: 165-75.
15. Sollner T, Whiteheart SW, Brunner M, Erdjument-Bromage H, Geromanos S, Tempst P, Rothman JE. SNAP receptors implicated in vesicle targeting and fusion. Nature 1993; 362: 318-24.
16. Gunther W, Piwon N, Jentsch TJ. The CIC-5 chloride channel knock-out mouse - an animal model for Dent's disease. Pflugers Arch 2003; 445: 456-62.
17. Waldegger S, Jentsch TJ. From Loons to tonicity: physiology of CLC chloride channels. J Am Soc Nephrol 2000; 11: 1331-9.
18. Mohammad-Panah R, Ackerley C, Rommens J, Choudhury M, Wang Y, Bear CE. The chloride channel ClC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia. J Biol Chem 2002; 277: 566-74.
19. Verlander JW, Moudy RM, Campbell WG, Cain BD, Wingo CS. Immunohistochemical localization of H-K-ATPase alpha (2c) -subunit in rabbit kidney. Am J Physiol Renal Physiol 2001; 281: F357-65.
20. Verrey F. Early aldosterone action: toward filling the gap between transcription and transport. Am J Physiol 1999; 277: F319-27.
21. Hirata T, Nakamura N, Omote H, Wada Y, Futai M. Regulation and reversibility of vacuolar H (+)-ATPase. J Biol Chem 2000; 275: 386-9.
22. Dubose TD Jr. Molecular and pathophysiologic mechanisms of hyperkalemic metabolic acidosis. Trans Am Clin Climatol Assoc 2000; 111: 122-33.
23. Hamm LL, Simon EE. Roles and mechanisms of urinary buffer excretion. Am J Physiol 1987; 253: F595-605.
24. Lencer WI, Verkman AS, Arnaout MA, Ausiello DA, Brown D. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. J Cell Biol 1990; 111: 379-89.
25. Leng XH, Manolson MF, Liu Q, Forgac M. Site-directed mutagenesis of the 100-kDa subunit (Vphlp) of the yeast vacuolar (H+)-ATPase. J Biol Chem 1996; 271: 22487-93.
26. Madsen KM, Tisher CC. Cellular response to acute respiratory acidosis in rat medullary collecting duct. Am J Physiol 1983; 245: F670-9.
27. Perez L, Carrasco L. Involvement of the vacuolar H(+)-ATPase in animal virus entry. J Gen Virol 1994; 75 (Pt 10): 2595-606.
28. Valles P, Ebner S, Manucha W, Gutierrez L, Marin-Grez M. Effect of glandular kallikrein on distal nephron. Am J Physiol 1997; 273: F807-16.
29. Valles PG, Manucha WA. H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II. Kidney Int 2000; 58: 1641-51.
30. Erramouspe J, Galvez R, Fischel DR. Newborn renal tubular acidosis associated with prenatal maternal toluene sniffing. J Psychoactive Drugs 1996; 28: 201-4.
31. Wang ZQ, Gluck S. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. J Biol Chem 1990; 265: 21957-65.
32. Wang T, Egbert AL Jr, Abbiati T, Aronson PS, Giebisch G. Mechanisms of stimulation of proximal tubule chloride transport by formate and oxalate. Am J Physiol 1996; 271: F446-50.
33. Gekle M, Mildenberger S, Freudinger R, Silbernagl S. Long-term protein exposure reduces albumin binding and uptake in proximal tubule-derived opossum kidney cells. J Am Soc Nephrol 1998; 9: 960-8.
34. Bruce LJ, Wrong O, Toye AM, Young MT, Ogle G, Ismail Z, Sinha AK, McMaster P, Hwaihwanje I, Nash GB, Hart S, Lavu E, Palmer R, Othman A, Unwin RJ, Tanner MJ. Band 3 mutations, renal tubular acidosis and South-East Asian oval-ocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells. Biochem J 2000; 350: 41-51.
35. Farman N, Oblin ME, Lombes M, Delahaye F, Westphal HM, Bonvalet JP, Gasc JM. Immunolocalization of gluco- and mineralocorticoid receptors in rabbit kidney. Am J Physiol 1991; 260: C226-33.
