How skeptical should we be about industry-sponsored studies?

Neurology

Volumn 67, Issue 3, 2006, Pages 378-379

  Chadwick, David ^a   Privitera, Michael ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; LAMOTRIGINE; PLACEBO; TOPIRAMATE;

CLINICAL TRIAL; COGNITIVE DEFECT; COMPARATIVE STUDY; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG MARKETING; DRUG RESEARCH; DRUG SAFETY; DRUG TOLERABILITY; EDITORIAL; EPILEPSY; HUMAN; METHODOLOGY; NEUROTOXICITY; PREDICTION; PRIORITY JOURNAL; QUALITY OF LIFE; RELIABILITY; RISK ASSESSMENT; SEIZURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

BIOMEDICAL RESEARCH; CONFLICT OF INTEREST; DRUG INDUSTRY; ETHICS, RESEARCH; HUMANS; RESEARCH SUPPORT;

EID: 33747076074     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000233974.67001.d0     Document Type: Editorial

References (7)

1. Blum D, Meador K, Biton V, et al. Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy. Neurology 2006;67:400-406.
2. Marson AG, Kadir ZA, Hutton JL, Chadwick DW. The new antiepileptic drugs: a systematic review of their efficacy and tolerability. Epilepsia 1997;38:859-880.
3. Tatum WO, French JA, Faught E, et al. Postmarketing experience with topiramate and cognition. Epilepsia 2001;42:1134-1140.
4. Aldenkamp AP, Baker G, Mulder OG, et al. A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in subjects with partial-onset seizures. Epilepsia 2000;41:1167-1178.
5. Meador KJ, Loring DW, Vahle VJ, et al. Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers. Neurology 2005;64:2108-2115.
6. Gamble C, Williamson PR, Chadwick DW, Marson AG. A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. Neurology 2006;66:1310-1317.
7. Dodson WE, Kamin M, Kraut L, Olson WH, Wu SC. Topiramate titration to response: analysis of individualized therapy study (TRAITS). Ann Pharmacother 2003;37:615-620.