Cloned transgenic heart-healthy pork?

Transgenic Research

Volumn 15, Issue 4, 2006, Pages 405-407

  Prather, Randall S ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Cloned swine; DNA methylation; fat 1 gene; Omega 3 fatty acids; Transgenic

Indexed keywords

OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL; CLONING; DNA METHYLATION; IMMUNE SYSTEM; MEAT; METABOLISM; PHENOTYPE; SHORT SURVEY; SWINE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CLONING, ORGANISM; DNA METHYLATION; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; IMMUNE SYSTEM; MEAT; PHENOTYPE; SWINE;

SUS SCROFA;

EID: 33747053942     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-006-0022-3     Document Type: Short Survey

References (14)

1. Bonk A, Samuel M, Lai L, Liu Z, Hao Y, Antoniou E, Prather RS (2005) Microarray based detection of differential cpg methylation in pig kidney and spleen tissues. Plant & Animal Genome meeting abstracts, p 701
2. Bonk AJ, Samuel M, Lai L, Hao YH, Li R, Liu ZH, Murphy C, Antoniou E, Prather RS (2006) DNA methylation in porcine gametes, in vitro, in vivo, parthenogenetic and nuclear transfer produced embryos. Reprod Fert Devel 18:109
3. Carter DB, Lai L, Park KW, Samuel M, Lattimer JC, Jordan KR, Estes DM, Besch-Williford C, Prather RS (2002) Phenotyping of transgenic cloned pigs. Clon Stem Cells 4:131-145
4. Dai YF, Vaught TD, Boone J, Chen SH, Phelps CJ, Ball S, Monahan JA, Jobst PM, McCreath KJ, Lamborn AE, Cowell-Lucero JL, Wells KD, Colman A, Polejaeva IA, Ayares DL (2002) Targeted disruption of the alpha 1,3-galactosyltransferase gene in cloned pigs. Nat Biotech 20:251-255
5. Duret L, Mouchiroud D (1999) Expression pattern and, surprisingly, gene length shape codon usage in caenorhabditis, drosophila, arabidopsis. Proc Natl Acad Sci USA 96:4482-4487
6. Huang THM, Perry MR, Laux DE (1999) Methylation profiling of cpg islands in human breast cancer cells. Hum Mol Genet 8:459-470
7. Kang JX, Wang JD, Wu L, Kang ZB (2004) Fat-1 mice convert n-6 to n-3 fatty acids. Nature 427:698
8. Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, Betthauser J, Carter DB, Greenstein JL, Hao Y, Im G-S, Liu Z, Mell GD, Murphy CN, Park K-W, Rieke A, Ryan D, Sachs DH, Forsberg EJ, Prather RS, Hawley RJ (2004) Alpha-1,3-galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 101:7335-7340
9. Lai L, Kang JX, Li R, Wang J, Witt W, Yong HY, Hao Y, Wax D, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans R, Starzl TE, Prather RS, Dai Y (2006) Generation of cloned transgenic transgenic pigs rich in omega-3 fatty acids. Nat Biotech 24:435-437
10. Lai LX, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, Samuel M, Bonk A, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ, Prather RS (2002) Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295:1089-1092
11. Li R, Lai L, Wax D, Hao Y, Murphy C, Rieke A, Samuel M, Linville M, Korte S, Evans RW, Turk JR, Kang JX, Witt WT, Dai Y, Prather RS (2006) Cloned transgenic swine via in vitro production and cryopreservation. Biol Reprod (in press)
12. Limon A, Briones J, Puig T, Carmona M, Fornas O, Cancelas JA, Nadal M, Garcia J, Rueda F, Barquinero J (1997) High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells. Blood 90:3316-3321
13. Prather RS (2006) Nuclear Remodeling and Nuclear Reprogramming for Making Transgenic Pigs by Nuclear Transfer. In: Somatic Cell Nuclear Transfer (Peter Sutovsky, ed.), Landes Bioscience, Georgetown, TX. pp 1-13
14. Spychalla JP, Kinney AJ, Browse J (1997) Identification of an animal omega-3 fatty acid desaturase by heterologous expression in arabidopsis. Proc Natl Acad Sci USA 94:1142-1147