36. Gekle M, Mildenberger S, Freudinger R, Silbernagl S. Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cells. Am J Physiol 1995; 268: F899-906.
37. Kim YH, Kwon TH, Frische S, Kim J, Tisher CC, Madsen KM, Nielsen S. Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol 2002; 283: F744-54.
38. Kornandakieti C, Tannen RL. H+ transport by the aldosterone-deficient rat distal nephron. Kidney Int 1984; 25: 629-35.
39. Morales MM, Carroll TP, Morita T, Schwiebert EM, Devuyst O, Wilson PD, Lopes AG, Stanton BA, Dietz HC, Cutting GR, Guggino WB. Both the wild type and a functional isoform of CFTR are expressed in kidney. Am J Physiol 1996; 270: F1038-48.
40. Moriyama Y, Nelson N. H+-translocating ATPase in Golgi apparatus. Characterization as vacuolar H+-ATPase and its subunit structures. J Biol Chem 1989; 264: 18445-50.
41. Vitavska O, Wieczorek H, Merzendorfer H. A novel role for subunit C in mediating binding of the H+-V-ATPase to the actin cytoskeleton. J Biol Chem 2003; 278: 18499-505.
42. Arata Y, Nishi T, Kawasaki-Nishi S, Shao E, Wilkens S, Forgac M. Structure, subunit function and regulation of the coated vesicle and yeast vacuolar (H(+))-ATPases. Biochim Biophys Acta 2002; 1555: 71-4.
43. Donckerwolcke RA, Van Biervliet JP, Koorevaar G, Kuijten RH, van Stekelenburg GJ. The syndrome of renal tubular acidosis with nerve deafness. Acta Paediatr Scand 1976; 65: 100-4.
44. Geibel J, Giebisch G, Boron WF. Angiotensin II stimulates both Na(+)-H+ exchange and Na+/. Proc Natl Acad Sci USA 1990; 87: 7917-20.
45. Goyal S, Vanden HG, Aronson PS. Renal expression of novel Na+/H+ exchanger isoform NHE8. Am J Physiol Renal Physiol 2003; 284: F467-73.
46. Lu M, Sautin YY, Holliday LS, Gluck SL. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem 2004; 279: 8732-9.
47. Kawasaki-Nishi S, Nishi T, Forgac M. Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation. J Biol Chem 2001; 276: 17941-8.
48. Al-Awqati Q. Effect of aldosterone on the coupling between H+ transport and glucose oxidation. J Clin Invest 1977; 60: 1240-7.
49. Breton S, Smith PJ, Lui B, Brown D. Acidification of the male reproductive tract by a proton pumping (H+)-ATPase. Nat Med 1996; 2: 470-2.
50. Breton S, Tyszkowski R, Sabolic I, Brown D. Postnatal development of H+ATPase (proton-pump)-rich cells in rat epididymis. Histochem Cell Biol 1999; 111: 97-105.
51. Reenstra WW, Sabolic I, Bae HR, Verkman AS. Protein kinase A dependent membrane protein phosphorylation and chloride conductance in endosomal vesicles from kidney cortex. Biochemistry 1992; 31: 175-81.
52. Sabolic I, Herak-Kramberger CM, Brown D. Subchronic cadmium treatment affects the abundance and arrangement of cytoskeletal proteins in rat renal proximal tubule cells. Toxicology 2001; 165: 205-16.
53. Taher SM, Anderson RJ, McCartney R, Popovtzer MM, Schrier RW. Renal tubular acidosis associated with toluene "sniffing". N Engl J Med 1974; 290: 765-8.
54. Lou X, McQuistan T, Orlando RA, Farquhar MG. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J Am Soc Nephrol 2002; 13: 918-27.
55. Smardon AM, Tarsio M, Kane PM. The RAVE complex is essential for stable assembly of the yeast V-ATPase. J Biol Chem 2002; 277: 13831-9.
56. Schwartz GJ, Al-Awqati Q. Regulation of transepithelial H+ transport by exocytosis and endocytosis. Annu Rev Physiol 1986; 48: 153-61.
