The role of the glyoxalase pathway in reducing mesothelial toxicity of glucose degradation products

Peritoneal Dialysis International

Volumn 26, Issue 2, 2006, Pages 259-265

  Korybalska, Katarzyna ^a   Wisniewska Elnur, Justyna ^a   Trómińska, Joanna ^a   Jörres, Achim ^b   Brȩborowicz, Andrzej ^a   Witowski, Janusz ^a,b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Biocompatibility; Dialysis fluids; Glucose degradation products; Glutathione; Glyoxalase; Mesothelial cells

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; GLUCOSE DEGRADATION PRODUCT; GLUTATHIONE; INTERLEUKIN 6; LACTOYLGLUTATHIONE LYASE; PERITONEAL DIALYSIS FLUID; GLUCOSE;

ARTICLE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INCUBATION TEMPERATURE; INCUBATION TIME; MESOTHELIUM CELL; PERITONEAL DIALYSIS; PERITONEUM CELL; PRIORITY JOURNAL; CELL CULTURE; EPITHELIUM; EPITHELIUM CELL; METABOLISM;

CELLS, CULTURED; EPITHELIAL CELLS; EPITHELIUM; GLUCOSE; HUMANS; LACTOYLGLUTATHIONE LYASE;

EID: 33747120699     PISSN: 08968608     EISSN: None     Source Type: Journal    
DOI: 10.1177/089686080602600223     Document Type: Article

References (26)

1. Morgan LW, Wieslander A, Davies M, Horiuchi T, Ohta Y, Beavis MJ, et al. Glucose degradation products (GDP) retard remesothelialization independently of d-glucose concentration. Kidney Int 2003; 64:1854-66.
2. Witowski J, Bender TO, Wisniewska-Elnur J, Ksiazek K, Passlick-Deetjen J, Breborowicz A, et al. Mesotheliattoxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, notto glucose per se. Perit Dial Int 2003; 23:381-90.
3. Nilsson-Thorell CB, Muscalu N, Andren AH, Kjellstrand PT, Wieslander AP. Heat sterilization of fluids for peritoneal dialysis gives rise to aldehydes. Perit Dial Int 1993; 13: 208-13.
4. Thornalley PJ. Glyoxalase I - structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans 2003; 31:1343-8.
5. Breborowicz A, Rodela H, Martis L, Oreopoulos DG. Intracellular glutathionein human peritoneal mesothelial cells exposed in vitro to dialysis fluid. Int J Artif Organs 1996; 19:268-75.
6. Nakayama M, Kawaguchi Y, Yamada K, Hasegawa T, Takazoe K, Katoh N, et al. Immunohistochemical detection of advanced glycosylation end-products in the peritoneum and its possible pathophysiological rote in CAPD. Kidney Int 1997; 51:182-6
7. Inagi R, Miyata T, Ueda Y, Yoshino A, Nangaku M. van Ypersele OS, et al. Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid. Kidney Int 2002; 62: 679-87.
8. Stylianou E, Jenner LA, Davies M, Coles GA, Williams JD. Isolation, culture and characterization of human peritoneal mesothelial cells. Kidney Int 1990; 37:1563-70.
9. Witowski J, Korybalska K, Wisniewska J, Breborowicz A, Gahl AM, Frei U, et al. Effect ofglucose degradation products on human peritoneal mesothelial cell function. J Am Soc Nephrol 2000; 11:729-39.
10. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
11. McLellan AC, Thornalley PJ. Glyoxalase activity in human red blood cells fractioned by age. Mech Ageing Dev 1989; 48:63-71.
12. McLellan AC, Thornalley PJ. Sample storage conditions for the assay of glyoxalase activities in whole blood samples. Ann Clin Biochem 1992; 29:222-3.
13. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969; 27:502-22.
14. Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinyl-pyridine. Anal Biochem 1980; 106:207-12.
15. Jorres A, Dinter H, Toptey N, Gahl GM, Frei U, Scholz P. Inhibition of tumour necrosis factor production in endotoxin-stimulated human mononuclear leukocytes by the prostacyclin analogue iloprost: cellular mechanisms. Cytokine 1997; 9:119-25.
16. Ranganathan S, Walsh ES, Godwin AK, Tew KD. Cloning and characterization of human colon glyoxalase-I. J Biol Chem 1993; 268:5661-7.
17. O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, et al. axl, atransforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 1991; 11:5016-31.
18. van Klaveren RJ. Demedts M, Nemery B. Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes. Eur Respir J 1997; 10:1392-400.
19. Jellum E. Metabolism of the ketoaldehyde 2-keto-3-deoxyglucose. Biochim Biophys Acta 1968; 165:357-63.
20. Legge M, Lash GE, Bird SD, Walker RJ. Formaldehyde in heat sterilized peritoneal dialysis solutions: scavenging system for its removal. Perit Dial Int 1998; 18:228-31.
21. Bird SD, Legge M, Walker RJ. Formaldehyde scavenging from peritoneal dialysis solutions using reduced aminothiol compounds. Nephrology (Canton) 2004; 9:65-72.
22. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999; 27:916-21.
23. Breborowicz A, Witowski J, Polubinska A, Pyda M, Oreopoulos D. L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products. Nephrol Dial Transplant 2004; 19:3005-11.
24. Shinohara M, Thornalley PJ, Giardino I, Beisswenger P, Thorpe SR, Onoratod, et al. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest 1998; 101:1142-7.
25. Wefers H, Sies H. Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen. Eur J Biochem 1983; 137:29-36.
26. Saez G, Thornalley PJ, Hill HA, Hems R, Bannister JV. The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes. Biochim Biophys Acta 1982; 719:24-31.