Growth inhibition of Candida species and Aspergillus fumigatus by statins

FEMS Microbiology Letters

Volumn 262, Issue 1, 2006, Pages 9-13

  Macreadie, Ian G ^a   Johnson, Georgia ^a   Schlosser, Tanja ^a   Macreadie, Peter I ^a  

^a CSIRO   (Australia)

Author keywords

Antifungal; Atorvastatin; Cholesterol; Ergosterol; HMG CoA reductase inhibition; Simvastatin

Indexed keywords

ATORVASTATIN; CHOLESTEROL; ERGOSTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; SIMVASTATIN;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA; CANDIDA ALBICANS; CANDIDA KRUSEI; CHOLESTEROL SYNTHESIS; DRUG MECHANISM; DRUG SPECIFICITY; FUNGAL COLONIZATION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA; CHOLESTEROL; ERGOSTEROL; GROWTH INHIBITORS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; PYRROLES; SIMVASTATIN;

ASPERGILLUS FUMIGATUS; CANDIDA; CANDIDA ALBICANS; ISSATCHENKIA ORIENTALIS;

EID: 33747077887     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2006.00370.x     Document Type: Article

References (10)

1. Baranova NA, Kreiner VG & Egorov NS (1996) The growth of Rhodotorula rubra yeasts and their synthesis of ergosterol on media with lovastatin. Antibiot Khimioter 41: 3-6.
2. Bibikova MV, Chmel' Ia V, Spiridonova IA & Katlinskii AV (2004) Lovastatin effect on ergosterol production and growth of Tolypocladium inflatum 106. Antibiot Khimioter 49: 3-6.
3. Chin NX, Weitzman I & Della-Latta P (1997) In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans. Antimicrob Agents Chemother 41: 850-852.
4. Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R & Bernini F (1999) New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther 84: 413-428.
5. Leber R, Landl K, Zinser E, Ahorn H, Spok A, Kohlwein SD, Turnowsky F & Daum G (1998) Dual localization of squalene epoxidase, Erg1p, in yeast reflects a relationship between the endoplasmic reticulum and lipid particles. Mol Biol Cell 9: 375-386.
6. Lorenz RT & Parks LW (1990) Effects of lovastatin (mevinolin) on sterol levels and on activity of azoles in Saccharomyces cerevisiae. Antimicrob Agents Chemother 34: 1660-1665.
7. Nash JD, Burgess DS & Talbert RL (2002) Effect of fluvastatin and pravastatin, HMG-CoA reductase inhibitors, on fluconazole activity against Candida albicans. J Med Microbiol 51: 105-109.
8. Orozco AS, Higginbotham LM, Hitchcock CA, Parkinson T, Falconer D, Ibrahim AS, Ghannoum MA & Filler SG (1998) Mechanism of fluconazole resistance in Candida krusei. Antimicrob Agents Chemother 42: 2645-2649.
9. Qiu MS, Pitts AF, Winters TR & Green SH (1991) ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. J Cell Biol 115: 795-808.
10. Roze LV & Linz JE (1998) Lovastatin triggers an apoptosis-like cell death process in the fungus Mucor racemosus. Fungal Genet Biol 25: 119-133.