57. Al-Awqati Q. Plasticity in epithelial polarity of renal intercalated cells: targeting of the H(+)-ATPase and band 3. Am J Physiol 1996; 270: C1571-80.
58. Stockand JD. New ideas about aldosterone signaling in epithelia. Am J Physiol Renal Physiol 2002; 282: F559-76.
59. Sabolic I, Ljubojevic M, Herak-Kramberger CM, Brown D. Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules. Am J Physiol Renal Physiol 2002; 283: F1389-402.
60. Yenchitsomanus PT, Vasuvattakul S, Kirdpon S, Wasanawatana S, Susaengrat W, Sreethiphayawan S, Chuawatana D, Mingkum S, Sawasdee N, Thuwajit P, Wilairat P, Malasit P, Nimmannit S. Autosomal recessive distal renal tubular acidosis caused by G701D mutation of anion exchanger 1 gene. Am J Kidney Dis 2002, 40: 21-9.
61. Elkjaer ML, Birn H, Agre P, Christensen EI, Nielsen S. Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells. Eur J Cell Biol 1995; 67: 57-72.
62. Thorens B, Roth J. Intracellular targeting of GLUT4 in transfected insulinoma cells: evidence for association with constitutively recycling vesicles distinct from synaptophysin and insulin vesicles. J Cell Sci 1996; 109: 1311-23.
63. Kettner C, Bertl A, Obermeyer G, Slayman C, Bihler H. Electrophysiological analysis of the yeast V-type proton pump: variable coupling ratio and proton shunt. Biophys J 2003; 85: 3730-8.
64. Quentin F, Eladari D, Cheval L, Lopez C, Goossens D, Colin Y, Cartron JP, Paillard M, Chambrey R. RhBG and RhCG, the putative ammonia transporters, are expressed in the same cells in the distal nephron. J Am Soc Nephrol 2003; 14: 545-54.
65. Vio CP, Olavarria V, Gonzalez C, Nazal L, Cordova M, Balestrini C. Cellular and functional aspects of the renal kallikrein system in health and disease. Biol Res 1998; 31: 305-22.
66. Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int 1997; 51: 125-37.
67. Van Hille B, Vanek M, Richener H, Green JR, Bilbe G. Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase. Biochem Biophys Res Commun 1993; 197: 15-21.
68. Herak-Kramberger CM, Sabolic I, Blanusa M, Smith PJ, Brown D, Breton S. Cadmium inhibits vacuolar H(+) ATPase-mediated acidification in the rat epididymis. Biol Reprod 2000; 63: 599-606.
69. Muller O, Neumann H, Bayer MJ, Mayer A. Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 2003; 116: 1107-15.
70. Karet FE, Finberg KE, Nelson RD, Nayir A, Mocan H, Sanjad SA, Rodriguez-Soriano J, Santos F, Cremers CW, Di Pietro A, Hoffbrand BI, Winiarski J, Bakkaloglu A, Ozen S, Dusunsel R, Goodyer P, Hulton SA, Wu DK, Skvorak AB, Morton CC, Cunningham MJ, Jha V, Lifton RP. Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet 1999; 21: 84-90.
71. Roscoe JM, Goldstein MR, Halperin ML, Schloeder FX, Stinebaugh RJ. Effect of amphotercin B on urine acidification in rats: implications for the pathogenesis of distal renal tubular acidosis. J Lab Clin Med 1977; 89: 463-70.
72. Arruda JA, Kurtzman NA. Mechanisms and classification of deranged distal urinary acidification. Am J Physiol 1980; 239: F515-23.
73. Heitman J, Agre P. A new face of the Rhesus antigen. Nat Genet 2000; 26: 258-9.
74. Emmons C. Transport characteristics of the apical anion exchanger of rabbit cortical collecting duct beta-cells. Am J Physiol 1999; 276: F635-43.
75. McKinney TD, Burg MB. Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro. J Clin Invest 1977; 60: 766-8.
76. Brown D, Sabolic I, Gluck S. Colchicine-induced redistribution of proton pumps in kidney epithelial cells. Kidney Int Suppl 1991; 33: S79-83.
77. Dowland LK, Luyckx VA, Erick AH, Leclercq B, Yu AS. Molecular cloning and characterization of an intracellular chloride channel in the proximal tubule cell line, LLC-PK1. J Biol Chem 2000; 275: 37765-73.
78. Smith AN, Skaug J, Choate KA, Nayir A, Bakkaloglu A, Ozen S, Hulton SA, Sanjad SA, Al-Sabban EA, Lifton RP, Scherer SW, Karet FE. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nat Genet 2000; 26: 71-5.
79. Bae HR, Verkman AS. Protein kinase A regulates chloride conductance in endocytic vesicles from proximal tubule. Nature 1990; 348: 637-9.
80. Umemoto N, Yoshihisa T, Hirata R, Anraku Y. Roles of the VMA3 gene product, subunit c of the vacuolar membrane H(+)-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of Saccharomyces cerevisiae. J Biol Chem 1990; 265: 18447-53.
81. Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiol 1996; 270: C382-8.
82. Lemann J Jr, Adams ND, Wilz DR, Brenes LG. Acid and mineral balances and bone in familial proximal renal tubular acidosis. Kidney Int 2000; 58: 1267-77.
83. van Weert AW, Dunn KW, Gueze HJ, Maxfield FR, Stoorvogel W. Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump. J Cell Biol 1995; 130: 821-34.
84. Harris HW Jr, Zeidel ML, Jo I, Hammond TG. Characterization of purified endosomes containing the antidiuretic hormone-sensitive water channel from rat renal papilla. J Biol Chem 1994; 269: 11993-2000.
85. Laski ME, Kurtzman NA. Site of the acidification defect in the perfused postobstructed collecting tubule. Miner Electrolyte Metab 1989; 15: 195-200.
86. Sumner JP, Dow JA, Earley FG, Klein U, Jager D, Wieczorek H. Regulation of plasma membrane V-ATPase activity by dissociation of peripheral subunits. J Biol Chem 1995; 270: 5649-53.
87. 3 exchangers of rat thick limbs. Am J Physiol 1998; 275: F334-42.
88. Levine DZ, Iacovitti M, Buckman S, Hincke MT, Luck B, Fryer JN. ANG II-dependent. Am J Physiol 1997; 272: F799-808.
89. Levine DZ, Iacovitti M, Luck B, Hincke MT, Burns KD, Fryer JN. Surviving rat distal tubule bicarbonate reabsorption: effects of chronic AT(1) blockade. Am J Physiol Renal Physiol 2000; 278: F476-83.
90. Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE. Pendrin: an apical Cl-/OH-/. Am J Physiol Renal Physiol 2001; 280: F356-64.
91. Van Adelsberg J, Al-Awqati Q. Regulation of cell pH by Ca+2-mediated exocytotic insertion of H+-ATPases. J Cell Biol 1986; 102: 1638-45.
92. 3 exchanger of beta intercalated cells. J Biol Chem 1993; 268: 11283-9.
93. Bailey M, Capasso G, Agulian S, Giebisch G, Unwin R. The relationship between distal tubular proton secretion and dietary potassium depletion: evidence for up-regulation of H+-ATPase. Nephrol Dial Transplant 1999; 14: 1435-40.
94. Bouby N, Hus-Citharel A, Marchetti J, Bankir L, Corvol P, Llorens-Cortes C. Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron. J Am Soc Nephrol 1997; 8: 1658-67.
95. Brown MT, Cunningham MJ, Ingelfinger JR, Becker AN. Progressive sensorineural hearing loss in association with distal renal tubular acidosis. Arch Otolaryngol Head Neck Surg 1993; 119: 458-60.
96. Choi JS, Kim KR, Ahn DW, Park YS. Cadmium inhibits albumin endocytosis in opossum kidney epithelial cells. Toxicol Appl Pharmacol 1999; 161: 146-52.
97. Baum M, Quigley R, Quan A. Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption. Am J Physiol 1997; 273: F595-600.
98. Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci USA 1997; 94: 6752-7.